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1.发明授权Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders 有权用于治疗炎症，心血管和CNS疾病的取代的苯扎唑PDE4抑制剂公开(公告)号：US08883833B2
公开(公告)日：2014-11-11
申请号：US12275165
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
IPC分类号： C07D513/04 , C07D498/04 , C07D417/04 , C07D417/06 , C07D417/14 , C07D277/64 , C07D277/82 , C07D263/56 , C07D263/58 , A61K31/519 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/428 , A61K31/423
CPC分类号： C07D417/14 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/06 , C07D498/04 , C07D513/04
摘要： The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is
摘要翻译： 本发明涉及用于治疗中风，心肌梗塞和心血管炎症状况的可用于治疗中风，心肌梗死和心血管炎症状况的苯环的吡啶和嘧啶环的取代苯并唑和其对应物与包含这些化合物的药物组合物的方法， 治疗哺乳动物的中风，心肌梗死和心血管炎症状况。 化合物具有通式I：其中A和B是碳环或杂环。 一个特定的实施例是
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2.发明申请BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS 审中-公开用于治疗肺动脉和心脏病的BIARYL PDE4抑制剂公开(公告)号：US20090136473A1
公开(公告)日：2009-05-28
申请号：US12275152
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
IPC分类号： A61K31/44 , C07D231/12 , C07D213/64 , C07D239/42 , C07D213/79 , C07C275/28 , C07D285/135 , A61K31/433 , A61K31/4439 , A61P1/00 , A61P11/00 , A61P35/00 , A61P9/00 , A61K31/122 , A61K31/4353 , A61K31/435 , A61K31/4427 , A61K31/437 , A61K31/4545 , C07D401/06 , C07D471/04 , C07D213/72 , A61K31/415 , A61K31/4412 , A61K31/495
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 化合物具有通式Ia，Ib，Ic或Id：具体实施方案是
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3.发明申请SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS 审中-公开替代苯扎唑PDE4抑制剂治疗肺动脉和心脏病公开(公告)号：US20090130076A1
公开(公告)日：2009-05-21
申请号：US12275164
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao
IPC分类号： A61K31/122 , C07D417/08 , A61K31/4965 , A61P35/00 , A61K31/4439 , C07D417/14
CPC分类号： C07D417/14 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/06 , C07D498/04 , C07D513/04
摘要： The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is
摘要翻译： 本发明涉及用于治疗中风，心肌梗塞和心血管炎症状况的可用于治疗中风，心肌梗死和心血管炎症状况的苯环的吡啶和嘧啶环的取代苯并唑和其对应物与包含这些化合物的药物组合物的方法， 治疗哺乳动物的中风，心肌梗死和心血管炎症状况。 化合物具有通式I：其中A和B是碳环或杂环。 一个特定的实施例是
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4.发明申请SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS 有权替代苯扎唑PDE4抑制剂治疗炎症，心血管疾病和中枢神经系统疾病公开(公告)号：US20090130077A1
公开(公告)日：2009-05-21
申请号：US12275165
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Munagala Rao
IPC分类号： A61K31/428 , C07D277/82 , C07D417/10 , C07D417/14 , C07D513/04 , C07D401/10 , A61K31/435 , A61K31/122 , A61P35/00 , A61P1/00 , A61P11/00 , A61K31/4353 , A61K31/496 , A61P9/00 , A61K31/454 , A61K31/4245 , A61K31/4439
CPC分类号： C07D417/14 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/06 , C07D498/04 , C07D513/04
摘要： The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is
摘要翻译： 本发明涉及用于治疗中风，心肌梗塞和心血管炎症状况的可用于治疗中风，心肌梗死和心血管炎症状况的苯环的吡啶和嘧啶环的取代苯并唑和其对应物与包含这些化合物的药物组合物的方法， 治疗哺乳动物的中风，心肌梗死和心血管炎症状况。 化合物具有通式I：其中A和B是碳环或杂环。 一个特定的实施例是
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5.发明申请BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS 审中-公开用于治疗炎症，心血管和中枢神经疾病的BIARYL PDE4抑制剂公开(公告)号：US20090324569A1
公开(公告)日：2009-12-31
