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公开(公告)号：US09644039B2
公开(公告)日：2017-05-09
申请号：US12987679
申请日：2011-01-10
IPC分类号： A61F2/00 , C08B37/00 , A61K9/16 , A61L17/10 , A61L17/14 , A61L27/14 , A61L27/34 , A61L27/58 , A61L31/10 , A61L31/14 , C08B30/18 , C08B37/02 , C08L1/02 , C08L1/08 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/06
CPC分类号： C08B37/0006 , A61K9/00 , A61K9/1652 , A61K38/02 , A61K38/16 , A61K39/00 , A61K39/0011 , A61K39/385 , A61K39/395 , A61K45/06 , A61K47/48 , A61K47/6939 , A61K2039/55555 , A61K2039/55561 , A61L17/10 , A61L17/145 , A61L27/14 , A61L27/34 , A61L27/58 , A61L31/10 , A61L31/148 , B82Y5/00 , C08B30/18 , C08B37/0021 , C08B37/14 , C08F8/00 , C08F8/28 , C08F16/06 , C08L1/02 , C08L1/08 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/06 , C08L101/02 , C09D129/14
摘要： Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.
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公开(公告)号：US20110229550A1
公开(公告)日：2011-09-22
申请号：US12987679
申请日：2011-01-10
IPC分类号： A61K9/00 , C08B37/02 , C08B37/14 , C08B30/18 , A61K31/7088 , A61K38/02 , A61K38/16 , A61K39/395 , A61K39/00 , A61P37/04 , A61P25/00 , A61P35/00 , A61P31/12 , C08F16/06 , C08F8/00 , B82Y5/00
CPC分类号： C08B37/0006 , A61K9/00 , A61K9/1652 , A61K38/02 , A61K38/16 , A61K39/00 , A61K39/0011 , A61K39/385 , A61K39/395 , A61K45/06 , A61K47/48 , A61K47/6939 , A61K2039/55555 , A61K2039/55561 , A61L17/10 , A61L17/145 , A61L27/14 , A61L27/34 , A61L27/58 , A61L31/10 , A61L31/148 , B82Y5/00 , C08B30/18 , C08B37/0021 , C08B37/14 , C08F8/00 , C08F8/28 , C08F16/06 , C08L1/02 , C08L1/08 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/06 , C08L101/02 , C09D129/14
摘要： Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications.
摘要翻译： 制备改性多羟基化聚合物的组合物和方法，其包含具有可逆地改性羟基的多羟基化聚合物，由此羟基通过聚羟基化聚合物和试剂如缩醛，醛，乙烯基醚和酮之间的酸催化反应而被改性，使得 改性的多羟基化聚合物变得不溶于水，但可溶于普通的有机溶剂，容易制备酸敏感的材料。 可以使由这些聚合物制成的材料以pH依赖的方式降解。 疏水和亲水性货物都分别使用单和双乳液技术装载到由本发明聚合物制成的颗粒中。 由于其易于制备，加工性，pH敏感性和生物相容性，本发明的改性多羟基化聚合物应用于许多药物递送应用中。
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