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1.发明授权Adsorption, detection and identification of components of ambient air with desorption/ionization on silicon mass spectrometry (DIOS-MS) 有权通过硅质谱法（DIOS-MS）解吸/电离的环境空气组分的吸附，检测和鉴定公开(公告)号：US07564027B2
公开(公告)日：2009-07-21
申请号：US10545332
申请日：2004-02-09
IPC分类号： H01J49/00
CPC分类号： G01N1/2214 , H01J49/0418 , H01J49/0422 , Y10T428/24802 , Y10T428/249953 , Y10T428/29 , Y10T428/2913 , Y10T436/24 , Y10T436/25
摘要： The present invention provides a device, system, and associated methods to actively or passively sample air by directing it onto the surface of a porous light-absorbing semiconductor, for example, a desorption/ionization on porous silicon (“DIOS”) chip. Upon adsorption of an analyte, the surface may be analyzed directly by laser desorption/ionization time-of-flight mass spectrometry. Because the process of laser desorption/ionization and subsequent mass detection does not require elevated temperatures, thermal degradation of analytes is avoided.
摘要翻译： 本发明提供了一种通过将空气引导到多孔光吸收半导体的表面上，例如在多孔硅（“DIOS”）芯片上的解吸/电离来主动或被动地对空气进行取样的装置，系统和相关方法。 在分析物吸附后，可以通过激光解吸/电离飞行时间质谱直接分析表面。 由于激光解吸/电离和随后的质量检测过程不需要升高的温度，因此避免了分析物的热降解。
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公开(公告)号：US07938961B2
公开(公告)日：2011-05-10
申请号：US11195232
申请日：2005-08-02
IPC分类号： B01D15/08
CPC分类号： G01N30/6078 , B01J2220/84 , G01N30/603
摘要： Disclosed herein are an apparatus and method for effectuating increased chromatographic efficiency in a capillary column by employing a retaining frit disposed within an analytical capillary. By disposing the retaining frit within the analytic capillary, the void volume is significantly minimized. The columns and methods described herein produce a simplified analytical capillary and retaining frit apparatus that provides greater chromatographic efficiency. Additionally, the column of the instant invention maintains chromatographic fidelity by reducing the transfer diameter as well as facilitating fluidic connections in situ.
摘要翻译： 本文公开了通过使用设置在分析毛细管内的保留玻璃料来实现毛细管柱中提高的色谱效率的装置和方法。 通过将保留玻璃料放置在分析毛细管内，空隙体积被显着地最小化。 本文所述的柱和方法产生简化的分析毛细管并保留玻璃料装置，其提供更高的色谱效率。 此外，本发明的色谱柱通过减少转印直径以及促进原位的流体连接来保持色谱保真度。
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3.发明申请Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms 有权用于识别液相色谱/质谱数据和形成光谱和色谱图中的峰的装置和方法公开(公告)号：US20100187414A1
公开(公告)日：2010-07-29
申请号：US12641812
申请日：2009-12-18
IPC分类号： H01J49/26
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8617 , G01N30/8689 , G06K9/00523 , H01J49/022
摘要： Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window.
摘要翻译： 通过创建光谱和色谱数据的二维数据矩阵来分析由LC / MS系统产生的色谱图和质谱。 可以通过将由LC / MS系统的质谱仪部分生成的光谱放置在数据矩阵的连续列中来创建二维矩阵。 以这种方式，数据矩阵的行对应于色谱数据，数据矩阵的列对应于光谱。 指定二维滤波器并将其应用于数据矩阵，以增强系统检测与离子相关的峰值的能力。 二维滤波器根据所需的标准进行指定。 可以指定Rank-1和2级滤波器来提高计算效率。 应用二维滤波器的一种方法是通过将数据矩阵与二维滤波器卷积以产生输出数据矩阵。 在输出数据矩阵中识别与检测到的离子相对应的峰。 峰的参数被确定并存储以用于随后的处理，包括定量或简化色谱图或光谱，例如通过鉴定与具有滞留时间落在规定的保留时间窗内或具有质荷比的离子相关联的峰 指定的质荷比窗口。
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4.发明授权Apparatus and method for identifying peaks in liquid chromatography/mass spectrometry data and for forming spectra and chromatograms 有权用于鉴定液相色谱/质谱数据中的峰并用于形成光谱和色谱图的装置和方法公开(公告)号：US08017908B2
公开(公告)日：2011-09-13
申请号：US12641812
申请日：2009-12-18
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8617 , G01N30/8689 , G06K9/00523 , H01J49/022
摘要： Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window.
摘要翻译： 通过创建光谱和色谱数据的二维数据矩阵来分析由LC / MS系统产生的色谱图和质谱。 可以通过将由LC / MS系统的质谱仪部分生成的光谱放置在数据矩阵的连续列中来创建二维矩阵。 以这种方式，数据矩阵的行对应于色谱数据，数据矩阵的列对应于光谱。 指定二维滤波器并将其应用于数据矩阵，以增强系统检测与离子相关的峰值的能力。 二维滤波器根据所需的标准进行指定。 可以指定Rank-1和2级滤波器来提高计算效率。 应用二维滤波器的一种方法是通过将数据矩阵与二维滤波器卷积以产生输出数据矩阵。 在输出数据矩阵中识别与检测到的离子相对应的峰。 峰的参数被确定并存储以用于随后的处理，包括定量或简化色谱图或光谱，例如通过鉴定与具有滞留时间落在规定的保留时间窗内或具有质荷比的离子相关联的峰 指定的质荷比窗口。
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5.发明授权Apparatus and method for identifying peaks in liquid chromatography/mass spectrometry data and for forming spectra and chromatograms 有权用于鉴定液相色谱/质谱数据中的峰并用于形成光谱和色谱图的装置和方法公开(公告)号：US07645984B2
公开(公告)日：2010-01-12
申请号：US10588967
申请日：2005-02-11
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8617 , G01N30/8689 , G06K9/00523 , H01J49/022
摘要： Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to charge ratios falling within a specified mass-to-charge ratio window.
摘要翻译： 通过创建光谱和色谱数据的二维数据矩阵来分析由LC / MS系统产生的色谱图和质谱。 可以通过将由LC / MS系统的质谱仪部分生成的光谱放置在数据矩阵的连续列中来创建二维矩阵。 以这种方式，数据矩阵的行对应于色谱数据，数据矩阵的列对应于光谱。 指定二维滤波器并将其应用于数据矩阵，以增强系统检测与离子相关的峰值的能力。 二维滤波器根据所需的标准进行指定。 可以指定Rank-1和2级滤波器来提高计算效率。 应用二维滤波器的一种方法是通过将数据矩阵与二维滤波器卷积以产生输出数据矩阵。 在输出数据矩阵中识别与检测到的离子相对应的峰。 峰的参数被确定并存储以用于随后的处理，包括定量或简化色谱或光谱，例如通过鉴定与具有落入规定保留时间窗内的保留时间的离子相关联的峰或者具有落入 指定的质荷比窗口。
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