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公开(公告)号:US20150126490A1
公开(公告)日:2015-05-07
申请号:US14527328
申请日:2014-10-29
申请人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Jeff Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
发明人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Jeff Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC分类号: C07D498/04 , A61K31/497 , A61K45/06 , C07D401/04 , A61K31/4545 , C07D405/14 , A61K31/506 , C07D409/04 , A61K31/4436 , A61K31/5383 , C07D241/20 , A61K31/4965 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/553 , C07D405/04
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
摘要翻译: 本发明提供式(I)的化合物或其盐; 和这些化合物的治疗用途。 本发明还提供包含这些化合物的药物组合物,以及包含这些化合物与治疗性助剂的组合物。
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公开(公告)号:US20170182038A1
公开(公告)日:2017-06-29
申请号:US14964057
申请日:2015-12-09
申请人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
发明人: Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC分类号: A61K31/497 , A61K31/5355 , A61K31/4436 , A61K31/4433 , A61K31/44
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号:US20120225859A1
公开(公告)日:2012-09-06
申请号:US13471111
申请日:2012-05-14
申请人: Matthew BURGER , Zhi-Jie NI , Sabina PECCHI , Gordana ATALLAH , Sarah BARTULIS , Kelly FRAZIER , Aaron SMITH , Joelle VERHAGEN , Yanchen ZHANG , Allan WAGMAN , Simon NG , Keith PFISTER , Daniel POON , Alicia LOUIE , Teresa PICK , Paul BARSANTI , Edwin IWANOWICZ , Wendy FANTL , Thomas HENDRICKSON , Mark KNAPP , Hanne MERRITT , Charles VOLIVA , Marion WIESMANN , Xiaohua XIN
发明人: Matthew BURGER , Zhi-Jie NI , Sabina PECCHI , Gordana ATALLAH , Sarah BARTULIS , Kelly FRAZIER , Aaron SMITH , Joelle VERHAGEN , Yanchen ZHANG , Allan WAGMAN , Simon NG , Keith PFISTER , Daniel POON , Alicia LOUIE , Teresa PICK , Paul BARSANTI , Edwin IWANOWICZ , Wendy FANTL , Thomas HENDRICKSON , Mark KNAPP , Hanne MERRITT , Charles VOLIVA , Marion WIESMANN , Xiaohua XIN
IPC分类号: A61K31/5377 , C07D413/14 , C12N5/07 , A61K31/553 , A61K31/541 , C07D471/08 , A61P35/00 , A61K31/538
CPC分类号: C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译: 磷脂酰肌醇(PI)3-激酶抑制剂化合物(I),其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子,蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。
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