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公开(公告)号：US20130295011A1
公开(公告)日：2013-11-07
申请号：US13810434
申请日：2011-07-18
申请人： Christopher Paul Guise , David Francis Ackerley , Amir Ashoorzadeh , Janine Naomi Copp , Jack Urquhart Flanagan , Alexandra Marie Mowday , Adam Vorn Patterson , Gareth Adrian Prosser , Jeffrey Bruce Smaill , Sophie Phillipa Syddall , Elsie May Williams
发明人： Christopher Paul Guise , David Francis Ackerley , Amir Ashoorzadeh , Janine Naomi Copp , Jack Urquhart Flanagan , Alexandra Marie Mowday , Adam Vorn Patterson , Gareth Adrian Prosser , Jeffrey Bruce Smaill , Sophie Phillipa Syddall , Elsie May Williams
CPC分类号： A61K51/0495 , A61K38/44 , A61K47/556 , C12N9/0028 , C12N9/0036 , C12Q1/26 , Y02A50/473
摘要： The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: More particularly, although not exclusively, said enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
摘要翻译： 本发明一般涉及细菌硝基还原酶及其使用方法：更具体地，尽管不是唯一地，所述酶可用于非侵入性成像技术，监测治疗性细胞群体和基因定向酶前药治疗。 本发明还涉及细菌硝基还原酶在生物制剂的放射成像和/或消融中的用途以及在这些方法中使用的组合物。
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公开(公告)号：US20150299230A1
公开(公告)日：2015-10-22
申请号：US14423359
申请日：2013-08-22
申请人： Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp , Auckland University Limited , Victoria Link Limited
发明人： Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp
IPC分类号： C07F9/09 , C07C309/69 , C07D295/13 , C07C317/36 , C07D295/104
CPC分类号： C07F9/09 , C07C255/58 , C07C309/66 , C07C309/69 , C07C317/36 , C07C317/48 , C07D295/104 , C07D295/13 , C07D295/192 , C07F9/091
摘要： The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
摘要翻译： 本发明涉及用作靶向细胞毒性剂的化合物及其使用方法。 特别地，本发明涉及对人AKR1C3酶代谢基本上抗性的前药，使用所述化合物的细胞消融方法和使用所述化合物治疗癌症和其它过度增殖性病症的方法。
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公开(公告)号：US10357577B2
公开(公告)日：2019-07-23
申请号：US13810434
申请日：2011-07-18
申请人： Christopher Paul Guise , David Francis Ackerley , Amir Ashoorzadeh , Janine Naomi Copp , Jack Urquhart Flanagan , Alexandra Marie Mowday , Adam Vorn Patterson , Gareth Adrian Prosser , Jeffrey Bruce Smaill , Sophie Phillipa Syddall , Elsie May Williams
发明人： Christopher Paul Guise , David Francis Ackerley , Amir Ashoorzadeh , Janine Naomi Copp , Jack Urquhart Flanagan , Alexandra Marie Mowday , Adam Vorn Patterson , Gareth Adrian Prosser , Jeffrey Bruce Smaill , Sophie Phillipa Syddall , Elsie May Williams
摘要： The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: more particularly, although not exclusively, the enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.
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公开(公告)号：US09505791B2
公开(公告)日：2016-11-29
申请号：US14423359
申请日：2013-08-22
申请人： Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp
发明人： Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp
IPC分类号： C07F9/09 , C07C255/58 , C07C309/66 , C07C317/48 , C07D295/13 , C07D295/192 , C07C309/69 , C07C317/36 , C07D295/104
CPC分类号： C07F9/09 , C07C255/58 , C07C309/66 , C07C309/69 , C07C317/36 , C07C317/48 , C07D295/104 , C07D295/13 , C07D295/192 , C07F9/091
摘要： The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
摘要翻译： 本发明涉及用作靶向细胞毒性剂的化合物及其使用方法。 特别地，本发明涉及对人AKR1C3酶代谢基本上抗性的前药，使用所述化合物的细胞消融方法和使用所述化合物治疗癌症和其它过度增殖性病症的方法。
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