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公开(公告)号：US5995208A
公开(公告)日：1999-11-30
申请号：US86789
申请日：1998-05-28
申请人： Jeffrey A. Sarge , Scott T. Tsuchitani , Harlow B. Christianson , Gerald G. Vurek , John M. Sperinde , Darrell H. Ogi
发明人： Jeffrey A. Sarge , Scott T. Tsuchitani , Harlow B. Christianson , Gerald G. Vurek , John M. Sperinde , Darrell H. Ogi
CPC分类号： A61B5/1459
摘要： Apparatus and a method for monitoring a percentage of the oxygen saturation in the hemoglobin of blood flowing through a blood vessel. An optical sensor that detects the percentage oxygen saturation in blood is disposed proximate a proximal end of the catheter. A thermistor is disposed adjacent to the distal end of the catheter and it is employed to detect changes in blood temperature that indicate the position of the catheter's distal end in the blood vessel. Indicia or marks visible at intervals on the outer surface of the catheter enable a medical practitioner to determine the length of the catheter that has been introduced into the blood vessel. A strain relief that is flexible and resists stretching extends along the length of the catheter. For flushing the distal end of the catheter, a fluid supply may be connected to a lumen running through the catheter to provide the flushing fluid. A removable guide wire is inserted in the lumen when positioning the distal end of the catheter at a location in the blood vessel and provides enhanced rigidity for this purpose. The catheter may be coated with an anticoagulant such as heparin, to prevent blood from coagulating on the exterior surface of the catheter.
摘要翻译： 用于监测流过血管的血液的血红蛋白中的氧饱和度百分比的装置和方法。 检测血液中氧饱和度百分比的光学传感器设置在导管近端附近。 热敏电阻设置在导管的远端附近，并且用于检测指示导管远端在血管中的位置的血液温度变化。 在导管的外表面上以间隔可见的标记或标记使医生能够确定已经被导入血管的导管的长度。 柔韧且抗拉伸的应变消除部沿着导管的长度延伸。 为了冲洗导管的远端，流体供应可以连接到穿过导管的内腔，以提供冲洗液。 当将导管的远端定位在血管中的位置时，将可移除的导丝线插入内腔，并为此提供增强的刚性。 导管可以用抗凝血剂如肝素涂覆，以防止血液凝结在导管的外表面上。
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2.发明授权User-restricted passage in reusable portion of device for monitoring a physiological pressure 失效在用于监测生理压力的装置的可重复使用部分中的用户限制通道
公开(公告)号：US5551300A
公开(公告)日：1996-09-03
申请号：US574206
申请日：1995-12-18
IPC分类号： A61B5/0215 , G01L7/00 , A61B5/02
CPC分类号： A61B5/0215
摘要： A pressure monitoring apparatus for use in monitoring a physiological fluid pressure in successive patients. Three embodiments of the pressure monitoring apparatus (10, 100, 200) are disclosed, each of which include a disposable portion ( 12, 12', 12") and a reusable portion ( 14, 14', 14"). Fluid flows through the disposable portion and into a cavity (48) that is covered with an elastomeric membrane (46, 46'). When the disposable portion is engaged with the reusable portion, the elastomeric membrane is in contact with a corresponding elastomeric membrane (50, 50'), which covers a pressure sensing cavity (52). A pressure transducer (56) is mounted in the pressure sensing cavity, and the pressure sensing cavity is filled with a fluid and is in fluid communication with a reservoir(38) when not engaged with the disposable portion. When the disposable portion is brought into engagement with the reusable portion, a passage (54, 53) connecting the reservoir with the pressure sensing cavity is blocked, thereby minimizing the volume of fluid within the pressure sensing cavity. In this way, the compliance of the pressure sensing portion is reduced, so that its frequency response is increased. In one embodiment of the pressure monitoring apparatus (100), a slider (110) is provided for covering the elastomeric membrane used on the disposable portion so that exposure of the elastomeric membrane to a fluid pressurized to a level in excess of the rated pressure for the membrane does not damage the membrane.
摘要翻译： 一种压力监测装置，用于监测连续患者的生理液压。 公开了压力监视装置（10,100,200）的三个实施例，每个实施例包括一次性部分（12,12'，12“）和可重复使用部分（14,14'，14”）。 流体流过一次性部分并进入被弹性膜（46,46'）覆盖的空腔（48）中。 当一次性部分与可重复使用部分接合时，弹性膜与相应的弹性体膜（50,50'）接触，弹性膜覆盖压力感应腔（52）。 压力传感器（56）安装在压力感测腔中，并且压力感测腔充满流体，并且当不与一次性部分接合时与压力传感器（38）流体连通。 当一次性部分与可重复使用部分接合时，将储存器与压力感测腔连接的通道（54,53）被阻挡，从而使压力感测腔内的流体体积最小化。 以这种方式，减小了压力感测部分的顺应性，使得其频率响应增加。 在压力监测装置（100）的一个实施例中，提供滑动件（110），用于覆盖在一次性部分上使用的弹性体膜，使得将弹性体膜暴露于加压到超过额定压力的水平 膜不会损坏膜。
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公开(公告)号：US07082843B2
公开(公告)日：2006-08-01
申请号：US11205929
申请日：2005-08-17
IPC分类号： G01F1/22
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.
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公开(公告)号：US06964204B2
公开(公告)日：2005-11-15
申请号：US10978866
申请日：2004-10-29
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.
