公开(公告)号：US20230384269A1

公开(公告)日：2023-11-30

申请号：US18447604

申请日：2023-08-10

申请人： Roche Diagnostics Operations, Inc.

发明人： Peter Kupser ,  Andreas Leinenbach

IPC分类号： G01N30/16 ,  G01N30/60 ,  G01N35/00

CPC分类号： G01N30/16 ,  G01N30/6078 ,  G01N30/6047 ,  G01N35/00732 ,  G01N2030/167 ,  G01N2030/027

摘要： A column device for an automatic analyser. The automatic analyzer comprises a high performance liquid chromatography (HPLC) module. The HPLC module comprises a fixation device configured to automatically fix and release a chromatographic column. The column device comprises a column jacket and a capillary. The capillary comprises predetermined dimensions and is disposed within the column jacket. The column device is configured to be installed at the HPLC module using the fixation device. Further, an automatic analyzer is disclosed.

公开(公告)号：US20230149831A1

公开(公告)日：2023-05-18

申请号：US18154703

申请日：2023-01-13

申请人： DIONEX SOFTRON GMBH

发明人： Daniel BUERGER ,  Michael SCHADL ,  Til RICHARDSEN

IPC分类号： B01D15/14 ,  G01N30/60

CPC分类号： B01D15/14 ,  G01N30/6026 ,  G01N30/6078 ,  G01N2030/027

摘要： A plug unit configured for use in high performance liquid chromatography is described. The plug unit comprises a capillary comprising a capillary distal face; a sealing element, wherein at least a portion of the sealing element is located distal from the capillary distal face; and a biasing element configured to bias the capillary towards the sealing element.

公开(公告)号：US20180348179A1

公开(公告)日：2018-12-06

申请号：US15996127

申请日：2018-06-01

申请人： Phoenix S&T, Inc.

发明人： Sau Lan Tang Staats

IPC分类号： G01N30/72 ,  H01J49/04 ,  H01J49/16 ,  G01N30/60 ,  C25D1/02 ,  C22C19/00 ,  C22C19/05

CPC分类号： G01N30/7266 ,  C22C19/002 ,  C22C19/05 ,  C25D1/02 ,  G01N30/6004 ,  G01N30/6078 ,  G01N2030/6013 ,  H01J49/0445 ,  H01J49/165 ,  H01J49/167

摘要： A new electrospray emitter capable of cone-jet mode spray for liquid flow-rates from sub-microliter/minute to 10's of microliters/minute is provided. The high efficiency of ionization and vaporization enabled by the disclosed spray emitter provides improved sensitivity for mass spectrometer detection. The disclosed spray emitter sprays consistently and robustly a liquid buffer having a large range of compositions of aqueous and organic solvents, and is not sensitive to the polarity of the electric field used to induce spray. The fluidic channel leading to the spray emitter opening does not have an internal taper rendering the spray emitter clog-resistant.

公开(公告)号：US09555394B2

公开(公告)日：2017-01-31

申请号：US14046302

申请日：2013-10-04

申请人： Abdul Malik ,  Anne M. Shearrow

发明人： Abdul Malik ,  Anne M. Shearrow

IPC分类号： G01N30/60 ,  B01J20/291 ,  B01J20/26 ,  B01J20/32 ,  G01N30/00 ,  G01N30/56

CPC分类号： B01J20/291 ,  B01J20/26 ,  B01J20/3217 ,  B01J20/3225 ,  B01J20/3272 ,  B01J2220/52 ,  B01J2220/86 ,  G01N30/6078 ,  G01N2030/009 ,  G01N2030/567

摘要： Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which provides phosphonium-based, pyridinium-based, and imidazolium-based IL-mediated advanced sol-gel organic-inorganic hybrid materials for capillary microextraction. Scanning electron microscopy results demonstrate that ILs can serve as porogenic agents in sol-gel reactions. IL-mediated sol-gel coatings prepared with silanol-terminated polymers provided up to 28 times higher extractions compared to analogous sol-gel coatings prepared without any IL in the sol solution. This study shows that IL-generated porous morphology alone is not enough to provide effective extraction media: careful choice of the organic polymer and the precursor with close sol-gel reactivity must be made to ensure effective chemical bonding of the organic polymer to the created sol-gel material to be able to provide the desired sorbent characteristics.

