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公开(公告)号：US20060149045A1
公开(公告)日：2006-07-06
申请号：US10538993
申请日：2003-12-18
申请人： Jean-Claude Braekman , Eric Quaquebeke , Laurent Ingrassia , Janique Dewelle , Robert Kiss , Francis Darro
发明人： Jean-Claude Braekman , Eric Quaquebeke , Laurent Ingrassia , Janique Dewelle , Robert Kiss , Francis Darro
摘要： The present invention relates to novel steroid compounds of Formula (IB) having anti-tumor activity. The present invention also relates to a method for the preparation of said steroid compounds. The invention further relates to a pharmaceutical composition comprising an effective amount of said steroid compounds. Furthermore, the present invention concerns the use of said steroid compounds as a medicament and in the preparation of a medicament for the treatment of cancer. The present invention also relates to the use of a steroid compound or a pharmaceutical composition comprising said steroid compound according to the invention in the treatment of cancer.
摘要翻译： 本发明涉及具有抗肿瘤活性的式（IB）的新型类固醇化合物。 本发明还涉及一种制备所述类固醇化合物的方法。 本发明还涉及包含有效量的所述类固醇化合物的药物组合物。 此外，本发明涉及所述类固醇化合物作为药物和制备用于治疗癌症的药物的用途。 本发明还涉及包含根据本发明的所述类固醇化合物的类固醇化合物或药物组合物在治疗癌症中的用途。
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公开(公告)号：US20070123473A1
公开(公告)日：2007-05-31
申请号：US10582121
申请日：2004-12-17
申请人： Jean-Claude Braekman , Laurent Ingrassia , Prosper Nshimyumukiza , Eric Van Quaquebeke , Janique Dewelle , Laurent Van Den Hove , Robert Kiss , Francis Darro
发明人： Jean-Claude Braekman , Laurent Ingrassia , Prosper Nshimyumukiza , Eric Van Quaquebeke , Janique Dewelle , Laurent Van Den Hove , Robert Kiss , Francis Darro
IPC分类号： A61K31/704 , A61K31/58 , C07J43/00
CPC分类号： C07J43/00
摘要： Glycosylated steroid compounds having anti-migratory activity and methods for their preparation are disclosed. Pharmaceutical compositions having an effective amount of the glycosylated steroid compounds are also disclosed. The glycosylated steroid compounds may be used as a medicament. Preparation of medicaments containing the glycosylated steroid compounds for treatment of diseases associated with cell migration, in particular, cancer, are disclosed. The glycosylated steroid compounds or pharmaceutical compositions containing the glycosylated steroid compounds may be used in the treatment of diseases associated with cell migration, in particular for the treatment of cancer.
摘要翻译： 公开了具有抗迁移活性的糖基化类固醇化合物及其制备方法。 还公开了具有有效量的糖基化类固醇化合物的药物组合物。 糖基化类固醇化合物可以用作药物。 公开了含有用于治疗与细胞迁移相关的疾病，特别是癌症的糖基化类固醇化合物的药物的制备。 含有糖基化类固醇化合物的糖基化类固醇化合物或药物组合物可用于治疗与细胞迁移有关的疾病，特别是用于治疗癌症。
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公开(公告)号：US20060166952A1
公开(公告)日：2006-07-27
申请号：US10530904
申请日：2003-10-09
申请人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″oxo-voruscharin compound or derivatives thereof. The disclosed 2″oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2''oxo-voruscharin化合物及其衍生物以及包含2''oxo-voruscharin化合物或其衍生物的药物组合物。 所公开的2''oxo-voruscharin化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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公开(公告)号：US07981875B2
公开(公告)日：2011-07-19
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包括2“氧代 - 罗香兰和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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公开(公告)号：US20080261935A1
公开(公告)日：2008-10-23
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , A61P35/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包含2'-氧代 - 罗瑞沙林和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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公开(公告)号：US07320971B2
公开(公告)日：2008-01-22
申请号：US10530904
申请日：2003-10-09
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″ oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2'-氧代 - 罗红沙星化合物及其衍生物，以及包含2'-氧代 - 罗喋呤化合物或其衍生物的药物组合物。 所公开的2'' - 氧化 - 罗瑞沙林化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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公开(公告)号：US20060057237A1
公开(公告)日：2006-03-16
申请号：US10530905
申请日：2003-10-09
申请人： Francis Darro , Jean-Claude Braekman , Pierre Guissou , Odile Nacoulma , Mohamed El Yazidi , Janique Dewelle , Rob Van Ginkel , Marc Van Damme , Robert Kiss
发明人： Francis Darro , Jean-Claude Braekman , Pierre Guissou , Odile Nacoulma , Mohamed El Yazidi , Janique Dewelle , Rob Van Ginkel , Marc Van Damme , Robert Kiss
IPC分类号： A61K36/185
CPC分类号： A61K36/27
摘要： Extracts of the plant Calotropis procera, having a pharmacological activity, in particular an anti-poisonous activity, and active compounds isolated thereof are described. Furthermore, methods for the extraction of the extracts are disclosed. Also, a pharmaceutical composition or product for the treatment of cancer which includes an effective amount of the described extracts or an active compound thereof, a therapeutic compound and optionally a pharmaceutical acceptable carrier are described.
