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    Structurally modified peptides that are resistant to peptidase degradation
    2.
    发明授权
    Structurally modified peptides that are resistant to peptidase degradation 失效
    对肽酶降解有抗性的结构修饰的肽

    公开(公告)号：US06623740B1

    公开(公告)日：2003-09-23

    申请号：US09114002

    申请日：1998-07-10

    申请人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    发明人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    IPC分类号： A61K3800

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  Y10S514/885

    摘要： Human melanoma cells bear antigens that are recognized by autologous CD8+ cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically.

    摘要翻译： 人黑素瘤细胞承载由自体CD8 +细胞毒性T淋巴细胞识别的抗原。 本发明涉及通过HLA分子接收MZ2-E抗原的特定肽类似物。 本文公开了经修饰以抵抗肽酶降解的肿瘤抗原MZ2-E的肽类似物，并且其结合HLA分子以形成其特异性溶细胞T细胞的识别导致复合物裂解的复合物。 肽类似物/ HLA复合物的溶细胞T细胞的鉴定可用于诊断或治疗。

    Novel Phosphorylated Sequences of the Phosphatase Cdc25B, Antibodies for Said Sequences and Use Thereof
    4.
    发明申请
    Novel Phosphorylated Sequences of the Phosphatase Cdc25B, Antibodies for Said Sequences and Use Thereof 审中-公开
    磷酸酶Cdc25B的新型磷酸化序列，所述序列的抗体及其用途

    公开(公告)号：US20080008712A1

    公开(公告)日：2008-01-10

    申请号：US10560237

    申请日：2004-06-08

    申请人： Bernard Ducommun ,  Bernard Monsarrat ,  Claude Prigent

    发明人： Bernard Ducommun ,  Bernard Monsarrat ,  Claude Prigent

    IPC分类号： A61K39/395 ,  A61K38/10 ,  A61P35/00 ,  C07K16/44 ,  C12P21/08 ,  G01N33/566 ,  C07K7/08 ,  C07K14/00 ,  A61K38/16

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The present invention relates to a peptide sequence characterized in that it comprises or is constituted by a fragment of at least approximately 10 amino acids originating from the following sequence SEQ ID NO: 1: TPVQNKRRRSpVTPPEEQQESEQ ID NO: 1 in which the serine residue in position 10 is phosphorylated, said above-mentioned fragment containing said phosphorylated serine residue. The present invention also relates to a polyclonal or monoclonal antibody capable of recognizing a peptide sequence as defined above.

    摘要翻译： 本发明涉及一种肽序列，其特征在于其包含或由至少约10个氨基酸的片段构成，源自以下序列SEQ ID NO：1：

    TPVQNKRRRS < / SUB> VTPPEEQQE SEQ ID NO：1 位置10被磷酸化，所述上述含有所述磷酸化丝氨酸残基的片段。 本发明还涉及能够识别上述肽序列的多克隆或单克隆抗体。