公开(公告)号：US5428078A

公开(公告)日：1995-06-27

申请号：US320101

申请日：1994-10-07

申请人： Jeffrey D. Cohen ,  Carl W. Erkenbrecher, Jr. ,  Sharon Haynie ,  Michael J. Kelley ,  Henry Kobsa ,  Arthur N. Roe ,  Michael H. Scholla

发明人： Jeffrey D. Cohen ,  Carl W. Erkenbrecher, Jr. ,  Sharon Haynie ,  Michael J. Kelley ,  Henry Kobsa ,  Arthur N. Roe ,  Michael H. Scholla

IPC分类号： A61L15/26 ,  A61L27/18 ,  A61L29/06 ,  B29C35/08 ,  B29C59/16 ,  C08J7/12 ,  A61K31/74 ,  C08J3/28

CPC分类号： C08J7/12 ,  A61L15/26 ,  A61L27/18 ,  A61L29/06 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2035/0838 ,  B29C2035/0877 ,  B29C2791/009 ,  B29K2075/00 ,  B29K2075/02 ,  B29K2077/00 ,  B29L2031/753

摘要： Polyamide, polyurea, polyhydrazide, and polyurethane materials having substantially modified surfaces which are antimicrobial are disclosed. The disclosure also relates to selective ultraviolet (UV) photon irradiation, high energy electron irradiation low energy electron irradiation for preparing such antimicrobial, polymeric materials. The disclosure further provides methods for controlling microorganisms, and products made from the antimicrobial, polymeric materials of this invention.

摘要翻译： PCT No.PCT / US90 / 06473。 371日期：1992年5月4日 102（e）日期1992年5月4日PCT 1990年11月5日PCT PCT。 公开号WO91 / 06593 日本1991年5月16日公开了具有抗菌性的基本上改性表面的聚酰胺，聚脲，聚酰肼和聚氨酯材料。 本公开还涉及选择性紫外（UV）光子照射，高能电子辐射低能电子辐射以制备这种抗微生物聚合材料。 本公开还提供了用于控制微生物的方法和由本发明的抗微生物聚合物材料制成的产品。

公开(公告)号：US20060121588A1

公开(公告)日：2006-06-08

申请号：US11282993

申请日：2006-02-13

申请人： Mark Emptage ,  Sharon Haynie ,  Lisa Laffend ,  Jeff Pucci ,  Gregory Whited

发明人： Mark Emptage ,  Sharon Haynie ,  Lisa Laffend ,  Jeff Pucci ,  Gregory Whited

IPC分类号： C12P7/18 ,  C07H21/04 ,  C12P21/06 ,  C12N9/02 ,  C12N15/74 ,  C12N1/21

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/90 ,  C12N15/52 ,  C12P7/18

摘要： The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, a dehydratase reactivation factor and a 1,3-propanediol oxidoreductase (dhaT). The dramatically improved process relies on the presence in E. coli of a gene encoding a non-specific catalytic activity sufficient to convert 3-hydroxypropionaldehyde to 1,3-propanediol.

公开(公告)号：US20060148053A1

公开(公告)日：2006-07-06

申请号：US11282497

申请日：2006-01-16

申请人： Mark Emptage ,  Sharon Haynie ,  Lisa Laffend ,  Jeff Pucci ,  Gregory Whited

发明人： Mark Emptage ,  Sharon Haynie ,  Lisa Laffend ,  Jeff Pucci ,  Gregory Whited

IPC分类号： C12P7/18 ,  C07H21/04 ,  C12P21/06 ,  C12N9/02 ,  C12N1/21 ,  C12N15/74

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/90 ,  C12N15/52 ,  C12P7/18

摘要： The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with the Klebsiella pneumoniae dha regulon genes dhaR, orfY, dhaT, orfX, orfW, dhaB1, dhaB2, dhaB3, and orfZ, all these genes arranged in the same genetic organization as found in wild type Klebsiella pneumoniae. In another aspect of the present invention, an improved process for the production of 1,3-propanediol from glucose using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, and a dehydratase reactivation factor compared to an identical process using a recombinant E. coli containing genes encoding a G3PDH, a G3P phosphatase, a dehydratase, a dehydratase reactivation factor and a 1,3-propanediol oxidoreductase (dhaT). The dramatically improved process relies on the presence in E. coli of a gene encoding a non-specific catalytic activity sufficient to convert 3-hydroxypropionaldehyde to 1,3-propanediol.