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公开(公告)号：US5891622A
公开(公告)日：1999-04-06
申请号：US28543
申请日：1998-02-24
CPC分类号： G01N33/88
摘要： A method to assess oxidative stress in vivo by measuring the amount of free, esterified and glucuronidated forms of isoprostanes (8EPGF2) in a biological sample which contains the isoprostanes is disclosed. The method further includes determining the amount of total isoprostanes present in the sample. This amount is compared with a control sample. The oxidative stress is determined through the comparison wherein the amount of isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control. Alternatively the method of the present invention provides for only the measurement of the glucuronidated form wherein the amount of glucuronidated isoprostanes increase in the sample isolated from an organism undergoing oxidative stress compared to the control.
摘要翻译： 公开了一种通过测量包含异前列烷烷的生物样品中游离，酯化和葡糖醛酸化形式的异前列烷（8EPGF2）的量来评估体内氧化应激的方法。 该方法还包括测定样品中存在的总异前列烷烷的量。 将该量与对照样品进行比较。 通过比较确定氧化应激，其中与对照相比，从经历氧化应激的生物体分离的样品中异前列烷的量增加。 或者，本发明的方法仅提供葡萄糖醛酸化形式的测量，其中与对照相比，从与经历氧化应激的生物体分离的样品中葡萄糖醛酸化的异前列烷的量增加。
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公开(公告)号：US20120328598A1
公开(公告)日：2012-12-27
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogues of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合物来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US4604357A
公开(公告)日：1986-08-05
申请号：US600141
申请日：1984-04-13
CPC分类号： C12N9/6462 , A61K35/22 , C12Y304/21073 , Y10S530/834
摘要： The invention relates to disinfectant urinal block means useful for collection of pooled urine and method of using the block means to provide in service release, of an antimicrobial agent component from the block means into the pool for effective inhibition of bacterial growth and consequent enzymatic degradation of wanted proteins contained in the pool.
摘要翻译： 本发明涉及用于收集汇集尿液的消毒小便池阻滞装置和使用阻滞装置将抗微生物剂组分从阻滞装置释放到池中以有效抑制细菌生长和随后的酶降解的方法 想要的蛋白质包含在池中。
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公开(公告)号：US20110117122A1
公开(公告)日：2011-05-19
申请号：US12947684
申请日：2010-11-16
IPC分类号： A61K36/06
CPC分类号： A61K36/02
摘要： The present invention discloses a composition and method for effecting various cytokines and NF-κB by administering an effective amount of a phyto-percolate composition to an individual. In various exemplary embodiments, the composition is claimed to be useful for the effective treatment of inflammation, cancer, and/or various infections including HIV by regulation of various interleukins, such as IL-10 and IL-2, and of transcription factors including NF-κB.
摘要翻译： 本发明公开了通过向个体施用有效量的植物渗透液组合物来实现各种细胞因子和NF-κB的组合物和方法。 在各种示例性实施方案中，所述组合物被认为可用于通过调节各种白介素（例如IL-10和IL-2）以及包括NF的转录因子有效治疗炎症，癌症和/或包括HIV的各种感染 - ＆kgr; B。
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公开(公告)号：US4557863A
公开(公告)日：1985-12-10
申请号：US600081
申请日：1984-04-13
CPC分类号： A61B10/007 , A61L28/0038 , Y10S435/815
摘要： The invention relates to a device useful when installed in a urinal for collection of urinary proteins. The adsorbent means includes a conduit for gravity feed passage of urine streams. The conduit has permeable layers in series containing a slow releasing antimicrobial agent and an adsorbent for urinary proteins such that for collection puropses wanted proteins are adsorbed without odor or loss due to bacterial degradation.
摘要翻译： 本发明涉及当安装在用于收集尿蛋白质的小便器中时有用的装置。 吸附装置包括用于尿流的重力进料通道的导管。 导管具有串联的渗透层，其包含缓释抗微生物剂和用于尿蛋白质的吸附剂，使得用于收集蛋白质需要蛋白质由于细菌降解而被吸附而没有气味或损失。
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公开(公告)号：US10161928B2
公开(公告)日：2018-12-25
申请号：US13812220
申请日：2011-07-21
摘要： A panel for monitoring levels of biomarkers, including an assay having at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test. A method of monitoring an individual's health, by collecting a sample from the individual, applying the sample to an assay panel, performing at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test in the panel, and determining levels of biomarkers related to inflammation, oxidative stress, and antioxidant activity and therefore providing information regarding the individual's relative health and/or risk of developing one or more diseases.
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公开(公告)号：US09486005B2
公开(公告)日：2016-11-08
申请号：US13580471
申请日：2011-02-22
申请人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
发明人： Smiti Vaid Gupta , Enrique Martinez, II , Fazlul H. Sarkar , Denis M. Callewaert , Andreea Geamanu , Kevin Michael Patrie , Tiffany Capri Thomas , Andrew A. Dahl
CPC分类号： A23L33/30 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0053 , A61K36/02 , A23V2200/3262 , A23V2250/202
摘要： A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of PAZ, specific components isolated from PAZ, chemically synthesized analogs of the components of PAZ, and regulating genes involved in lipoprotein metabolism. A method of treating high cholesterol levels in an individual by administering an effective amount of a microbial fermentation product, up-regulating the expression of at least one of the genes that encode ABCA1, ApoA1, and SRB1, and down-regulating the gene that encodes CETP. A method of preventing the onset of high cholesterol levels and/or a deleterious lipoprotein profile in an individual.
摘要翻译： 通过施用有效量的微生物发酵产物和调节涉及脂蛋白代谢的基因来治疗哺乳动物中的高胆固醇血症的方法。 通过施用有效量的选自PAZ，从PAZ分离的特异性成分，化学合成的PAZ组分的类似物和调节参与脂蛋白代谢的基因的组合来调节患者胆固醇水平的方法。 通过施用有效量的微生物发酵产物来治疗个体中高胆固醇水平的方法，上调编码ABCA1，ApoA1和SRB1的至少一个基因的表达，并下调编码的基因 CETP。 一种预防个体中高胆固醇水平和/或有害脂蛋白分布发生的方法。
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公开(公告)号：US20130122518A1
公开(公告)日：2013-05-16
申请号：US13812220
申请日：2011-07-21
CPC分类号： G01N33/50 , G01N33/53 , G01N33/6893 , G01N2800/7009 , G01N2800/7095 , Y10T436/173076
摘要： A panel for monitoring levels of biomarkers, including an assay having at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test. A method of monitoring an individual's health, by collecting a sample from the individual, applying the sample to an assay panel, performing at least one inflammation monitoring test, at least one oxidative stress monitoring test, and at least one antioxidant activity monitoring test in the panel, and determining levels of biomarkers related to inflammation, oxidative stress, and antioxidant activity and therefore providing information regarding the individual's relative health and/or risk of developing one or more diseases.
摘要翻译： 用于监测生物标志物水平的小组，包括具有至少一种炎症监测试验，至少一种氧化应激监测试验和至少一种抗氧化活性监测试验的试验。 通过从个体收集样品，将样品应用于测定面板，进行至少一种炎症监测测试，至少一种氧化应激监测测试和至少一种抗氧化活性监测测试来监测个体健康的方法 并确定与炎症，氧化应激和抗氧化活性相关的生物标志物的水平，因此提供关于个体的相对健康和/或发展一种或多种疾病的风险的信息。
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