公开(公告)号：US09945872B2

公开(公告)日：2018-04-17

申请号：US13541462

申请日：2012-07-03

申请人： Jason Flora ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Edwin J. C. G. van den Oord ,  Bradley Todd Webb ,  Timothy York ,  Gaurav S. J. B. Rana ,  Jeffrey S. Edmiston ,  Willie J. McKinney

发明人： Jason Flora ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Edwin J. C. G. van den Oord ,  Bradley Todd Webb ,  Timothy York ,  Gaurav S. J. B. Rana ,  Jeffrey S. Edmiston ,  Willie J. McKinney

IPC分类号： G01N33/68 ,  C40B40/10 ,  C07K17/00 ,  C07H21/00 ,  C40B40/08 ,  C40B20/02 ,  G01N33/574

CPC分类号： G01N33/6893 ,  C07H21/00 ,  C07K17/00 ,  C40B20/02 ,  C40B40/08 ,  C40B40/10 ,  G01N33/57423 ,  G01N33/6848 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/60

摘要： Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions.

公开(公告)号：US20130149389A1

公开(公告)日：2013-06-13

申请号：US13541462

申请日：2012-07-03

申请人： Jason FLORA ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Edwin J.C.G. van den Oord ,  Bradley Todd Webb ,  Timothy York ,  Gaurav S. J. B. Rana ,  Jeffrey S. Edmiston ,  Willie J. McKinney

发明人： Jason FLORA ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Edwin J.C.G. van den Oord ,  Bradley Todd Webb ,  Timothy York ,  Gaurav S. J. B. Rana ,  Jeffrey S. Edmiston ,  Willie J. McKinney

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  C07H21/00 ,  C07K17/00 ,  C40B20/02 ,  C40B40/08 ,  C40B40/10 ,  G01N33/57423 ,  G01N33/6848 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/60

摘要： Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions.

摘要翻译： 吸烟是慢性阻塞性肺疾病（COPD）的主要决定因素，这是美国发病率和死亡率的第四大原因。 已经使用综合的高通量蛋白质组学方法鉴定了能够区分可能经历快速（RPD）或慢（SLW）肺功能的受试者的COPD相关的独特蛋白质。 定向为21种独特蛋白质的三十种肽与COPD吸烟者的年龄化肺功能衰退率呈线性相关，COPD特征为快速或缓慢下降，吸烟者无COPD。 使用三种不同的统计方法来评估数据，RPD和SLW组被55个肽区分，其映射到33个独特的蛋白质。 许多鉴定的肽是参与补体和/或凝血系统的蛋白质的蛋白水解片段，具有抗蛋白酶活性或代谢功能。