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    Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion
    1.
    发明授权
    Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion 有权
    用两亲性硫醚涂覆疏水表面以减少蛋白质吸附和细胞粘附

    公开(公告)号：US07427410B2

    公开(公告)日：2008-09-23

    申请号：US10246362

    申请日：2002-09-18

    申请人： Jeffrey A. Hubbell ,  Jane P. Bearinger ,  Alessandro Napoli ,  Marcus Textor ,  Nicola Tirelli

    发明人： Jeffrey A. Hubbell ,  Jane P. Bearinger ,  Alessandro Napoli ,  Marcus Textor ,  Nicola Tirelli

    IPC分类号： A61F2/00 ,  A61K38/43 ,  C12N11/08

    CPC分类号： A61L27/34 ,  C08L81/02

    摘要： The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spacing or length of pendant chains or hydrophilic blocks in an amphiphilic thioether. Techniques for determining spacing include adsorbing the thioether from a solution or a colloidal suspension, or controlling the degree of polymerization of the thioether. Techniques for controlling the length of the pendant chains include controlling the degree of polymerization of the pendant chains. Multiblock copolymers of poly(propylene sulfide) and poly(ethylene glycol) (“PPS-PEG”) represent an exemplary family of amphiphilic thioethers. Methods for coating surfaces with amphiphilic thioethers are also provided.

    摘要翻译： 本发明提供了用特别设计的硫醚和两亲性硫醚涂覆表面的方法和设备，其减少蛋白质吸附和/或细胞粘附。 该还原可以通过例如通过控制两亲性硫醚中的侧链或亲水嵌段的间隔或长度来实现。 用于确定间隔的技术包括从溶液或胶体悬浮液中吸附硫醚，或控制硫醚的聚合度。 用于控制侧链长度的技术包括控制侧链的聚合度。 聚（丙烯硫醚）和聚（乙二醇）（“PPS-PEG”）的多嵌段共聚物代表两亲性硫醚的典型族。 还提供了用两亲硫醚涂覆表面的方法。