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公开(公告)号：US06685944B1
公开(公告)日：2004-02-03
申请号：US09763260
申请日：2001-10-19
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： The present invention provides 1) an isolated peptide having the amino acid sequence DLMGYIPAV, (SEQ ID NO: 1); 2) an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139; 3) an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2; and 4) a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence SEQ ID NO: 1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. The present invention further provides methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
摘要翻译： 本发明提供1）具有氨基酸序列DLMGYIPAV（SEQ ID NO：1）的分离肽; 2）在氨基酸位置139包含L> A取代的分离的HCV核心多肽; 3）具有SEQ ID NO：2的氨基酸序列的分离的HCV核心多肽; 和4）具有比整个HCV核心多肽更少的氨基酸并且包含氨基酸序列SEQ ID NO：1的HCV核心多肽的片段。还提供编码本发明的肽和多肽的核酸，其包含 本发明的核酸和包含本发明的载体和核酸的细胞。 本发明进一步提供了在受试者中产生免疫应答和/或治疗或预防受试者的HCV感染的方法，其包括对受试者或受试者的细胞施用任何本发明的组合物。
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公开(公告)号：US07074410B2
公开(公告)日：2006-07-11
申请号：US10770117
申请日：2004-02-02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO:1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
摘要翻译： 提供了具有氨基酸序列DLMGYIPAV（SEQ ID NO：1）的分离的肽，在氨基酸位置139包含L> A取代的分离的HCV核心多肽，具有SEQ ID NO：1的氨基酸序列的分离的HCV核心多肽 NO：2和HCV核心多肽的片段，其具有比整个HCV核心多肽更少的氨基酸并且包含SEQ ID NO：1的氨基酸序列。 还提供了编码本发明的肽和多肽的核酸，包含本发明的核酸的载体和包含本发明的载体和核酸的细胞。 还提供了在受试者中产生免疫应答和/或治疗或预防受试者的HCV感染的方法，包括向受试者或受试者的细胞施用本发明的任何组合物。
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公开(公告)号：US07341726B2
公开(公告)日：2008-03-11
申请号：US11429670
申请日：2006-05-05
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO:1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
摘要翻译： 提供了具有氨基酸序列DLMGYIPAV（SEQ ID NO：1）的分离的肽，在氨基酸位置139包含L> A取代的分离的HCV核心多肽，具有SEQ ID NO：1的氨基酸序列的分离的HCV核心多肽 NO：2和HCV核心多肽的片段，其具有比整个HCV核心多肽更少的氨基酸并且包含SEQ ID NO：1的氨基酸序列。 还提供了编码本发明的肽和多肽的核酸，包含本发明的核酸的载体和包含本发明的载体和核酸的细胞。 还提供了在受试者中产生免疫应答和/或治疗或预防受试者的HCV感染的方法，包括向受试者或受试者的细胞施用本发明的任何组合物。
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公开(公告)号：US20060275322A1
公开(公告)日：2006-12-07
申请号：US11429670
申请日：2006-05-05
申请人： Jay Berzofsky , Pablo Sarobe , Stephen Feinstone , Marian Major
发明人： Jay Berzofsky , Pablo Sarobe , Stephen Feinstone , Marian Major
IPC分类号： A61K39/12 , A61K39/395
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO: 1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
摘要翻译： 提供了具有氨基酸序列DLMGYIPAV（SEQ ID NO：1）的分离的肽，在氨基酸位置139包含L> A取代的分离的HCV核心多肽，具有SEQ ID NO：1的氨基酸序列的分离的HCV核心多肽 NO：2，以及HCV核心多肽的片段，其具有比整个HCV核心多肽更少的氨基酸并且包含SEQ ID NO：1的氨基酸序列。还提供了编码本发明的肽和多肽的核酸， 包含本发明核酸的载体和包含本发明的载体和核酸的细胞。 还提供了在受试者中产生免疫应答和/或治疗或预防受试者的HCV感染的方法，包括向受试者或受试者的细胞施用本发明的任何组合物。
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公开(公告)号：US20050129705A1
公开(公告)日：2005-06-16
申请号：US10770117
申请日：2004-02-02
申请人： Jay Berzofsky , Stephen Feinstone , Marian Major , Pablo Sarobe
发明人： Jay Berzofsky , Stephen Feinstone , Marian Major , Pablo Sarobe
IPC分类号： A61K39/00 , A61K39/29 , C07H21/04 , C07K14/02 , C07K14/18 , C12N15/40 , C12N15/86 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/55522 , A61K2039/55538 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence of SEQ ID NO:1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. Further provided are methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.
摘要翻译： 提供了具有氨基酸序列DLMGYIPAV（SEQ ID NO：1）的分离的肽，在氨基酸位置139包含L> A取代的分离的HCV核心多肽，具有SEQ ID NO：1的氨基酸序列的分离的HCV核心多肽 NO：2和HCV核心多肽的片段，其具有比整个HCV核心多肽更少的氨基酸并且包含SEQ ID NO：1的氨基酸序列。 还提供了编码本发明的肽和多肽的核酸，包含本发明的核酸的载体和包含本发明的载体和核酸的细胞。 还提供了在受试者中产生免疫应答和/或治疗或预防受试者的HCV感染的方法，包括向受试者或受试者的细胞施用本发明的任何组合物。
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