公开(公告)号：US08034395B2

公开(公告)日：2011-10-11

申请号：US12662932

申请日：2010-05-12

申请人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

发明人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

IPC分类号： G01N1/28 ,  G02B6/00

CPC分类号： C23F11/1676 ,  A61B5/14546 ,  A61B5/415 ,  A61B17/68 ,  A61F2/30767 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00215 ,  A61F2310/00227 ,  A61F2310/00239 ,  A61F2310/00251 ,  A61F2310/00281 ,  A61F2310/00317 ,  A61F2310/00323 ,  A61F2310/0061 ,  A61F2310/00616 ,  A61F2310/00634 ,  A61F2310/0064 ,  A61F2310/00646 ,  A61F2310/00652 ,  A61F2310/00658 ,  A61F2310/00664 ,  A61F2310/00742 ,  A61F2310/00748 ,  A61F2310/00766 ,  A61F2310/00772 ,  A61F2310/00778 ,  A61F2310/00784 ,  A61F2310/00874 ,  A61F2310/0088 ,  A61F2310/00892 ,  A61F2310/00898 ,  A61F2310/00904 ,  A61F2310/0091 ,  A61F2310/00976 ,  A61L27/34 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C04B41/009 ,  C04B41/4994 ,  C04B41/84 ,  C04B2111/00836 ,  Y10T428/31678 ,  C04B35/01

摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2   (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2   (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.

摘要翻译： 本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。 根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。 本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。

公开(公告)号：US07740896B2

公开(公告)日：2010-06-22

申请号：US12230915

申请日：2008-09-08

申请人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

发明人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

IPC分类号： G01N1/28 ,  G02B6/00

CPC分类号： C23F11/1676 ,  A61B5/14546 ,  A61B5/415 ,  A61B17/68 ,  A61F2/30767 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00215 ,  A61F2310/00227 ,  A61F2310/00239 ,  A61F2310/00251 ,  A61F2310/00281 ,  A61F2310/00317 ,  A61F2310/00323 ,  A61F2310/0061 ,  A61F2310/00616 ,  A61F2310/00634 ,  A61F2310/0064 ,  A61F2310/00646 ,  A61F2310/00652 ,  A61F2310/00658 ,  A61F2310/00664 ,  A61F2310/00742 ,  A61F2310/00748 ,  A61F2310/00766 ,  A61F2310/00772 ,  A61F2310/00778 ,  A61F2310/00784 ,  A61F2310/00874 ,  A61F2310/0088 ,  A61F2310/00892 ,  A61F2310/00898 ,  A61F2310/00904 ,  A61F2310/0091 ,  A61F2310/00976 ,  A61L27/34 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C04B41/009 ,  C04B41/4994 ,  C04B41/84 ,  C04B2111/00836 ,  Y10T428/31678 ,  C04B35/01

摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2  (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2  (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

公开(公告)号：US20090093610A1

公开(公告)日：2009-04-09

申请号：US12064564

申请日：2005-08-24

申请人： Marcus Textor ,  Stefan Zurcher ,  Karl Gademann ,  Samuele Tosatti

发明人： Marcus Textor ,  Stefan Zurcher ,  Karl Gademann ,  Samuele Tosatti

IPC分类号： C08G73/06

CPC分类号： C08G65/3315 ,  A61K47/60 ,  C08G65/329 ,  Y10T428/265 ,  Y10T428/31511 ,  Y10T428/31663 ,  Y10T428/31725 ,  Y10T428/31855

摘要： Described are compounds that are capable of forming adlayers, the compounds comprising at least one headgroup A, an optional linker B, a polymer C, a terminal group D and an optional crosslinking group R, wherein the headgroup A is a compound of the following formula wherein X is independently selected from an acidic group, Y is a group derived from a convenient coupling group, Z1, Z3, and Z4 are C or N+ Z2, Z5 and Z6 are C-L1 or N+-L, wherein L1 is H or an electron withdrawing group, L is C1-C6 alkyl, in particular C1-C4 alkyl L2 and L3 are independently selected from H or C1-C6 alkyl, or L2 may form together with L1 or L of Z6 a heterocycle, in particular a positively charged heterocycle, n is 0, or 1, or 2, or 3, m is 0 or 1.