摘要翻译： 描述了具有药理学活性，特别是抗毒活性的植物提取物及其分离的活性化合物。 此外，公开了提取提取物的方法。 此外，还描述了包含有效量的所述提取物或其活性化合物，治疗化合物和任选的药学上可接受的载体的用于治疗癌症的药物组合物或产品。
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8.发明申请ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES 审中-公开具有抗增生活性和抗活性活性的异烟碱碱性阿片碱衍生物公开(公告)号：US20100076005A1
公开(公告)日：2010-03-25
申请号：US12445405
申请日：2007-10-12
申请人： Laurent Ingrassia , Lise Wlodarczak , Stephanie Thomas , Eric Van Quaquebeke , Laurent Van den Hove , Robert Kiss , Francis Darro
发明人： Laurent Ingrassia , Lise Wlodarczak , Stephanie Thomas , Eric Van Quaquebeke , Laurent Van den Hove , Robert Kiss , Francis Darro
IPC分类号： A61K31/4355 , C07D491/02 , A61P35/04
CPC分类号： C07D491/06
摘要： Isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities are disclosed. In particular, compounds of formula (I) or (II), as well as stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, pharmaceutically acceptable salt and/or solvate are encompassed which are useful in the treatment and prophylaxis of cancer. Methods of preparation are also disclosed.
摘要翻译： 公开了具有抗增殖和抗迁移活性的异卡波斯特尔生物碱衍生物。 特别地，包括可用于治疗和预防癌症的式（I）或（II）的化合物以及立体异构体，互变异构体，外消旋体，前药，其代谢物，药学上可接受的盐和/或溶剂合物。 还公开了制备方法。
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9.发明申请Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom 失效Azonafide衍生物，其生产方法和药物组合物公开(公告)号：US20080292585A1
公开(公告)日：2008-11-27
申请号：US12093086
申请日：2006-11-09
IPC分类号： A61K38/21 , C07D221/18 , A61P35/00 , A61K31/473
CPC分类号： C07D405/12 , C07D221/18 , C07D401/12 , C07D417/12
摘要： Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of Cancer.
摘要翻译： 唑酮衍生物是通过使唑酮与醛，酰基卤，硫代酰卤，单异氰酸酯，异硫氰酸酯，磺酰卤，单卤代烷烃，单卤代烯烃或单卤代炔反应而得到的，并且可用作预防和治疗细胞增殖性疾病的药物组合物的活性成分 几种形式的癌症。
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10.发明授权公开(公告)号：US07741337B2
公开(公告)日：2010-06-22
申请号：US12093086
申请日：2006-11-09
IPC分类号： A61K31/473 , C07D221/18
CPC分类号： C07D405/12 , C07D221/18 , C07D401/12 , C07D417/12
摘要： The present invention is directed to azonafide derivatives obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of cancer.
摘要翻译： 本发明涉及通过使azonafide与醛，酰卤，硫代酰卤，单异氰酸酯，异硫氰酸酯，磺酰卤，单卤代烷烃，单卤代烯烃或单卤代炔反应得到的azonafide衍生物，可用作预防和治疗细胞的药物组合物的活性成分 增殖性疾病，特别是几种形式的癌症。
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