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    Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions
    2.
    发明授权
    Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions 有权
    在皮肤病学组合物中使用亲水性渗透剂来治疗甲真菌病以及相应的组合物

    公开(公告)号：US06455592B1

    公开(公告)日：2002-09-24

    申请号：US09678772

    申请日：2000-10-04

    申请人： Jean-Pierre Laugier ,  Marie-France Rude ,  Philippe Touzan ,  François Rigenbach

    发明人： Jean-Pierre Laugier ,  Marie-France Rude ,  Philippe Touzan ,  François Rigenbach

    IPC分类号： A61K31135

    CPC分类号： A61Q3/00 ,  A61K8/33 ,  A61K8/41 ,  A61K9/0014 ,  A61K31/135 ,  A61K31/137 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  Y10S514/858 ,  Y10S514/947

    摘要： The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C8-C10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

    摘要翻译： 通常用于经皮穿透活性成分的亲水性渗透剂令人惊奇地发现通过指甲改善抗真菌剂的渗透性。 相应的皮肤病学组合物含有至少一种抗真菌剂，特别是选自烯丙胺族的那些，例如特比萘芬-HCl和naftifine-HCl; 选自二醇，二醇单醚，二醇二醚，二甲基亚砜，己内酰胺，二甲基异山梨醇，异丙基甘油，二甲基咪唑啉酮，乳酸乙酯，聚氧乙烯化C8-C10甘油酯，聚乙二醇20月桂酸甘油酯和二甲基乙酰胺的至少一种亲水性渗透剂 ; 和溶解所述抗真菌剂并且其中所述渗透剂至少部分可混溶的所述渗透剂的水 - 醇溶剂介质。