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    Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain
    2.
    发明授权
    Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 有权
    用于脊髓刺激的完全可植入的微刺激作为慢性疼痛的治疗

    公开(公告)号：US06871099B1

    公开(公告)日：2005-03-22

    申请号：US09929597

    申请日：2001-08-13

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Carla M. Mann ,  Janusz A. Kuzma

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Carla M. Mann ,  Janusz A. Kuzma

    IPC分类号： A61N1/34 ,  A61N1/18

    CPC分类号： A61N1/36071

    摘要： An implantable stimulator(s), small enough to be located near or within an area of the spine responsible for sensations in a region experiencing chronic pain uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, it necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.

    摘要翻译： 小到足以位于脊柱区域内的负责在慢性疼痛区域感觉的植入式刺激器使用诸如可再充电电池的电源/存储装置。 这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。 必要时，必须使用外部设备将数据传送到和/或从激励器传输，并传输电力。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

    Microstimulator-based electrochemotherapy methods and systems
    3.
    发明授权
    Microstimulator-based electrochemotherapy methods and systems 失效
    基于微刺激剂的电化疗方法和系统

    公开(公告)号：US06733485B1

    公开(公告)日：2004-05-11

    申请号：US10133770

    申请日：2002-04-26

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Matthew I. Haller ,  Janusz A. Kuzma

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Matthew I. Haller ,  Janusz A. Kuzma

    IPC分类号： A61M3100

    CPC分类号： A61M31/002 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/205 ,  A61N1/326

    摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulation in the form of a direct electric current and/or a periodic waveform that locally potentiates the cytotoxic effects of a systemically and/or locally administered chemotherapy agent(s). Open- and closed-loop systems are disclosed.

    摘要翻译： 小型可植入刺激器包括至少两个用于将电刺激递送至周围组织和/或泵的电极以及用于将药物或药物递送至周围组织的至少一个出口。 所公开的一种电化疗方法包括以局部增强全身和/或局部施用的化疗剂的细胞毒性作用的直接电流和/或周期性波形的形式递送电刺激。 公开了开环和闭环系统。

    IMPLANTABLE ELECTRODES AND INSERTION METHODS AND TOOLS
    5.
    发明申请
    IMPLANTABLE ELECTRODES AND INSERTION METHODS AND TOOLS 失效
    可植入电极和插入方法和工具

    公开(公告)号：US20090149866A1

    公开(公告)日：2009-06-11

    申请号：US12371276

    申请日：2009-02-13

    申请人： Janusz A. Kuzma ,  Todd K. Whitehurst ,  Lani A. Smith ,  Chuladatta Thenuwara

    发明人： Janusz A. Kuzma ,  Todd K. Whitehurst ,  Lani A. Smith ,  Chuladatta Thenuwara

    IPC分类号： A61N1/05 ,  A61B17/00

    CPC分类号： A61N1/0551 ,  A61N1/0529 ,  A61N1/0553

    摘要： An insertion kit for implanting an electrode in a patient can include a handle; an insertion member coupled to the handle at a proximal end of the insertion member and configured and arranged to be inserted into a patient; an alignment member coupled to the handle and disposed over the distal end of the insertion member; and an electrode configured and arranged to be inserted into the patient using the insertion member. In some instances, the insertion kit may also include one or more of a marker that cooperates with the alignment member to mark a position of the electrode on the skin of the patient; a pointer that cooperates with the alignment member to find the marked position on the skin of the patient; and a second electrode and a second insertion member configured and arranged for detachably coupling to the handle in place of the insertion member.

    摘要翻译： 用于将电极植入患者体内的插入套件可以包括手柄; 插入构件，其在所述插入构件的近端处联接到所述手柄并且被配置和布置成插入到患者体内; 对准构件，其联接到所述手柄并设置在所述插入构件的远端上方; 以及电极，其构造和布置成使用插入构件插入到患者体内。 在一些情况下，插入套件还可以包括与对准构件配合以标记电极在患者皮肤上的位置的标记物中的一个或多个; 与对准构件协作以在患者皮肤上找到标记位置的指针; 以及第二电极和第二插入构件，其构造和布置成可替代所述插入构件可拆卸地联接到所述手柄。