公开(公告)号：US20170340732A1

公开(公告)日：2017-11-30

申请号：US15326569

申请日：2015-07-21

申请人： Japan as represented by Director General of National Institute of Infectious Diseases ,  Nippi, Incorporated

发明人： Shinji Saito ,  Tadaki Suzuki ,  Hideki Hasegawa ,  Akira Ainai ,  Kiyoko Goto ,  Tomonori Ueno ,  Yuki Taga

IPC分类号： A61K39/395 ,  C12N15/10 ,  C07K16/18 ,  C07K16/06 ,  C12N15/66 ,  C12N15/01 ,  A61K39/00

CPC分类号： A61K39/395 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/065 ,  C07K16/10 ,  C07K16/18 ,  C12N15/01 ,  C12N15/09 ,  C12N15/1086 ,  C12N15/66

摘要： Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.

公开(公告)号：US10925962B2

公开(公告)日：2021-02-23

申请号：US15326569

申请日：2015-07-21

申请人： Japan as represented by Director General of National Institute of Infectious Diseases ,  Nippi, Incorporated

发明人： Shinji Saito ,  Tadaki Suzuki ,  Hideki Hasegawa ,  Akira Ainai ,  Kiyoko Goto ,  Tomonori Ueno ,  Yuki Taga

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/09 ,  C07K16/06 ,  C12N15/01 ,  C12N15/10 ,  C12N15/66 ,  C07K16/10 ,  A61K39/00

摘要： Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.