摘要翻译： 描述的是能够形成附着物的化合物，所述化合物包含至少一个头基A，任选的接头B，聚合物C，末端基团D和任选的交联基团R，其中头基A是下式的化合物 其中X独立地选自酸性基团，Y是衍生自方便偶合基团的基团，Z 1，Z 3和Z 4是C或N + Z 2，Z 5和Z 6是C-L 1或N + -L，其中L 1是H或 吸电子基团，L是C1-C6烷基，特别是C1-C4烷基L2和L3独立地选自H或C1-C6烷基，或L2可以与Z6的L1或L一起形成杂环，特别是正 带电杂环，n为0或1，或2或3，m为0或1。

公开(公告)号：US06884628B2

公开(公告)日：2005-04-26

申请号：US09560472

申请日：2000-04-28

申请人： Jeffrey A. Hubbell ,  Marcus Textor ,  Donald L. Elbert ,  Stephanie Finken ,  Rolf Hofer ,  Nicholas D. Spencer ,  Laurence Ruiz-Taylor

发明人： Jeffrey A. Hubbell ,  Marcus Textor ,  Donald L. Elbert ,  Stephanie Finken ,  Rolf Hofer ,  Nicholas D. Spencer ,  Laurence Ruiz-Taylor

IPC分类号： A61L27/34 ,  A61L31/10 ,  G01N33/543 ,  G01N33/551 ,  G01N33/53

CPC分类号： B82Y30/00 ,  A61B5/14546 ,  A61B5/1459 ,  A61L27/34 ,  A61L31/10 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/551 ,  Y10S435/815 ,  Y10S435/961 ,  Y10S435/969 ,  Y10S436/819 ,  Y10S436/823

摘要： Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.

摘要翻译： 具有分子结构和针对特定应用优化的性能的多功能聚异戊二烯共聚物在/或应用于基材表面进行合成，用于分析和感测目的。 涂层对于抑制分析物溶液中存在的分子或离子组分的非特异性相互作用，吸附或附着是特别有用的。 能够识别，相互作用并且特异性结合含有待检测分析物的物质中的靶分子的化学，生物化学或生物学基团可与多功能共聚物偶联，整合或吸收。 这些多功能共聚物涂层与各种不同的已知方法兼容，以检测，感测和定量分析物中的目标分子。 多功能共聚物涂层通常包括基于聚阳离子或聚阴离子（共同称为“聚阴离子”）骨架的刷共聚物，侧链具有控制与环境相互作用的侧链，例如聚（乙二醇）或聚（环氧乙烷） 减少细胞粘附的侧链和分析物特异性侧链。 它们可用于通过已知技术如微流体或接触印刷技术的应用将表面图案化成非粘合性和特异性粘合剂区域。

公开(公告)号：US20080113352A1

公开(公告)日：2008-05-15

申请号：US11663310

申请日：2005-09-20

申请人： Janos Voros ,  Marcus Textor ,  Clarence Tang ,  Beat Keller

发明人： Janos Voros ,  Marcus Textor ,  Clarence Tang ,  Beat Keller

IPC分类号： C12Q1/68 ,  H01L21/00 ,  C12M1/34

CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00495 ,  B01J2219/00531 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00635 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074

摘要： Described is a method for electrochemically patterning a microelectrode array (MEA) with at least two different kinds of macromolecules. Said method comprising the steps of: providing a platform with a surface that comprises individually addressable conductive microelectrode surfaces; covering said platform surface with an adlayer of resistant polymer; desorbing said adlayer from a first kind of conductive microelectrodes intended for the selective adsorption of a first kind of macromolecules, in particular proteins, by applying a potential; subjecting the desorbed surfaces to the first macromolecule under conditions such that said first macromolecule adsorbs to said desorbed surfaces, and repeating the desorption/adsorption steps with a second or further kind of macromolecules until all kinds of desired macromolecules are adsorbed. A microchip array produced by the inventive method is also described. Such chip arrays can be used to study a large diversity of biological interactions, e.g. protein-protein interactions, protein-cell interactions, protein-nucleic acid interactions, etc.

