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公开(公告)号:US08440710B2
公开(公告)日:2013-05-14
申请号:US12900621
申请日:2010-10-08
申请人: Jean Ackermann , Stephan Brugger , Aurelia Conte , Daniel Hunziker , Werner Neidhart , Matthias Nettekoven , Tanja Schulz-Gasch , Stanley Wertheimer
发明人: Jean Ackermann , Stephan Brugger , Aurelia Conte , Daniel Hunziker , Werner Neidhart , Matthias Nettekoven , Tanja Schulz-Gasch , Stanley Wertheimer
IPC分类号: A61K31/4015 , C07D209/96
CPC分类号: C07D209/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof. The are useful as HSL inhibitors and may, for example, be used in treatment of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis, and obesity.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐。 它们可用作HSL抑制剂,并且可以例如用于治疗糖尿病,代谢综合征,血脂异常,动脉粥样硬化和肥胖症。
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公开(公告)号:US20110092512A1
公开(公告)日:2011-04-21
申请号:US12900621
申请日:2010-10-08
申请人: Jean Ackermann , Stephan Brugger , Aurelia Conte , Daniel Hunziker , Werner Neidhart , Matthias Nettekoven , Tanja Schulz-Gasch , Stanley Wertheimer
发明人: Jean Ackermann , Stephan Brugger , Aurelia Conte , Daniel Hunziker , Werner Neidhart , Matthias Nettekoven , Tanja Schulz-Gasch , Stanley Wertheimer
IPC分类号: A61K31/501 , C07D209/54 , A61K31/403 , C07D403/12 , A61K31/506 , A61K31/497 , C07D401/04 , A61K31/4439 , C07D417/08 , C07D403/08 , A61K31/4192 , A61K31/4155 , C07D413/08 , A61K31/422 , A61P3/10 , A61P3/04 , A61P3/06 , A61P1/16 , A61P9/00 , A61P9/10 , A61P29/00
CPC分类号: C07D209/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof. The are useful as HSL inhibitors and may, for example, be used in treatment of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis, and obesity.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐。 它们可用作HSL抑制剂,并且可以例如用于治疗糖尿病,代谢综合征,血脂异常,动脉粥样硬化和肥胖症。
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公开(公告)号:US5309900A
公开(公告)日:1994-05-10
申请号:US774080
申请日:1991-10-09
申请人: Martin Knoch , Stephan Brugger
发明人: Martin Knoch , Stephan Brugger
CPC分类号: A61M15/0086 , A61M11/06 , A61M2206/16
摘要: Inhalation therapy is not only used for the treatment of respiratory tract diseases, but also increasingly for administering other medicinal substances. In this kind of therapy, the substance is made available to the patient for inhalation in the form of a liquid vapor having very small droplet diameters (ca. 1 to 5 um) and is transported together with the inhaled air into the respiratory tracts. The inventive atomizer consists of a cylindrical atomizing space with two openings for respectively supplying and withdrawing the liquid vapor, the openings being arranged in such a manner that a spiral vortex is formed which extends about the longitidunal axis of the atomizing space.
摘要翻译: 吸入治疗不仅用于治疗呼吸道疾病,而且也越来越多地用于治疗其他药物。 在这种治疗中,该物质可以以具有非常小的液滴直径(约1至5um)的液体蒸汽的形式吸入患者,并与吸入的空气一起运送到呼吸道中。 本发明的雾化器由具有用于分别供应和取出液体蒸气的两个开口的圆柱形雾化空间组成,所述开口以这样一种方式布置,即形成围绕雾化空间的长孔轴线延伸的螺旋涡流。
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公开(公告)号:US06514177B1
公开(公告)日:2003-02-04
申请号:US08741768
申请日:1996-11-05
申请人: Stephan Brugger , Erich Hertl , Andreas Lintl , Matthias Remke
发明人: Stephan Brugger , Erich Hertl , Andreas Lintl , Matthias Remke
IPC分类号: A63B2318
CPC分类号: F04B43/0054 , A61M11/06 , F04B45/04
摘要: A diaphragm assembly for the diaphragm pump of an inhaling apparatus compressor contains a flexible diaphragm 1,21 with a first opening 2, 22, a lower diaphragm disc 6, 26, with a second opening 8, 28, and an upper diaphragm disc 14, 38 with a third opening 16, 40, said diaphragm discs 6, 14, 26, 38 having a smaller diameter than the flexible diaphragm 1, 21, and a securement member 18, 44, for clamping the diaphragms 1, 21, between the lower diaphragm discs 6, 26 and the upper diaphragm discs 14, 38, said securement member 18, 44 being guided through the first, second and third opening 2, 12, 16, 22, 28, 40 and being in engagement with a diaphragm drive device. For the improvement of the operational behavior and production ability, it is proposed that on the outer periphery of the flexible diaphragms 1, 21, a strip-shaped portion 4, 24 be bent towards the axis of the securement member 18, 44 and along the upper rim of the second opening 8, 28 a stop member 10, 30, be formed, against which the inside rim of the first opening of the flexible diaphragm 1, 21 can abut.