摘要翻译： 离子液体（IL）介导的溶胶 - 凝胶杂化有机 - 无机材料在分析微萃取中有巨大的潜力。 实现这一前景的一个障碍来自于高粘度的ILs显着减慢溶胶 - 凝胶反应。 开发了一种提供用于毛细管微萃取的基于鏻，吡啶鎓和咪唑鎓的IL介导的高级溶胶 - 凝胶有机 - 无机杂化材料的方法。 扫描电子显微镜结果表明，ILs可作为溶胶 - 凝胶反应中的致孔剂。 与溶胶溶液中没有任何IL制备的类似溶胶 - 凝胶涂层相比，用硅烷醇封端的聚合物制备的IL介导的溶胶 - 凝胶涂层提供高达28倍的提取量。 这项研究表明，单独的IL产生的多孔形态不足以提供有效的提取介质：必须仔细选择有机聚合物和具有近似溶胶 - 凝胶反应性的前体，以确保有机聚合物与所产生的溶胶的有效化学键合 凝胶材料能够提供所需的吸附剂特性。

公开(公告)号：US20170016856A1

公开(公告)日：2017-01-19

申请号：US15280744

申请日：2016-09-29

申请人： Nuctech Company Limited

发明人： Qingjun Zhang ,  Yuanjing Li ,  Zhiqiang Chen ,  Ziran Zhao ,  Yinong Liu ,  Yaohong Liu ,  Huishao He ,  Qiufeng Ma ,  Weiping Zhu ,  Xiang Zou ,  Jianping Chang ,  Song Liang

IPC分类号： G01N27/62 ,  H01J49/04

CPC分类号： G01N27/622 ,  G01N1/02 ,  G01N1/2211 ,  G01N1/405 ,  G01N1/42 ,  G01N30/60 ,  G01N30/722 ,  G01N2001/028 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/0468 ,  G01N30/6043 ,  G01N30/6078

摘要： A detection apparatus and a detection method are disclosed. In one aspect, the detection apparatus includes a sampling device for collecting samples to be checked. It further includes a sample pre-processing device configured to pre-process the sample from the sampling device. It further includes a sample analyzing device for separating samples from the pre-processing device and for analyzing the separated samples. The detection apparatus is miniaturized and highly precise, and is capable of quickly and accurately detecting gaseous phase or particulate substances, and it has applications for safety inspections at airports, ports, and subway stations.

摘要翻译： 公开了一种检测装置和检测方法。 一方面，检测装置包括用于收集要检查的样品的取样装置。 其还包括被配置为从采样装置预处理样品的样本预处理装置。 其还包括用于从预处理装置分离样品并分析分离的样品的样品分析装置。 该检测装置小型化，精度高，能够快速，准确地检测气相或颗粒物质，并具有在机场，港口，地铁站的安全检查的应用。

公开(公告)号：US20160077066A1

公开(公告)日：2016-03-17

申请号：US14787520

申请日：2014-05-02

申请人： DOW GLOBAL TECHNOLOGIES LLC ,  ROHM AND HAAS COMPANY

发明人： Ronda L. Gras ,  Jim C. Luong ,  Warren E. Smith

IPC分类号： G01N30/72 ,  G01N33/28

CPC分类号： G01N30/7206 ,  C10L1/003 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6078 ,  G01N30/7233 ,  G01N30/88 ,  G01N33/28 ,  G01N33/2882 ,  G01N2030/042 ,  G01N2030/8854

摘要： A gas chromatographic method for detecting a marker compound in a fuel by (a) introducing a sample of fuel into a first capillary column coated with a stationary phase based on polydimethylsiloxane and allowing the sample to flow through the first column to produce a first effluent; (b) allowing the first effluent to pass through a detector and identifying a retention time range in it which includes a retention time of the marker compound; (c) introducing only a portion of the first effluent stream which is within the retention time range into a second capillary column coated with either (i) an ionic sorbent or (ii) a polyethylene glycol, and allowing said portion to flow through the second capillary column to produce a second effluent stream; and (d) allowing the second effluent to pass through a detector; wherein the marker compound has formula Ar(R2)m(OR1)n and is present in the fuel at a level from 0.01 ppm to 100 ppm.