摘要翻译： 描述了用至少两种不同种类的大分子电化学构图微电极阵列（MEA）的方法。 所述方法包括以下步骤：提供具有包括单独可寻址的导电微电极表面的表面的平台; 用抗性聚合物的覆层覆盖所述平台表面; 从用于通过施加电位选择性吸附第一种大分子，特别是蛋白质的第一种导电微电极解吸附子; 在使所述第一高分子吸附到所述解吸附表面的条件下将解吸附的表面经受脱附的表面，并且用第二种或其它类型的大分子重复解吸附/吸附步骤，直到吸附所有种类的所需大分子。 还描述了通过本发明方法制造的微芯片阵列。 这种芯片阵列可用于研究大量生物相互作用，例如， 蛋白质 - 蛋白质相互作用，蛋白质 - 细胞相互作用，蛋白质 - 核酸相互作用等。

公开(公告)号：US07091127B2

公开(公告)日：2006-08-15

申请号：US10246500

申请日：2002-09-18

申请人： Jeffrey A. Hubbell ,  Jane P. Bearinger ,  Marcus Textor

发明人： Jeffrey A. Hubbell ,  Jane P. Bearinger ,  Marcus Textor

IPC分类号： H01L21/302

CPC分类号： B29C43/003 ,  B29C2043/025 ,  B41M3/006 ,  C23F1/02 ,  G01Q80/00 ,  G03F7/0002 ,  H01L51/0015 ,  H01L51/0021

摘要： The present invention provides methods and apparatus for locally patterning surfaces. In one such method, an oxidizable thioether is adsorbed onto a conductive surface. The surface is then contacted with a fluid medium. A conducting stamp is then brought into contact with the fluid medium above the thioether-coated surface. Next, a potential is applied between the stamp and the surface. It is expected that the charge will be transferred through the medium to the coated surface along a shortest distance path, thereby locally oxidizing the thioether and effectively creating a negative patterned image of the conducting stamp on the surface. Remaining adsorbed thioether may then be used as a mask for standard etching or material addition procedures.

公开(公告)号：US20050014151A1

公开(公告)日：2005-01-20

申请号：US10489688

申请日：2001-09-12

申请人： Marcus Textor ,  Roger MIchel ,  Janos Voros ,  Jeffrey Hubbell ,  Jost Lussi

发明人： Marcus Textor ,  Roger MIchel ,  Janos Voros ,  Jeffrey Hubbell ,  Jost Lussi

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  G01N33/543 ,  C12Q1/68 ,  C12M1/34

CPC分类号： B82Y30/00 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B82Y15/00 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/54373 ,  C08L71/02

摘要： A device with chemical surface patterns (defined surface areas of at least two different chemical compositions) with biochemical or biological relevance on substrates with prefabricated patterns of at least two different types of regions (α, β, . . . ), whereas at least two different, consecutively applied molecular self-assembly systems (A, B, . . . ) are used in a way that at least one of the applied assembly systems (A or B or . . . ) is specific to one type of the prefabricated patterns (α or β or . . . ).

摘要翻译： 具有至少两种不同类型区域（α，β，...）的预制图案的具有生化或生物相关性的具有化学表面图案（至少两种不同化学组成的限定表面积）的装置，而至少两种 使用不同的连续应用的分子自组装系统（A，B ...），其方法是至少一个所应用的组装系统（A或B或...）特定于一种类型的预制模式 （alpha或beta或...）。

公开(公告)号：US5527572A

公开(公告)日：1996-06-18

申请号：US420858

申请日：1995-04-12

申请人： Marcus Textor ,  Roman Fuchs ,  Volkmar Gillich ,  Erich Simon

发明人： Marcus Textor ,  Roman Fuchs ,  Volkmar Gillich ,  Erich Simon

IPC分类号： B21B3/00 ,  C22C21/12 ,  C22F1/04 ,  C23C14/00 ,  C23C14/02 ,  C23C14/06 ,  C23C16/00 ,  C23C16/02 ,  G02B1/10 ,  G02B5/08

