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    Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices
    2.
    发明授权
    Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices 有权
    用于微流体装置的多孔聚合物整料和热塑性聚合物的光引发接枝

    公开(公告)号：US07431888B2

    公开(公告)日：2008-10-07

    申请号：US10665900

    申请日：2003-09-19

    申请人： Jean M. J. Frechet ,  Frantisek Svec ,  Thomas Rohr

    发明人： Jean M. J. Frechet ,  Frantisek Svec ,  Thomas Rohr

    IPC分类号： B01L3/02

    CPC分类号： B01L3/502707 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/16 ,  Y10T436/2575

    摘要： A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.

    摘要翻译： 优选由热塑性聚合物制成的微流体装置，该微流体装置包括通道或多个通道，其表面通过光栅改性而被修饰。 该装置还包括通过通道内的UV引发聚合制备的多孔聚合物整料，以及使用光栅功能化整体的孔表面。 阐述了制备热塑性聚合物和多孔聚合物整料的这种表面改性的方法。

    Dendritic based macromolecules
    3.
    发明授权
    Dendritic based macromolecules 失效
    基于树枝状的大分子

    公开(公告)号：US07101937B1

    公开(公告)日：2006-09-05

    申请号：US08422627

    申请日：1995-04-14

    申请人： Jean M. J. Frechet ,  Craig J. Hawker ,  Karen Wooley

    发明人： Jean M. J. Frechet ,  Craig J. Hawker ,  Karen Wooley

    IPC分类号： C08F255/00

    CPC分类号： C08G83/003 ,  C08G81/00

    摘要： Macromolecules in the shape of three-dimensional kites, barbells, and other shapes are disclosed. The shaped macromolecules are prepared the reaction of one or more dendritic polymers and a linear polymer. The kite-shaped macromolecules are dendritic polymers attached at either their focal points or at an outer to a long carbon chain group. The barbell macromolecules have dendritic polymers at either end of the molecule, which polymers are connected together through the focal points of each by a suitable connecting substituent such as a linear polymer. The shaped macromolecules are used in specialty medical and technological applications including such as drug delivery agents, imaging materials, molecular devices, thin film devices, surface modifiers, transport agents, compatibilizers, rheology control agents, molecular ball bearings, molecular dipoles, non-linear optical materials, medical imaging agents, membrane and cell modifiers, complexing agents, adhesives, interface strengthening agents, and the like.

    摘要翻译： 公开了三维风筝，杠铃和其他形状的大分子。 形成的大分子是制备一种或多种树枝状聚合物和线性聚合物的反应。 风筝形大分子是在其焦点附近或在长碳链基团外部连接的树枝状聚合物。 杠铃大分子在分子的任一端具有树枝状聚合物，该聚合物通过各自的焦点通过适当的连接取代基如线性聚合物连接在一起。 成型的大分子用于特殊医疗和技术应用，包括药物递送剂，成像材料，分子装置，薄膜​​装置，表面改性剂，输送剂，增容剂，流变控制剂，分子球轴承，分子偶极子，非线性 光学材料，医学成像剂，膜和细胞改性剂，络合剂，粘合剂，界面强化剂等。

    Metalation and functionalization of polymers and copolymers
    4.
    发明授权
    Metalation and functionalization of polymers and copolymers 失效
    聚合物和共聚物的金属化和官能化

    公开(公告)号：US5670581A

    公开(公告)日：1997-09-23

    申请号：US476753

    申请日：1995-06-07

    申请人： Jean M. J. Frechet ,  Shah A. Haque ,  Joachim Hans Georg Steinke ,  Hsien-Chang Wang

    发明人： Jean M. J. Frechet ,  Shah A. Haque ,  Joachim Hans Georg Steinke ,  Hsien-Chang Wang

    IPC分类号： C08F8/00 ,  C08F8/42

    CPC分类号： C08F8/42 ,  C08F8/00 ,  C08F2800/10 ,  C08F2810/30 ,  C08F2810/50

    摘要： There is provided a method of introducing functionality into a copolymer of an isoolefin and an alkylstyrene at the alkylbenzyl carbon atom comprising the steps of: forming a solution of said copolymer in a hydrocarbon solvent; adding to said polymer solution an alkali metal Cs, K, Na alkoxide and an alkyl lithium compound to form a superbase with the polymer solution; and adding an electrophile to said base polymer solution also provided are the metalated copolymers and the functionalized derivative therefrom.