摘要翻译： 一种用于通过以下步骤来检测燃料中的标记化合物的气相色谱方法：（a）基于聚二甲基硅氧烷将样品引入到具有固定相的第一毛细管柱中并使样品流过第一塔以产生第一流出物; （b）允许第一流出物通过检测器并鉴定其中包含标记化合物的保留时间的保留时间范围; （c）将仅在保留时间范围内的第一流出物流的一部分引入涂覆有（i）离子吸附剂或（ii）聚乙二醇的第二毛细管柱中，并允许所述部分流过第二流出物流 毛细管柱以产生第二流出物流; 和（d）允许第二流出物通过检测器; 其中标记化合物具有式Ar（R 2）m（OR 1）n，并且以0.01ppm至100ppm的水平存在于燃料中。

公开(公告)号：US20140150660A1

公开(公告)日：2014-06-05

申请号：US14170719

申请日：2014-02-03

申请人： Matthew Spangler Klee

发明人： Matthew Spangler Klee

IPC分类号： G01N30/60

CPC分类号： G01N30/60 ,  B01D53/02 ,  B01D53/025 ,  G01N30/10 ,  G01N30/12 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/6034 ,  G01N30/6039 ,  G01N30/6078 ,  G01N2030/025 ,  G01N2030/167 ,  G01N2030/6008

摘要： A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions. The arresting aspect of the taper simplifies the process of capillary tubing installation while ensuring that the tubing will reproducibly be positioned in the taper. One or more features of the taper prevent tubing from seizing within the taper so that the devices can be reused and ensure that there is open space for a portion of gas to flow around and past the tubing. The angle of the taper, the dimensions of the taper, and the nature of the features within the taper can be adjusted to meet specific performance, usability and/or manufacturability requirements.

摘要翻译： 用于气相色谱法中吹扫的毛细管连接件的非卡住锥度，可在安装过程中将毛细管管道停止在锥度内的可预测位置，并保持气体流过毛细管的空间。 公开的锥形是通常使用的清洗装置的改进部件，例如入口衬套和清洗的接头。 锥形的阻止方面简化了毛细管安装的过程，同时确保管道可重复地定位在锥度中。 该锥度的一个或多个特征防止管道在锥形内被卡住，使得装置可以重复使用，并且确保有一部分气体围绕并流过管道的开放空间。 可以调节锥度的角度，锥度的尺寸以及锥度内的特征的性质以满足特定性能，可用性和/或可制造性要求。

公开(公告)号：US08329038B2

公开(公告)日：2012-12-11

申请号：US12947435

申请日：2010-11-16

申请人： William H. Steinecker

发明人： William H. Steinecker

IPC分类号： B01D15/08

CPC分类号： B01D15/206 ,  C23C18/122 ,  C23C18/125 ,  C23C18/1254 ,  C25D5/028 ,  C25D5/16 ,  C25D5/18 ,  C25D7/04 ,  G01N30/56 ,  G01N30/6065 ,  G01N30/6078 ,  G01N2030/567

摘要： Methods for depositing a stationary phase in a tube for chromatography. The resulting column may be a variable gradient column or a standard open tubular column with a uniform thickness stationary phase. The methods include providing a tube comprising an electrically conductive interior surface and having a composition within the tube, the composition comprising a stationary phase precursor and at least one of an electrolyte and a reactant precursor, and electrochemically reacting the reactant precursor or the stationary phase precursor to form a stationary phase in the tube.