申请号：US12275163
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
IPC分类号： A61K31/44 , C07D401/04 , C07D231/12 , C07D237/14 , C07D277/38 , C07D285/135 , C07D213/72 , C07D403/10 , C07D413/06 , C07D401/06 , A61K31/4427 , A61K31/5377 , A61K31/4439 , A61K31/4412 , A61K31/4164 , A61K31/4245 , A61K31/445 , A61K31/437 , A61K31/415 , A61K31/506 , A61K31/54 , A61K31/122 , A61K31/435 , A61P9/00 , A61P35/00 , A61P11/00
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 该化合物具有通式I：具体实施方案是
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6.发明授权Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders 有权用于治疗炎症，心血管和CNS疾病的二芳基PDE4抑制剂公开(公告)号：US08791267B2
公开(公告)日：2014-07-29
申请号：US13430164
申请日：2012-03-26
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
IPC分类号： C07D213/72 , A61K31/435
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 该化合物具有通式I：具体实施方案是
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公开(公告)号：US08877816B2
公开(公告)日：2014-11-04
申请号：US12275168
申请日：2008-11-20
IPC分类号： A61K31/165 , C07C233/02 , A61P29/00 , C07C311/08 , C07C275/32 , C07C43/295 , C07D213/73 , C07C45/71 , C07C43/29 , C07C205/38 , C07D213/81 , C07D213/83
CPC分类号： C07D213/73 , C07C43/29 , C07C43/295 , C07C45/71 , C07C205/38 , C07C275/32 , C07C311/08 , C07D213/81 , C07D213/83 , C07C47/575
摘要： Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
摘要翻译： 公开了下式的化合物。 该化合物作为磷酸二酯酶-4调节剂，可用于治疗中风，心肌梗死和心血管炎症状况。 还公开了其他实施例。
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8.发明申请BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS 有权用于治疗炎症，心脏病和中枢神经疾病的BIARYL PDE4抑制剂公开(公告)号：US20120183522A1
公开(公告)日：2012-07-19
申请号：US13430164
申请日：2012-03-26
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
IPC分类号： A61K31/4418 , C07D471/04 , A61K31/437 , C07D401/04 , A61K31/4427 , C07D237/14 , A61K31/50 , C07D413/12 , A61K31/501 , C07D413/06 , A61K31/5377 , C07D279/02 , A61K31/54 , A61K31/473 , A61K31/439 , A61K31/445 , A61K31/44 , A61K31/355 , A61K31/122 , A61K38/43 , A61P25/00 , A61P9/10 , A61P9/00 , A61P35/00 , A61P11/06 , A61P11/00 , A61P25/28 , A61P25/14 , A61P19/00 , A61P25/24 , A61P25/22 , A61P13/10 , C07D213/65
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 该化合物具有通式I：具体实施方案是
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公开(公告)号：US20090131530A1
公开(公告)日：2009-05-21
申请号：US12275168
申请日：2008-11-20
IPC分类号： A61K31/165 , C07C233/02 , A61P29/00
CPC分类号： C07D213/73 , C07C43/29 , C07C43/295 , C07C45/71 , C07C205/38 , C07C275/32 , C07C311/08 , C07D213/81 , C07D213/83 , C07C47/575
摘要： Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.
摘要翻译： 公开了下式的化合物。 该化合物作为磷酸二酯酶-4调节剂，可用于治疗中风，心肌梗死和心血管炎症状况。 还公开了其他实施例。
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公开(公告)号：US07985755B2
公开(公告)日：2011-07-26
申请号：US11832255
申请日：2007-08-01
申请人： Jasbir Singh , Mark E. Gurney
发明人： Jasbir Singh , Mark E. Gurney
IPC分类号： A61K31/517
CPC分类号： C07D239/95 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： 2,4-Diaminoquinazolines of formula (I) are provided herein and are useful for treating spinal muscular atrophy (SMA).
摘要翻译： 本文提供式（I）的2,4-二氨基喹唑啉，可用于治疗脊髓性肌萎缩（SMA）。
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