    摘要翻译： 提供了在烷基苄基碳原子上将官能度引入异烯烃和烷基苯乙烯的共聚物的方法，包括以下步骤：在烃溶剂中形成所述共聚物的溶液; 向所述聚合物溶液中加入碱金属Cs，K，醇钠和烷基锂化合物以与所述聚合物溶液形成超基; 还向所述基础聚合物溶液中加入亲电试剂也是金属化共聚物和由其衍生的官能化衍生物。

    Polymerizable macromonomers and polymers prepared therefrom
    5.
    发明授权
    Polymerizable macromonomers and polymers prepared therefrom 失效
    可聚合的大分子单体和由其制备的聚合物

    公开(公告)号：US5635571A

    公开(公告)日：1997-06-03

    申请号：US660684

    申请日：1996-06-05

    申请人： Jean M. J. Frechet ,  Koji Yui

    发明人： Jean M. J. Frechet ,  Koji Yui

    IPC分类号： A61K47/48 ,  C08F290/06 ,  C08G73/02 ,  C08G73/04 ,  C08G83/00 ,  C08L79/04 ,  C08G73/06

    CPC分类号： C08G83/005 ,  A61K47/48207 ,  C08F290/06 ,  C08G73/0233

    摘要： Polyoxazolines having the structural formula: ##STR1## wherein R is phenylene or alkylene containing 2 to 18 carbon atoms, R.sup.2 is C.sub.1-4 alkyl and R.sub.1 is selected from the group consisting of C.sub.1-12 alkyl, vinyl, isopropylidene, pentafluoroethyl, phenyl, hydroxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups, C.sub.1-2 -alkoxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups and .paren open-st.CH.sub.2 CH.sub.2 --O.paren close-st..sub.r CH.sub.3 in which r ranges from 1-20, X is NH.sub.2 or OH, n ranges from 2 to 50 and m ranges from 0 to 50, wherein R.sub.1 is hydroxyphenyl optionally interrupted by up to 20 ethylene oxide groups only when X is NH.sub.2, are polymerizable to form hyperbranched polymers which have a number average molecular weight ranging from 5,000 to 150,000, a weight average molecular weight ranging from 5,500 to 5,000,000 and a polydispersity ranging from 1.1 to 300 and which are very polar and highly wettable and are useful as adhesives, biodegradable materials, biomaterials, carriers for chemicals, carriers for image contrast agents, coatings, components of blends, components of medical imaging formulations, crosslinkers, dispersants, drug carriers, imaging materials, resists for lighography, slow release agents, vectors for gene therapy, and viscosity modifiers.

    摘要翻译： 具有以下结构式的聚恶唑啉：其中R是亚苯基或含2至18个碳原子的亚烷基，R 2是C 1-4烷基，R 1选自C 1-12烷基，乙烯基，异亚丙基，五氟乙基 ，任选地被多达20个环氧乙烷基团间隔的苯基，羟基苯基，任选地被多达20个环氧乙烷基团间隔的C 1-2 - 烷氧基苯基和+545个CH 2 CH 2 -O + 546 rCH 3，其中r在1-20， X为NH 2或OH，n为2至50，m为0至50，其中R 1为仅在X为NH 2时任选地被至多20个环氧乙烷基团间隔的羟基苯基，可聚合形成数均分子量的超支化聚合物 分子量为5,000至150,000，重均分子量为5,500至5,000,000，多分散性为1.1至300，非极性和高度可湿性，可用作粘合剂，可生物降解材料，生物材料，载体 用于化学品，图像造影剂的载体，涂料，共混物组分，医学成像制剂的组分，交联剂，分散剂，药物载体，成像材料，用于光刻的抗蚀剂，缓释剂，用于基因治疗的载体和粘度调节剂。