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    MICROFLUIDIC DEVICE FOR PRODUCTION AND COLLECTION OF DROPLETS OF A FLUID
    1.
    发明申请
    MICROFLUIDIC DEVICE FOR PRODUCTION AND COLLECTION OF DROPLETS OF A FLUID 审中-公开
    用于生产和收集流体液滴的微流体装置

    公开(公告)号：US20130236901A1

    公开(公告)日：2013-09-12

    申请号：US13876960

    申请日：2011-10-03

    申请人： Marie-Claude Potier ,  Patrick Tabeling ,  Luce Dauphinot ,  Nadege Bois ,  Fabrice Monti ,  Pascaline Mary

    发明人： Marie-Claude Potier ,  Patrick Tabeling ,  Luce Dauphinot ,  Nadege Bois ,  Fabrice Monti ,  Pascaline Mary

    IPC分类号： C12Q1/68

    摘要： A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.

    摘要翻译： 一种用于产生和收集第一流体的单液滴的微流体装置和方法，该装置包括具有至少液滴微通道的微流体平台，其中产生分散在与第一流体不混溶的第二流体中的第一流体的单液滴流 所述液滴微通道具有至少一个入口末端和用于分配液滴流的至少一个出口末端，所述装置还包括：收集装置，其包括适于收集液滴中的至少一个的多个接收区域，用于改变 微流体平台的收集装置和出口的相对位置，用于控制液滴流动的元件和用于使液滴微通道出口处的液滴流动同步的元件以及收集装置相对于液滴微通道的相对运动 微流体平台。

    COMPOSITION AND METHOD FOR TREATING COGNITIVE IMPAIRMENTS IN DOWN SYNDROM SUBJECTS
    2.
    发明申请
    COMPOSITION AND METHOD FOR TREATING COGNITIVE IMPAIRMENTS IN DOWN SYNDROM SUBJECTS 有权
    用于治疗下行综合征患者的认知障碍的组合物和方法

    公开(公告)号：US20120283248A1

    公开(公告)日：2012-11-08

    申请号：US13392044

    申请日：2010-08-24

    申请人： Marie-Claude Potier ,  Robert Dodd ,  Benoît Delatour ,  Jérôme Braudeau ,  Yann Herault

    发明人： Marie-Claude Potier ,  Robert Dodd ,  Benoît Delatour ,  Jérôme Braudeau ,  Yann Herault

    IPC分类号： A61K31/551 ,  C07D417/04 ,  A61P25/28 ,  A61K31/5025 ,  A61K31/427 ,  C07D487/04 ,  C07D487/14

    CPC分类号： A61K31/381 ,  A61K9/0019 ,  A61K31/4162 ,  A61K31/502 ,  A61K31/5517

    摘要： Compounds having inverse agonist functional selectivity for GABAA receptors containing the α5 subunit for use as a medicament in the treatment of cognitive impairments in subjects suffering from Down syndrome. The use of these compounds is disclosed. Pharmaceutical compositions for such treatment can comprise these compounds or suitable pharmaceutically acceptable salt thereof, a polyethoxylated castor oil and dimethyl sulfoxide (DMSO). Methods are disclosed for enhancing cognitive function, or treating or lessening the severity of cognitive impairments, in subjects suffering from Down syndrome by administering to a subject in need thereof a pharmaceutically effective amount of one or more of these compounds.

    摘要翻译： 对于含有α5亚基的GABA A受体具有反向激动剂功能选择性的化合物用作治疗患有唐氏综合症的受试者的认知障碍的药物。 公开了这些化合物的用途。 用于这种治疗的药物组合物可以包含这些化合物或其合适的药学上可接受的盐，聚乙氧基化蓖麻油和二甲基亚砜（DMSO）。 公开了通过向有需要的受试者施用药学有效量的一种或多种这些化合物来公开用于增强认知功能或治疗或减轻认知障碍的严重性的方法。

    Apparatus for parallel detection of the behaviour of mechanical micro-oscillators
    3.
    发明授权
    Apparatus for parallel detection of the behaviour of mechanical micro-oscillators 失效
    用于并行检测机械微振荡器行为的装置

    公开(公告)号：US07173714B2

    公开(公告)日：2007-02-06

    申请号：US10415984

    申请日：2001-11-05

    申请人： Jean-Paul Roger ,  Albert Claude Boccara ,  Christian Bergaud ,  Marie-Claude Potier

    发明人： Jean-Paul Roger ,  Albert Claude Boccara ,  Christian Bergaud ,  Marie-Claude Potier

    IPC分类号： G01B9/02

    CPC分类号： G02B21/00 ,  B82Y35/00 ,  G01N29/036 ,  G01N2291/0256

    摘要： The invention concerns an apparatus for parallel detection of the behaviour of mechanical micro-oscillators interacting with the sample (21). The amplitude and the phase of resonance of micro-oscillators (12) are measured with optical means. The invention is characterised in that a source (1) is active during a fraction 1/n of the period (n being an integer) and of variable phase p/n of the period (p being an integer). Interferences are produced between light beams generated by reflection of incident light beams (7) and (8) on the micro-oscillators (12). Periodically the micro-oscillators (12) are displaced by means. The value of the parameter p (p being an integer) is varied and N elementary measurements are integrated to obtain a measurement representing each of the values of p. The phase and amplitude of each micro-oscillator (12) are calculated on the basis of the representative data obtained for each value of p and this for a large number of accumulations. The invention is applicable in the field of nanotechnologies.

    摘要翻译： 本发明涉及用于并行检测与样品（21）相互作用的机械微振荡器的行为的装置。 用光学方法测量微振荡器（12）的振幅和相位。 本发明的特征在于，在周期（n为整数）的分数1 / n和周期的可变相位p / n（p为整数）的数量级中，源（1）是有效的。 在微振荡器（12）上的入射光束（7）和（8）的反射产生的光束之间产生干扰。 定期地，微振荡器（12）通过装置移位。 参数p（p是整数）的值是变化的，并且积分N个基本测量值以获得表示p的每个值的测量值。 每个微振荡器（12）的相位和振幅都是根据为每个p值获得的代表性数据计算出来的，而且这对于大量的累加来计算。 本发明适用于纳米技术领域。