摘要翻译: 用于吸入装置压缩机的隔膜泵的隔膜组件包括具有第一开口2,22的柔性隔膜1,21,具有第二开口8,28和下隔膜盘14的下隔膜盘6,26, 38具有第三开口16,40,所述隔膜盘6,14,26,38具有比柔性隔膜1,21更小的直径,以及固定构件18,44,用于将隔膜1,21夹紧在下部 隔膜盘6,26和上隔膜盘14,38,所述固定构件18,44被引导穿过第一,第二和第三开口2,16,16,22,28,40并与隔膜驱动装置 为了提高操作性能和生产能力,提出在柔性隔膜1,21的外周上,条状部分4,24朝着固定件18,44的轴线弯曲并沿着 第二开口8,28的上边缘与止动件10,30形成 柔性隔膜1,21的第一开口的内缘可以邻接。
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公开(公告)号:US06513727B1
公开(公告)日:2003-02-04
申请号:US09333429
申请日:1999-06-15
申请人: Stefan Jaser , Matthias Remke , Stephan Brugger
发明人: Stefan Jaser , Matthias Remke , Stephan Brugger
IPC分类号: B67D508
CPC分类号: B05B7/0012 , A61L2/26 , A61L2202/11 , A61M11/002 , A61M11/06 , B05B15/00
摘要: The present invention relates to a liquid atomizer device for producing aerosols. The device includes a first housing part (A) which includes an inner member (3) of an atomizer nozzle and a first connection for connecting the first housing part (A) to a further housing part to form a nebulizing chamber (1), and further includes a second housing part (B) that includes an outer member of the atomizer nozzle which can be brought into engagement with the inner member (3) to form the atomizer nozzle, and a second connection means (11) that can be brought into engagement with the first connection (9) for connecting the second housing part to the first housing part. The invention is characterized in that a service life indicator (L) is arranged at a place that does not impede the flow passing through the device, but is accessible to the aerosol and a sterilant.
摘要翻译: 本发明涉及一种用于生产气溶胶的液体雾化装置。 该装置包括:第一壳体部分(A),其包括雾化喷嘴的内部构件(3)和用于将第一壳体部分(A)连接到另一个壳体部分以形成雾化室(1)的第一连接件;以及 还包括第二壳体部分(B),其包括可以与内部构件(3)接合以形成雾化喷嘴的雾化喷嘴的外部构件,以及可以被引入到第二连接装置 与用于将第二壳体部件连接到第一壳体部分的第一连接件(9)接合。 本发明的特征在于,使用寿命指示器(L)被布置在不妨碍流过该装置的流动但可被气溶胶和消毒剂接近的位置。
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公开(公告)号:US4949715A
公开(公告)日:1990-08-21
申请号:US231812
申请日:1988-08-12
申请人: Stephan Brugger
发明人: Stephan Brugger
CPC分类号: A61M15/00
摘要: The invention relates to a transportable inhalation device, which can be driven with an accumulator (25), independently of the electric network. In an aerosol mister (7) that is separated from the rest of the device, a medication solution is atomized by means of compressed-air, introduced to an aerosol. The compressed-air that is required for this is generated by a compressed-air generator 23. A hand-actuated valve (14), mounted on the aerosol mister (7), blocks the supply of compressed-air. The compressed air generator (23) is driven by an electric motor (24). The electric motor (23) is controlled by means of an electronic controller (31), to which a pressure sensor (30), which is arranged between the compressed-air generator (23) and the valve (14) is attached electrically. In response to this pressure sensor (30), the controller (31) automatically switches on the electric motor (24), as soon as a pre-determined minimum pressure is exceeded within the compressed-air hose (11). Thus the compressed-air generator (23) is always driven only when by actuating the valve (14) the patient lets the compressed-air flow into the aerosol mister (7). The automatically, pressure-controlled operating method completely utilizes the electric energy stored in the accumulator (25), and permits the inhalation device of the invention to be operated in an especially efficient manner.