CPC分类号： C23C16/0254 ,  C22F1/04 ,  C23C14/021 ,  C23C14/028 ,  G02B1/105 ,  G02B5/0808 ,  G02B5/0858 ,  Y10T428/24975 ,  Y10T428/265 ,  Y10T428/31678

摘要： Articles of aluminum containing at least one unanodized surface or parts of at least one unanodized surface which are suitable for the deposition of layers or layer systems from the gas phase on said unanodized surfaces, the unanodized surfaces being of a refined aluminum with a degree of purity of equal to, or greater than, 98.3% by weight or aluminum alloys of said aluminum with at least one of the elements from the series comprising Si, Mg, Mn, Cu, Zn or Fe, and the surfaces have a peak-to-valley height Ra of equal to, or less than, 1 .mu.m, and the layer or the layer system is a reflective layer, in particular for radiations in the optical range.

公开(公告)号：US4425411A

公开(公告)日：1984-01-10

申请号：US376415

申请日：1982-05-10

申请人： Marcus Textor ,  Tibor Kugler ,  Jean-Pierre Gabathuler

发明人： Marcus Textor ,  Tibor Kugler ,  Jean-Pierre Gabathuler

IPC分类号： B22D17/22 ,  B22C3/00 ,  B22C23/02 ,  B22D17/00 ,  B22D13/10

CPC分类号： B22C23/02 ,  B22C3/00

摘要： The mold features on its work face a thermally insulating protective layer of sub-micron metal oxide particles.The coating can be applied by spraying an aqueous sol of a metal oxide onto the mold work face which has been heated to at least 60.degree. C.The use of sub-micron sized metal oxide particles enables the formation of a protective coating of very low density and consequently very low thermal conductivity. The coating can furthermore be deposited very economically, and likewise removed again.

摘要翻译： 模具的特征在于工作面上是亚微米金属氧化物颗粒的隔热保护层。 可以通过将金属氧化物的水性溶胶喷涂到已经被加热到至少60℃的模具加工面上来施加涂层。使用亚微米尺寸的金属氧化物颗粒使得形成非常低的保护涂层 密度，因此非常低的热导率。 此外，涂层可以非常经济地沉积，并且同样被再次去除。

公开(公告)号：US20100280601A1

公开(公告)日：2010-11-04

申请号：US12662932

申请日：2010-05-12

申请人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

发明人： Rolf Hofer ,  Michael Pawlak ,  Marcus Textor ,  Eveline Schürmann-Mader ,  Markus Ehrat ,  Samuele Tosatti

IPC分类号： A61L27/10 ,  A61L31/16 ,  A61L27/54 ,  A61L29/16 ,  B32B18/00 ,  B32B15/04 ,  B32B9/04 ,  C40B40/00 ,  A61C8/00 ,  A61F2/38 ,  A61F2/32 ,  A61F2/30 ,  A61F2/44 ,  A61N1/36 ,  A61L29/02 ,  A61M25/10 ,  A61L31/02

CPC分类号： C23F11/1676 ,  A61B5/14546 ,  A61B5/415 ,  A61B17/68 ,  A61F2/30767 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00215 ,  A61F2310/00227 ,  A61F2310/00239 ,  A61F2310/00251 ,  A61F2310/00281 ,  A61F2310/00317 ,  A61F2310/00323 ,  A61F2310/0061 ,  A61F2310/00616 ,  A61F2310/00634 ,  A61F2310/0064 ,  A61F2310/00646 ,  A61F2310/00652 ,  A61F2310/00658 ,  A61F2310/00664 ,  A61F2310/00742 ,  A61F2310/00748 ,  A61F2310/00766 ,  A61F2310/00772 ,  A61F2310/00778 ,  A61F2310/00784 ,  A61F2310/00874 ,  A61F2310/0088 ,  A61F2310/00892 ,  A61F2310/00898 ,  A61F2310/00904 ,  A61F2310/0091 ,  A61F2310/00976 ,  A61L27/34 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C04B41/009 ,  C04B41/4994 ,  C04B41/84 ,  C04B2111/00836 ,  Y10T428/31678 ,  C04B35/01

摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2   (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2   (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.

摘要翻译： 本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。 根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。 本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。