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8 条记录 (耗时 0.021 秒)

    Glycylanilide derivatives, their preparation and their application in therapy
    3.
    发明授权
    Glycylanilide derivatives, their preparation and their application in therapy 失效
    甘氨酰苯胺衍生物，其制备及其在治疗中的应用

    公开(公告)号：US5760087A

    公开(公告)日：1998-06-02

    申请号：US875191

    申请日：1997-07-17

    申请人： Jean-Francois Patoiseau ,  Jean-Marie Autin ,  Andre Delhon ,  Philippe Oms

    发明人： Jean-Francois Patoiseau ,  Jean-Marie Autin ,  Andre Delhon ,  Philippe Oms

    IPC分类号： A61K31/165 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C231/02 ,  C07C237/22 ,  C07C323/60 ,  A01N37/18

    CPC分类号： C07C237/22 ,  C07C323/60

    摘要： The invention relates to new derivatives of glycylanilides having general formula (I), wherein, particularly, R.sub.1, R.sub.3, R.sub.4, R.sub.8, R.sub.9 represent CH.sub.3 ; R.sub.2, R.sub.5, R.sub.6, R.sub.7 represent H; R.sub.10 represents C.sub.12 H.sub.25 and A is a sulfur atom. It also relates to the preparation process and the pharmaceutical compositions comprising as active principle at least one of said compounds, as well as the utilization of said derivatives for the fabrication of drugs intended to the treatment of hypercholesterolemy or atherosclerosis. ##STR1##

    摘要翻译： PCT No.PCT / FR96 / 00081 Sec。 371日期1997年7月17日 102（e）日期1997年7月17日PCT 1996年1月18日PCT PCT。 第WO96 / 22279号公报 日期：1996年7月25日本发明涉及具有通式（I）的脯氨酰苯胺的新衍生物，其中，特别地，R 1，R 3，R 4，R 8，R 9表示CH 3; R2，R5，R6，R7表示H; R 10表示C12H25，A为硫原子。 它还涉及制备方法和药物组合物，其包含作为至少一种所述化合物的活性成分，以及所述衍生物用于制备旨在治疗高胆固醇血症或动脉粥样硬化的药物的用途。 （一）

    1,2,4-Triazine Derivatives, Preparation and Use Thereof in Human Therapy
    4.
    发明申请
    1,2,4-Triazine Derivatives, Preparation and Use Thereof in Human Therapy 有权

    公开(公告)号：US20080167313A1

    公开(公告)日：2008-07-10

    申请号：US11885630

    申请日：2006-03-02

    申请人： Elisabeth Dupont-Passelaigue ,  Isabelle Leroy ,  Jean-Francois Patoiseau ,  Didier Junquero ,  Yves Rival ,  Andre Delhon

    发明人： Elisabeth Dupont-Passelaigue ,  Isabelle Leroy ,  Jean-Francois Patoiseau ,  Didier Junquero ,  Yves Rival ,  Andre Delhon

    IPC分类号： A61K31/53 ,  C07D253/06 ,  A61P3/06 ,  A61P3/04 ,  A61P3/10 ,  A61P17/00

    CPC分类号： C07D253/075

    摘要： The invention concerns 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a branched or linear C1-C7 alkyl or alkenyl radical, a C1-C6 alkyl radical substituted by groups such as trifluoromethyl, C5-C6 cycloalkyl, nitrile, C1-C4 alkoxycarbonylvinyl, hydroxycarbonylvinyl, C1-C4 alkoxycarbonyl, carboxylate, benzyloxy or phenyl (for which the phenyl ring is optionally substituted by one or more groups such as C1-C4 alkoyl, C1-C4 alkoxy, nitro, halogen, trifluoromethyl); YR3 represents oxygen or NR3 for which R3 represents hydrogen, a linear or branched C1-C7 alkyl or alkenyl radical, a C1-C6 alkyl radical substituted by groups such as trifluoromethyl or phenyl (for which the phenyl ring is optionally substituted by one or more groups such as C1-C4 alkoyl, C1-C4 alkoxy, nitro, halogen, trifluoromethyl); Z represents an oxygen atom or a carbon atom capable of being bound to the ortho, meta or para positions of the phenyl group of formula I; n can be 0 to 5 when Z=C or 2 to 4 when Z=O; X represents oxygen or sulphur; R4, R5, R6, R7 and R8 represent hydrogen or fluorine; R9, R10 and R11 represent hydrogen or a linear or branched C1-C5 alkyl group as well as the pharmaceutically acceptable base addition salts, and the various enantiomers of compounds having asymmetric carbons, and their mixtures in all proportions including in particular the racemic mixtures.

    Method of reducing cholesterol using certain aromatic keto acids
    8.
    发明授权
    Method of reducing cholesterol using certain aromatic keto acids 失效
    使用某些芳香族酮酸降低胆固醇的方法

    公开(公告)号：US4008323A

    公开(公告)日：1977-02-15

    申请号：US560344

    申请日：1975-03-21

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Jean-Pierre Rieu ,  Andre Delhon

    IPC分类号： C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07D295/185 ,  A61K31/495 ,  A61K31/19 ,  A61K31/205 ,  A61K31/235

    CPC分类号： C07D295/185 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90

    摘要： This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. This application claims their hypocholesterolemic use.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic acitvity and having the general formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, alkyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy. R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl. R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene.When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.4 may be OH, alkoxy, ##STR2## The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess chloresterol.

    摘要翻译： 本发明涉及可用作药物的新化合物，以及含有该化合物的药物组合物。 本申请要求其低胆固醇血症用途。