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1.发明授权Apparatus for parallel detection of the behaviour of mechanical micro-oscillators 失效用于并行检测机械微振荡器行为的装置公开(公告)号：US07173714B2
公开(公告)日：2007-02-06
申请号：US10415984
申请日：2001-11-05
IPC分类号： G01B9/02
CPC分类号： G02B21/00 , B82Y35/00 , G01N29/036 , G01N2291/0256
摘要： The invention concerns an apparatus for parallel detection of the behaviour of mechanical micro-oscillators interacting with the sample (21). The amplitude and the phase of resonance of micro-oscillators (12) are measured with optical means. The invention is characterised in that a source (1) is active during a fraction 1/n of the period (n being an integer) and of variable phase p/n of the period (p being an integer). Interferences are produced between light beams generated by reflection of incident light beams (7) and (8) on the micro-oscillators (12). Periodically the micro-oscillators (12) are displaced by means. The value of the parameter p (p being an integer) is varied and N elementary measurements are integrated to obtain a measurement representing each of the values of p. The phase and amplitude of each micro-oscillator (12) are calculated on the basis of the representative data obtained for each value of p and this for a large number of accumulations. The invention is applicable in the field of nanotechnologies.
摘要翻译： 本发明涉及用于并行检测与样品（21）相互作用的机械微振荡器的行为的装置。 用光学方法测量微振荡器（12）的振幅和相位。 本发明的特征在于，在周期（n为整数）的分数1 / n和周期的可变相位p / n（p为整数）的数量级中，源（1）是有效的。 在微振荡器（12）上的入射光束（7）和（8）的反射产生的光束之间产生干扰。 定期地，微振荡器（12）通过装置移位。 参数p（p是整数）的值是变化的，并且积分N个基本测量值以获得表示p的每个值的测量值。 每个微振荡器（12）的相位和振幅都是根据为每个p值获得的代表性数据计算出来的，而且这对于大量的累加来计算。 本发明适用于纳米技术领域。
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2.发明授权Device for the actively-controlled and localized deposition of at least one biological solution 有权用于主动控制和局部沉积至少一种生物溶液的装置公开(公告)号：US08617406B2
公开(公告)日：2013-12-31
申请号：US13295441
申请日：2011-11-14
申请人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
发明人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
IPC分类号： C23F1/00
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/12 , B01L2300/0627 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , Y10T29/49996
摘要： The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device includes at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.
摘要翻译： 本发明涉及用于主动控制生物溶液微滴沉积的装置。 本发明的装置包括至少一个扁平硅杆，其包括中心体和形成点的端部区域，在所述点上设置狭缝或凹槽。 本发明的特征在于它还包括至少一个金属轨道，其设置在中心体的一个面上并且至少部分地沿着所述狭缝或凹槽延伸。 本发明还涉及一种制造本发明的装置的方法以及使用所述装置主动控制的生物溶液微滴沉积和取样的方法。
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公开(公告)号：US06930365B2
公开(公告)日：2005-08-16
申请号：US10475324
申请日：2002-04-25
CPC分类号： G01N29/036 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01L3/5085 , B81B3/0018 , C40B60/14 , G01N2291/0256
摘要： The invention relates to a biosensor matrix comprising a substrate made of semiconductor material. It has a main plane surface and cavities formed in a surface opposite from said plane surface to define between the bottoms of said cavities and the main plane surface deformable structure each including at least one piezoresistive or piezoelectric sensing element. The method of manufacture implements fabrication techniques specific to micro- and nanotechnologies, preferably with localized pre-amorphization of the surface of the substrate prior to implantation of piezoelectric elements, which implantation is followed by annealing.
摘要翻译： 本发明涉及包含由半导体材料制成的衬底的生物传感器矩阵。 它具有形成在与所述平面相对的表面中的主平面表面和空腔，以限定在所述空腔的底部和主平面表面可变形结构之间，每个包括至少一个压阻或压电传感元件。 制造方法实现了微型和纳米技术特有的制造技术，优选地在植入压电元件之前对衬底的表面进行局部预非晶化，随后进行退火。
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4.发明申请Device for the Actively-Controlled and Localized Deposition of at Least One Biological Solution 有权用于至少一种生物解决方案的主动控制和定位沉积的装置公开(公告)号：US20120111129A1
公开(公告)日：2012-05-10
申请号：US13295441
申请日：2011-11-14
申请人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
发明人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/12 , B01L2300/0627 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , Y10T29/49996
摘要： The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device includes at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.
摘要翻译： 本发明涉及用于主动控制生物溶液微滴沉积的装置。 本发明的装置包括至少一个扁平硅杆，其包括中心体和形成点的端部区域，在所述点上设置狭缝或凹槽。 本发明的特征在于它还包括至少一个金属轨道，其设置在中心体的一个面上并且至少部分地沿着所述狭缝或凹槽延伸。 本发明还涉及一种制造本发明的装置的方法以及使用所述装置主动控制的生物溶液微滴沉积和取样的方法。
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5.发明授权Device for the actively-controlled and localised deposition of at least one biological solution 有权用于主动控制和局部沉积至少一种生物溶液的装置公开(公告)号：US08079832B2
公开(公告)日：2011-12-20
申请号：US10514583
申请日：2003-05-15
申请人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoît Belier , Jean-Bernard Pourciel
发明人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoît Belier , Jean-Bernard Pourciel
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/12 , B01L2300/0627 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , Y10T29/49996
摘要： The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device consists of at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.
摘要翻译： 本发明涉及用于主动控制生物溶液微滴沉积的装置。 本发明的装置包括至少一个平的硅杆，其包括中心体和形成点的端部区域，设置在所述点上的缝隙或凹槽。 本发明的特征在于它还包括至少一个金属轨道，其设置在中心体的一个面上并且至少部分地沿着所述狭缝或凹槽延伸。 本发明还涉及一种制造本发明的装置的方法以及使用所述装置主动控制的生物溶液微滴沉积和取样的方法。
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6.发明申请Device for the actively-controlled and localised deposition of at least one biological solution 有权用于主动控制和局部沉积至少一种生物溶液的装置公开(公告)号：US20060096078A1
公开(公告)日：2006-05-11
申请号：US10514583
申请日：2003-05-15
申请人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
发明人： Christian Bergaud , Matthieu Guirardel , Pascal Belaubre , Benoit Belier , Jean-Bernard Pourciel
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/12 , B01L2300/0627 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , Y10T29/49996
摘要： The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device consists of at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.
摘要翻译： 本发明涉及用于主动控制生物溶液微滴沉积的装置。 本发明的装置包括至少一个平的硅杆，其包括中心体和形成点的端部区域，设置在所述点上的缝隙或凹槽。 本发明的特征在于它还包括至少一个金属轨道，其设置在中心体的一个面上并且至少部分地沿着所述狭缝或凹槽延伸。 本发明还涉及一种制造本发明的装置的方法以及使用所述装置主动控制的生物溶液微滴沉积和取样的方法。
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