公开(公告)号：US20100317018A1

公开(公告)日：2010-12-16

申请号：US12855178

申请日：2010-08-12

申请人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

公开(公告)号：US20110306518A1

公开(公告)日：2011-12-15

申请号：US13215139

申请日：2011-08-22

申请人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C40B30/04 ,  C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

摘要翻译： 描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。 还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

公开(公告)号：US07892745B2

公开(公告)日：2011-02-22

申请号：US12584615

申请日：2009-09-08

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

公开(公告)号：US20060088836A1

公开(公告)日：2006-04-27

申请号：US10511937

申请日：2003-04-24

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q1/6881 ,  C12Q1/6888 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6863 ,  G01N2800/245

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

摘要翻译： 描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。 还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

公开(公告)号：US20110104697A1

公开(公告)日：2011-05-05

申请号：US12985314

申请日：2011-01-05

申请人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay WOHLGEMUTH ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

公开(公告)号：US20100151467A1

公开(公告)日：2010-06-17

申请号：US12584615

申请日：2009-09-08

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

公开(公告)号：US20100099098A1

公开(公告)日：2010-04-22

申请号：US12544182

申请日：2009-08-19

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6881 ,  C12Q1/6888 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6863 ,  G01N2800/245

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

摘要翻译： 描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。 还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

公开(公告)号：US07691569B2

公开(公告)日：2010-04-06

申请号：US10511937

申请日：2003-04-24

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6881 ,  C12Q1/6888 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6863 ,  G01N2800/245

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

摘要翻译： 描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。 还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

公开(公告)号：US07879556B2

公开(公告)日：2011-02-01

申请号：US12855178

申请日：2010-08-12

申请人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  MacDonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/564 ,  Y10T436/143333

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

摘要翻译： 描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。 还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

公开(公告)号：US20060204991A1

公开(公告)日：2006-09-14

申请号：US11360146

申请日：2006-02-22

申请人： Robert Lipshutz ,  MacDonald Morris ,  Mark Chee ,  Thomas Gingeras

发明人： Robert Lipshutz ,  MacDonald Morris ,  Mark Chee ,  Thomas Gingeras

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6806 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6837 ,  C40B40/06 ,  C12Q2565/107 ,  C12Q2525/155

摘要： This invention provides nucleic acid affinity matrices that bear a large number of different nucleic acid affinity ligands allowing the simultaneous selection and removal of a large number of preselected nucleic acids from the sample Methods of producing such affinity matrices are also provided In general the methods involve the steps of a) providing a nucleic acid amplification template array comprising a surface to which are attached at least 50 oligonucleotides having different nucleic acid sequences, and wherein each different oligonucleotide is localized in a predetermined region of said surface, the density of said oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and all of said different oligonucleotides have an identical terminal 3′ nucleic acid sequence and an identical terminal 5′ nucleic acid sequence b) amplifying said multiplicity of oligonucleotides to provide a pool of amplified nucleic acids, and c) attaching the pool of nucleic acids to a solid support

摘要翻译： 本发明提供了携带大量不同核酸亲和配体的核酸亲和基质，允许从样品中同时选择和除去大量预选择的核酸。还提供了产生这种亲和基质的方法一般来说，该方法涉及 步骤a）提供核酸扩增模板阵列，其包含与至少50个具有不同核酸序列的寡核苷酸连接的表面，并且其中每个不同的寡核苷酸定位在所述表面的预定区域中，所述寡核苷酸的密度较大 每1cm 2超过约60个不同的寡核苷酸，并且所有所述不同的寡核苷酸具有相同的末端3'核酸序列和相同的末端5'核酸序列b）扩增所述多重寡核苷酸以提供 一组扩增的核酸，以及c）附着核酸池 酸固体支持物