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1.发明授权Method for identifying a substance which mediates interaction between interleukin 22 and an interleukin 22 receptor 失效用于鉴定介导白细胞介素22与白细胞介素22受体之间相互作用的物质的方法公开(公告)号：US07846652B2
公开(公告)日：2010-12-07
申请号：US11491761
申请日：2006-07-24
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/68 , C07K14/54 , C07K14/705 , C07K14/715
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/54 , C07K14/7155 , C07K16/18 , C07K16/44 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/505 , G01N33/566 , G01N2333/715 , G01N2333/91215 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要： Interleukin-22 interacts with its receptor, referred to as IL-22R, and instigates a series of reactions, leading to activation of various molecules, such as JAK-1, Tyk2, and others. One can identify molecules which mediate this interaction by measuring the activity of one or more of the molecules in the pathway, to identify agonists and antagonists. These, in turn, are useful therapeutic agents, where inappropriate expression of one of the activated molecules is at issue, and requires amelioration.
摘要翻译： 白细胞介素-22与其受体相互作用，称为IL-22R，并引起一系列反应，导致各种分子的活化，如JAK-1，Tyk2等。 人们可以通过测量途径中一种或多种分子的活性，鉴定激动剂和拮抗剂来鉴定介导这种相互作用的分子。 这些又是有用的治疗剂，其中一种活化分子的不适当表达是有争议的，并且需要改善。
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公开(公告)号：US20060257408A1
公开(公告)日：2006-11-16
申请号：US11491761
申请日：2006-07-24
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/54 , C07K14/7155 , C07K16/18 , C07K16/44 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/505 , G01N33/566 , G01N2333/715 , G01N2333/91215 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要： Interleukin-22 interacts with its receptor, referred to as IL-22R, and instigates a series of reactions, leading to activation of various molecules, such as JAK-1, Tyk2, and others. One can identify molecules which mediate this interaction by measuring the activity of one or more of the molecules in the pathway, to identify agonists and antagonists. These, in turn, are useful therapeutic agents, where inappropriate expression of one of the activated molecules is at issue, and requires amelioration.
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3.发明授权Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof 失效编码T细胞诱导因子（TIF）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US07972833B2
公开(公告)日：2011-07-05
申请号：US11902473
申请日：2007-09-21
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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4.发明授权Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses therefor 失效编码T细胞诱导因子（TIFs）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US06359117B1
公开(公告)日：2002-03-19
申请号：US09354243
申请日：1999-07-16
IPC分类号： C07K1452
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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5.发明申请Isolated Soluble IL-TIF/IL-22 Receptor or Binding Protein Which Binds to IL-TIF/IL-22 and Uses Thereof 审中-公开与IL-TIF / IL-22结合的分离的可溶性IL-TIF / IL-22受体或结合蛋白及其用途公开(公告)号：US20090311802A1
公开(公告)日：2009-12-17
申请号：US12512909
申请日：2009-07-30
IPC分类号： G01N33/566 , C07K16/00
CPC分类号： C07K14/7155 , C07H21/04
摘要： The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
摘要翻译： 本发明涉及与称为IL-TIF / IL-22的分子结合的可溶性蛋白质。 蛋白质可以拮抗IL-TIF / IL-22对靶细胞的作用。 还描述了编码蛋白质的核酸分子以及蛋白质的用途。
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6.发明申请Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof 失效编码T细胞诱导因子（TIF）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US20080213881A1
公开(公告)日：2008-09-04
申请号：US11902473
申请日：2007-09-21
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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7.发明授权公开(公告)号：US07081528B2
公开(公告)日：2006-07-25
申请号：US09751797
申请日：2000-12-29
IPC分类号： C07H21/04
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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公开(公告)号：US20050282215A1
公开(公告)日：2005-12-22
申请号：US11184399
申请日：2005-07-19
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to new members of the Class II cytokine receptor family, such as LICR-2. The new member binds to AK155, and mediates STAT activation.
摘要翻译： 本发明涉及II类细胞因子受体家族的新成员，例如LICR-2。 新成员结合AK155，并介导STAT激活。
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9.发明授权Isolated nucleic acid molecules which encode T cell inducible factors (TIFS), the proteins encoded, and uses thereof 失效编码T细胞诱导因子（TIFS）的分离的核酸分子，编码的蛋白质及其用途公开(公告)号：US06331613B1
公开(公告)日：2001-12-18
申请号：US09419568
申请日：1999-10-18
IPC分类号： C07H2104
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
摘要翻译： 本发明涉及分离核酸分子，其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外，还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。
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10.发明授权Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof 失效编码结合IL-TIF / IL-22的可溶性IL-TIF受体或结合蛋白的分离的核酸分子及其用途公开(公告)号：US07268223B2
公开(公告)日：2007-09-11
申请号：US09919162
申请日：2001-07-31
IPC分类号： C07H21/04
CPC分类号： C07K14/7155 , A01K2217/05 , A61K38/00 , C07K2319/30
摘要： The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
摘要翻译： 本发明涉及与称为IL-TIF / IL-22的分子结合的可溶性蛋白质。 蛋白质可以拮抗IL-TIF / IL-22对靶细胞的作用。 还描述了编码蛋白质的核酸分子以及蛋白质的用途。
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