摘要翻译: 本发明涉及一种可运输的吸入装置,其可以与蓄电池(25)一起驱动,独立于电网。 在与装置的其余部分分离的气雾剂(7)中,通过压缩空气将药物溶液雾化,引入气溶胶。 所需的压缩空气由压缩空气发生器23产生。安装在气溶胶喷雾器(7)上的手动阀(14)阻挡压缩空气的供应。 压缩空气发生器(23)由电动机(24)驱动。 电动机(23)由电子控制器(31)控制,设置在压缩空气发生器(23)和阀(14)之间的压力传感器(30)电连接到该控制器上。 响应于该压力传感器(30),一旦压缩空气软管(11)中超过预定的最小压力,控制器(31)就会自动接通电动机(24)。 因此,只有当致动阀(14)时,压缩空气发生器(23)总是被驱动,患者使压缩空气流入气溶胶灭菌器(7)。 自动压力控制的操作方法完全利用蓄能器(25)中存储的电能,并且以特别有效的方式允许本发明的吸入装置的操作。
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公开(公告)号:US4674491A
公开(公告)日:1987-06-23
申请号:US764043
申请日:1985-08-09
申请人: Inge Brugger , Stephan Brugger
发明人: Inge Brugger , Stephan Brugger
CPC分类号: A61M11/06 , A61M11/002 , A61M2209/08
摘要: The invention relates to an inhaler for atomization, dispersing and mixing of fluid or powdery substances by means of a pressurized gas flow (30) for production of an aerosol. The inhaler consists of an atomization head (1) arranged in the upper end of a two part hand grip (2). The atomization head (1) has a central atomization nozzle comprised of a nozzle head (23) and a gas flow controller (27), a connection passage (21) for pressurized gas supply, an air supply chimney (28) and an aerosol outlet passage (28) for connection to a mouthpiece. The nozzle head (23) contains a central pressurized gas passage (22) and lateral suction channels (24,25) for the atomization material (26). According to the invention the atomization head (1) has a spherical shape and is surrounded by correspondingly shaped hollow spherical parts (5,6) of the hand grip. The low height is achieved in that between the container (18) receiving the atomization material (26) and the cap (19), an insert (20) and a deflector (31) on the lower edge of the air supply chimney (28) are provided, by which the aerosol flow produced is guided in a labyrinthine manner via an edge (32) on the deflector (31) and an edge (33) on an insert (20) to the outlet passage (29). In this way, larger particles unsuitable for lung ingestion (extra thoracic) are excluded.
摘要翻译: 本发明涉及一种用于通过用于产生气溶胶的加压气流(30)来雾化,分散和混合流体或粉末状物质的吸入器。 吸入器由布置在两部分手柄(2)的上端的雾化头(1)组成。 雾化头(1)具有由喷嘴头(23)和气流控制器(27)组成的中心雾化喷嘴,用于加压气体供应的连接通道(21),空气供应烟囱(28)和气溶胶出口 通道(28),用于连接到喉舌。 喷嘴头(23)包含中心加压气体通道(22)和用于雾化材料(26)的侧向抽吸通道(24,25)。 根据本发明,雾化头(1)具有球形并被手柄的相应形状的中空球形部分(5,6)包围。 在空气供应烟囱(28)的下边缘处的接收雾化材料(26)的容器(18)和盖(19),容器(18)和插入件(20)和偏转器(31)之间达到较低的高度, 通过其产生的气溶胶流以迷宫方式通过偏转器(31)上的边缘(32)和插入件(20)上的边缘(33)被引导到出口通道(29)。 以这种方式,排除不适合肺部摄取(胸外)的较大颗粒。
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