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公开(公告)号:US08013128B2
公开(公告)日:2011-09-06
申请号:US12397992
申请日:2009-03-04
申请人: Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号: A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US08278424B2
公开(公告)日:2012-10-02
申请号:US13094730
申请日:2011-04-26
申请人: Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: C07K16/00 , C12P21/08 , C07K16/30 , G01N33/53 , G01N33/567 , G01N33/574 , C07H21/02 , C07H21/04
CPC分类号: C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US20110262968A1
公开(公告)日:2011-10-27
申请号:US13094730
申请日:2011-04-26
申请人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
CPC分类号: C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US07595379B2
公开(公告)日:2009-09-29
申请号:US11131648
申请日:2005-05-17
申请人: Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
CPC分类号: A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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5.
公开(公告)号:US20130041138A1
公开(公告)日:2013-02-14
申请号:US13631699
申请日:2012-09-28
申请人: Jean GUDAS , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: C07K16/30
CPC分类号: C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US20090181034A1
公开(公告)日:2009-07-16
申请号:US12397992
申请日:2009-03-04
申请人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jene Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人: Jean GUDAS , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jene Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号: A61K39/395 , C12Q1/68 , A61P35/00
CPC分类号: A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
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公开(公告)号:US20050221400A1
公开(公告)日:2005-10-06
申请号:US11131648
申请日:2005-05-17
申请人: Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Karen Morrison , Hui Shao , Pia Challita-Eid , Arthur Raitano
发明人: Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Karen Morrison , Hui Shao , Pia Challita-Eid , Arthur Raitano
IPC分类号: C07K20060101 , C07K14/47 , C07K14/705 , C07K16/30 , C07K16/46 , C12N20060101 , G01N33/574
CPC分类号: A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译: 其中PSCA在正常成人组织中表现出组织特异性表达,并且在表I中列出的癌症中异常表达。因此,PSCA提供诊断,预后, 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号:US10009318B2
公开(公告)日:2018-06-26
申请号:US13419434
申请日:2012-03-14
申请人: Hui Shao
发明人: Hui Shao
CPC分类号: H04L63/0272 , H04L63/04 , H04L63/08
摘要: A client may connect to a server over an insecure network by downloading and configuring a secure connection mechanism to the server. The secure connection mechanism may allow the client to join a domain when connected to the server and access domain level services. The server may receive a request from the client, classify the connection type, and used the classification to determine whether the request originated off premises. If so, the server may send a configuration mechanism to the client, which may then establish a secure connection to the server. Once the secure connection is established, the server may join the client to the server's domain and begin secure operations.
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公开(公告)号:US08245323B2
公开(公告)日:2012-08-21
申请号:US12343113
申请日:2008-12-23
申请人: Hui Shao
发明人: Hui Shao
IPC分类号: A45D44/12
CPC分类号: A45D44/12
摘要: A head-worn liquid shield has a substantially half-circled brim, a tautening edge portion, and a sealing tube that provides an effective sealing means for protecting a user's face, nose, ears and eyes from water, soap, shampoo and other hairdressing materials. The sealing tube is compressible to result in a diameter size automatically adjusted according to the pressure exerted on the sealing tube by the user's head.
摘要翻译: 头戴式液体护罩具有大致半圆形的边缘,整形边缘部分和密封管,其提供有效的密封装置,用于保护使用者的脸部,鼻子,耳朵和眼睛免受水,肥皂,洗发剂和其他美发材料的影响 。 密封管是可压缩的,导致根据用户头部施加在密封管上的压力自动调整的直径尺寸。
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公开(公告)号:US20100154100A1
公开(公告)日:2010-06-24
申请号:US12343113
申请日:2008-12-23
申请人: Hui Shao
发明人: Hui Shao
IPC分类号: A45D44/12
CPC分类号: A45D44/12
摘要: A head-worn liquid shield has a substantially half-circled brim, a tautening edge portion, and a sealing tube that provides an effective sealing means for protecting a user's face, nose, ears and eyes from water, soap, shampoo and other hairdressing materials. The sealing tube is compressible to result in a diameter size automatically adjusted according to the pressure exerted on the sealing tube by the user's head.
摘要翻译: 头戴式液体护罩具有大致半圆形的边缘,整形边缘部分和密封管,其提供有效的密封装置,用于保护使用者的脸部,鼻子,耳朵和眼睛免受水,肥皂,洗发剂和其他美发材料的影响 。 密封管是可压缩的,导致根据用户头部施加在密封管上的压力自动调节的直径尺寸。
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