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公开(公告)号：US06813964B1
公开(公告)日：2004-11-09
申请号：US10442575
申请日：2003-05-21
IPC分类号： G01F137
CPC分类号： G01F1/383 , A61M5/16813 , A61M5/16854 , A61M5/16886 , G01F1/363 , G01F1/40
摘要： The invention is directed to a device for obtaining flow rate measurements including a sensor assembly and a housing. The sensor assembly includes a body defining a first fluid flow passage having an inlet, an outlet, a flow restricting element in the first fluid flow passage between the inlet and the outlet, an upstream fluid pressure sensor, a downstream fluid pressure sensor, an upstream signal contact connected to the upstream fluid pressure sensor, and a downstream signal contact connected to the downstream fluid pressure sensor. The housing has an upstream portion defining an upstream port, a downstream portion defining a downstream port, and a probe access port configured to provide access of a probe to at least one of the upstream signal contact and downstream signal contact. The housing can also define a second fluid flow passage in parallel with the first fluid flow passage. The device can be disposable.
摘要翻译： 本发明涉及一种用于获得包括传感器组件和壳体的流量测量的装置。 传感器组件包括主体，其限定第一流体流动通道，该第一流体流动通道在入口和出口之间的第一流体流动通道中具有入口，出口，流动限制元件，上游流体压力传感器，下游流体压力传感器，上游 连接到上游流体压力传感器的信号触点和连接到下游流体压力传感器的下游信号触点。 壳体具有限定上游端口的上游部分，限定下游端口的下游部分和被配置为提供探头到达上游信号接触和下游信号接触中的至少一个的探测器访问端口。 壳体还可以限定与第一流体流动通道平行的第二流体流动通道。 该设备可以是一次性的。
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公开(公告)号：US07201846B2
公开(公告)日：2007-04-10
申请号：US10763549
申请日：2004-01-23
CPC分类号： B01D67/0088 , A61L2/022 , B01D61/18 , B01D63/087 , B01D67/003 , B01D69/02 , B01D71/027 , B01D2325/48
摘要： An anti-microbial filter (105) for a micro-fluidic system (100) includes a silicon-based filter membrane (213) having holes (218) formed therein. The membrane (213) is formed on a substrate (211). One side of the filter membrane (213) has an anti-microbial coating (216) between the holes (218) on the filter membrane (213) and the other side can include filter supports formed from a silicon substrate. A method for making the anti-microbial filter (105) includes forming a filter membrane (213) on a substrate (211), forming holes (218) in the membrane (213) by providing a filter mask (215) and etching holes (218) through holes (222) in the mask (215). Then portions of the substrate (211) are removed from the filter membrane (213) using a masking and etching process to expose the holes (218). An anti-microbial coating is applied to the membrane (213) adjacent the holes (218).
摘要翻译： 用于微流体系统（100）的抗微生物过滤器（105）包括其中形成有孔（218）的硅基过滤膜（213）。 膜（213）形成在基板（211）上。 过滤膜（213）的一侧在过滤膜（213）上的孔（218）之间具有抗微生物涂层（216），另一侧可以包括由硅衬底形成的过滤器支架。 制造抗微生物过滤器（105）的方法包括在基板（211）上形成过滤膜（213），通过提供过滤器掩模（215）和蚀刻孔（213）在膜（213）中形成孔（218） 218）通孔（222）。 然后使用掩模和蚀刻工艺从过滤膜（213）中除去衬底（211）的一部分以露出孔（218）。 将抗微生物涂层施加到邻近孔（218）的膜（213）上。
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公开(公告)号：US06349740B1
公开(公告)日：2002-02-26
申请号：US09288762
申请日：1999-04-08
IPC分类号： F16K3102
CPC分类号： A61M5/14276 , A61M5/16877 , A61M5/365 , A61M2205/0244 , A61M2205/3523 , Y10T137/2082 , Y10T137/2191 , Y10T137/7761
摘要： A monolithic flow controller for controlling the rate at which a medicinal liquid is administered to a patient. The monolithic flow controller includes one or more virtual valves that, because of their relatively small opening size (less than 0.5 &mgr;m in diameter), only permit fluid to flow through the valve when a forward bias voltage is applied. If a reverse bias voltage or no voltage is applied, fluid flow through the opening is inhibited. The fluid rate through the device is monitored using two pressure sensors or a differential pressure sensor that determine the differential pressure along the flow path through the device or relative to the external ambient pressure. The flow through the device is equal to the product of the differential pressure and the conductance of the channel in the flow controller. A capacitive bubble sensor is optionally provided to detect bubbles in the medicinal liquid being administered to the patient. The flow controller can be made sufficiently small to be injected into a patient's cardiovascular system or other portion of the patient's body through a hypodermic syringe and needle, or it can be implanted in the patient's body at a desired site. The medicinal liquid can be contained within an integral pressurized fluid reservoir, administered by gravity feed, or conveyed by a pump to an inlet port of the flow controller.
摘要翻译： 一种用于控制向患者施用药液的速率的单片流量控制器。 单片流量控制器包括一个或多个虚拟阀，由于其相对小的开口尺寸（直径小于0.5um），仅当施加正向偏置电压时，允许流体流过阀。 如果施加反向偏置电压或没有施加电压，则流过开口的流体被阻止。 使用两个压力传感器或差压传感器监测通过装置的流体速率，该压力传感器或差压传感器确定沿着穿过装置的流动路径或相对于外部环境压力的压力差。 通过该装置的流量等于流量控制器中通道的差压和电导的乘积。 可选地提供电容式气泡传感器以检测施用于患者的药液中的气泡。 流量控制器可以制造得足够小以通过皮下注射器和针头注射到患者的心血管系统或患者身体的其他部分，或者可以将其植入患者的身体所需位置。 医药液体可以容纳在通过重力进料施加的整体加压流体储存器中，或者通过泵输送到流量控制器的入口端口。
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