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72 条记录 (耗时 0.037 秒)

    Octahydro-2H-pyrido[1,2-a]pyrazine compounds
    3.
    发明授权
    Octahydro-2H-pyrido[1,2-a]pyrazine compounds 失效
    八氢-2H-吡啶并[1,2-a]吡嗪化合物

    公开(公告)号：US06992085B2

    公开(公告)日：2006-01-31

    申请号：US10195019

    申请日：2002-07-12

    申请人： Solo Goldstein ,  Guillaume Poissonnet ,  Jean-Gilles Parmentier ,  Pierre Lestage ,  Brian Lockhart

    发明人： Solo Goldstein ,  Guillaume Poissonnet ,  Jean-Gilles Parmentier ,  Pierre Lestage ,  Brian Lockhart

    IPC分类号： A61K31/4985 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： A compound selected from those of formula (I): wherein: Ra represents linear or branched (C1–C6)alkylene, X represents a group selected from W1, —C(W1)—W2—, —W2—C(W1)—, —W2—C(W1)W2—, —W2—Ra— and —CH(OR1)— wherein W1, W2 and R1 are as defined in the description, when Y represents aryl or heteroaryl, or X represents a group selected from single bond, —C(W1)—, —W2—C(W1)—, —W2—Ra and —CH(OR1)— wherein W1, W2, Ra and R1 are as defined hereinbefore, when Y represents a fused bicyclic group, of formula: wherein: A represents nitrogen-containing heterocycle having from 4 to 7 ring members that is unsaturated or partially saturated and optionally contains a second hetero atom, B represents phenyl ring optionally substituted by one or more groups as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the treatment of cognitive deficiencies.

    摘要翻译： 选自式（I）的化合物：其中：R a表示直链或支链（C 1 -C 6 -C 6）亚烷基，X表示选自W SUB -C（W 1） - W 2 - ， - W 2 -C（W 1） ） - ，-W 2 -C（W 1）W 2 - ， - W 2

    2-(1H) quinolinone compounds
    4.
    发明授权
    2-(1H) quinolinone compounds 失效
    2-（1H）喹啉酮化合物

    公开(公告)号：US5776949A

    公开(公告)日：1998-07-07

    申请号：US889920

    申请日：1997-07-10

    申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

    IPC分类号： A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D215/36 ,  C07D401/04 ,  C07D471/04 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D215/36 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D471/04

    摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.

    摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者， 当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与 药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。

    Morpholine compounds, compositions and use
    5.
    发明授权
    Morpholine compounds, compositions and use 失效
    吗啉化合物，组成和用途

    公开(公告)号：US5026701A

    公开(公告)日：1991-06-25

    申请号：US603522

    申请日：1990-10-25

    申请人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol ,  Pierre Lestage

    发明人： Gilbert Regnier ,  Claude Guillonneau ,  Jean Lepagnol ,  Pierre Lestage

    IPC分类号： A61K31/535 ,  A61P9/08 ,  A61P25/28 ,  C07D413/12

    CPC分类号： C07D413/12 ,  Y10S514/878 ,  Y10S514/879

    摘要： New morpholine compounds of the formula: ##STR1## in which: X, bonded to the aromatic nucleus, represents halogen or trifluoromethyl and R' represents hydrogen, (C.sub.1 -C.sub.5)alkyl optionally including a double bond, or aralkyl; in racemic and enantiomeric forms, and physiologically tolerable acid addition salts theroef.These compounds and their physiologically tolerable salts can be used therapeutically especially in the treatment of ischaemic syndromes and cerebral ageing.

    摘要翻译： 下式的新的吗啉化合物：其中：与芳香核键合的X表示卤素或三氟甲基，R'表示氢，任选地包括双键的（C 1 -C 5）烷基或芳烷基; 外消旋和对映异构体形式，以及生理上可耐受的酸加成盐。 这些化合物及其生理上可耐受的盐可用于治疗特别是治疗缺血综合征和脑衰老。

    Azabicylic compounds, a process for their preparation and pharmaceutical compositions containing them
    6.
    发明授权
    Azabicylic compounds, a process for their preparation and pharmaceutical compositions containing them 失效
    Azabicylic化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US07906547B2

    公开(公告)日：2011-03-15

    申请号：US12456165

    申请日：2009-06-12

    申请人： Patrick Casara ,  Anne-Marie Chollet ,  Alain Dhainaut ,  Pierre Lestage ,  Fany Panayi ,  Anita Roger

    发明人： Patrick Casara ,  Anne-Marie Chollet ,  Alain Dhainaut ,  Pierre Lestage ,  Fany Panayi ,  Anita Roger

    IPC分类号： A61K31/403 ,  C07D209/52

    CPC分类号： C07D209/52

    摘要： Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group selected from wherein R and R′ are as defined in the description. Medicinal products containing the same which are useful in the treatment of cognitive and psycho-behavioural disorders associated with cerebral ageing, with neurodegenerative diseases or with cranial traumas and also in the treatment of mood disorders, of schizophrenia and of cognitive disorders associated therewith, of sleep disorders, of sleep-waking rhythm disorders, of attention-deficit hyperactivity syndrome or of obesity.

    摘要翻译： 式（I）化合物：其中：ALK表示亚烷基链，W表示选自其中R和R'如说明书中所定义的基团。 含有相同的药用产品，其可用于治疗与脑衰老相关的认知和心理行为障碍，神经变性疾病或颅外伤，以及治疗精神分裂症和与其相关的认知障碍的情绪障碍，睡眠 睡眠障碍，节律障碍，注意力缺陷多动症或肥胖症。

    Benzothiazine and benzothiadiazine compounds
    10.
    发明申请
    Benzothiazine and benzothiadiazine compounds 失效
    苯并噻嗪和苯并噻二嗪化合物

    公开(公告)号：US20070249594A1

    公开(公告)日：2007-10-25

    申请号：US11823439

    申请日：2007-06-27

    申请人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

    发明人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

    IPC分类号： A61K31/549 ,  A61K31/554 ,  C07D279/16 ,  C07D285/22

    CPC分类号： C07D513/04

    摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.

    摘要翻译： 式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示 氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。 含有该药物的药物可用于治疗AMPA系统的病症。