摘要翻译： 将固定相沉积在色谱管中的方法。 得到的柱可以是可变梯度柱或具有均匀厚度固定相的标准开放管状柱。 所述方法包括提供包含导电内表面并且在管内具有组成的管，该组合物包含固定相前体和电解质和反应物前体中的至少一种，并将反应物前体或固定相前体电化学反应 以在管中形成固定相。

公开(公告)号：US08197694B1

公开(公告)日：2012-06-12

申请号：US12750152

申请日：2010-03-30

申请人： Chaodong Jin ,  Qiangwei Xia

发明人： Chaodong Jin ,  Qiangwei Xia

IPC分类号： B01D15/08

CPC分类号： G01N30/6047 ,  G01N30/6078 ,  G01N30/6091

摘要： A holder for capillary columns (130) is realized by a mechanical holding device, also called a lead holder, which can be a mechanical pencil. The user holds the holding device in one hand and presses on an actuator (100) at the top of the holder, springably urging a plurality of jaws (115) to open. The user then slidably inserts the capillary column into the holder a desired distance and releases the actuator, causing the jaws to close around the capillary column and hold it in position within the holder. Next, a cap (140, 140′) is optionally slidably urged over the end of the holder in order to protect the exposed tip (135) of the capillary column. Removal of the capillary column is accomplished by reversing the above procedure to release the capillary column, allowing the column to be withdrawn.

摘要翻译： 用于毛细管柱（130）的保持器通过机械夹持装置（也称为引线架）实现，其可以是自动铅笔。 使用者用一只手握住保持装置并按压在保持器的顶部的致动器（100）上，弹性地推动多个钳口（115）打开。 然后用户将毛细管柱可滑动地插入保持器所需的距离并释放致动器，使得钳口围绕毛细管柱闭合并将其保持在保持器内的适当位置。 接下来，帽（140,140'）可选地可滑动地推动在保持器的端部上，以便保护毛细管柱的暴露尖端（135）。 通过反转上述程序来释放毛细管柱来实现毛细管柱的去除，以释放毛细管柱。

公开(公告)号：US20110284466A1

公开(公告)日：2011-11-24

申请号：US13112519

申请日：2011-05-20

申请人： Chao-Jung Chen ,  Mei-Chun Tseng ,  Yet-Ran Chen

发明人： Chao-Jung Chen ,  Mei-Chun Tseng ,  Yet-Ran Chen

IPC分类号： B01D15/08 ,  C04B35/64 ,  B05D3/00 ,  B05D7/22 ,  B05D3/02

CPC分类号： G01N30/603 ,  B01D15/22 ,  G01N30/6078

摘要： A durable on-column tunneled frit was developed for use in nanoflow UPLC systems. The frit was tunneled during sol-gel reaction. The tunneled-frit fabrication process is easy and reproducible in terms of back pressure and durability. This design creates low backpressure with high liquid flow, which is suitable for the nanoflowUPLC application. A short packing (2 cm C18 particle) tunneled-frit column was demonstrated to sustain 10,000 psi continuous liquid flow for over one week without any particle leakage or pressure instability. The tunneled-frit was also successfully applied to the fabrication of nanoUPLC trapping and analytical column system. It was demonstrated to have high separation efficiency and sensitivity for the analysis of tryptic peptides as well as improved detection sensitivity for phosphopeptide analysis.

摘要翻译： 开发了一种耐用的柱内隧道玻璃料，用于纳流低压UPLC系统。 玻璃料在溶胶 - 凝胶反应过程中被隧道化。 隧道式玻璃料制造工艺在背压和耐久性方面是容易的和可再现的。 该设计产生低液压，具有高液体流量，适用于纳米FLUP应用。 证明短填料（2cm C18颗粒）隧道玻璃料柱能够持续10,000psi连续液流超过一周，没有任何颗粒泄漏或压力不稳定性。 隧道玻璃料也成功应用于nanoUPLC捕集和分析柱系统的制造。 已被证明具有高分离效率和敏感性，用于分析胰蛋白酶肽，以及提高磷酸肽分析的检测灵敏度。