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16 条记录 (耗时 0.016 秒)

    Cardiac implant device tether system and method
    2.
    发明授权
    Cardiac implant device tether system and method 有权

    公开(公告)号：US07011671B2

    公开(公告)日：2006-03-14

    申请号：US10198261

    申请日：2002-07-16

    申请人： Jeffrey Welch

    发明人： Jeffrey Welch

    IPC分类号： A61M29/00

    CPC分类号： A61F2/01 ,  A61F2230/0006

    摘要： Catheterization apparatus for implanting devices is provided with a device tether. The apparatus includes a device delivery tube that provides a pathway for moving implant devices through a patient's vasculature to internal body cavities. The implant devices are carried or pushed through the device delivery tube by a tubular push rod. The implant devices are tethered to a line passing through the push rod lumen. After deployment, the implant devices may be retracted into the device delivery tube for repositioning or retrieval by pulling on the tether.

    Method and apparatus for providing an inflatable cushion for use with a vehicle door
    4.
    发明申请
    Method and apparatus for providing an inflatable cushion for use with a vehicle door 有权
    用于提供用于车门的充气垫的方法和装置

    公开(公告)号：US20050057024A1

    公开(公告)日：2005-03-17

    申请号：US10864669

    申请日：2004-06-09

    申请人： Douglas Weston ,  Jeffrey Welch ,  Mark Steinbach

    发明人： Douglas Weston ,  Jeffrey Welch ,  Mark Steinbach

    IPC分类号： B60R21/20 ,  B60R21/21 ,  B60R21/16

    CPC分类号： B60R21/21

    摘要： An airbag device for use with a vehicle door having a window, the airbag device comprising: an inflatable cushion having a predetermined shape, the predetermined shape being configured to have a periphery larger than the periphery of the window of the door when the inflatable cushion is inflated; a backing plate for mounting the inflatable cushion in a desired location, the backing plate providing a reaction surface for a portion of the inflatable cushion as it is being inflated; an inflator for providing an inflation output to the inflatable cushion; and a conduit for providing fluid communication between the inflator and the inflatable cushion, the conduit having a diffuser portion disposed within the inflatable cushion, the diffuser portion having a plurality of diffuser openings for allowing the inflation output to be received within the inflatable cushion, wherein inflation of the inflatable cushion by the inflator will cause portions of the inflatable cushion to overlap the periphery of the window opening such that a retentive covering is provided over the window.

    摘要翻译： 一种与具有窗口的车门一起使用的安全气囊装置，所述气囊装置包括：具有预定形状的充气垫，当所述可充气衬垫是可膨胀衬垫时，所述预定形状被配置为具有大于门窗口周边的周边 充气 用于将可充气垫安装在所需位置的背板，所述背板在充气垫的一部分被充气时提供反作用表面; 用于向充气垫提供充气输出的充气机; 以及用于在所述充气器和所述可膨胀垫之间提供流体连通的导管，所述导管具有设置在所述可膨胀垫内的扩散器部分，所述扩散器部分具有多个扩散器开口，用于允许所述充气输出容纳在所述可充气垫内，其中 通过充气机对充气垫的充气将导致可充气衬垫的一部分与窗口的周边重叠，使得保持性覆盖物设置在窗户上方。

    Expandable implant devices for filtering blood flow from atrial appendages
    7.
    发明授权
    Expandable implant devices for filtering blood flow from atrial appendages 有权
    用于过滤心房血流的可扩展植入装置

    公开(公告)号：US08197527B2

    公开(公告)日：2012-06-12

    申请号：US11185425

    申请日：2005-07-19

    申请人： Thomas E Borillo ,  Dean Peterson ,  Gregg S Sutton ,  Jeffrey Welch

    发明人： Thomas E Borillo ,  Dean Peterson ,  Gregg S Sutton ,  Jeffrey Welch

    IPC分类号： A61F2/06

    CPC分类号： A61F2/013 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00575 ,  A61F2/01 ,  A61F2002/015 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069 ,  A61F2230/008

    摘要： Implant devices for filtering blood flowing through the ostium of an atrial appendage have component structures one or more of which are expandable. Devices with component structures in their unexpanded state have a compact size suitable for intra-cutaneous delivery to an atrial appendage situs. The expandable component structures are expanded in situ to deploy the devices. A device may have sufficiently short axial length so that most or almost all of the device length may fit within the ostium region. An expandable component structure in the device may include a blood-permeable filter element. The device may be deployed so that this component structure covers the ostium so as to direct the blood flow to pass through the filter element. The filter elements used in the devices may have hole size distributions selected to filter out harmful-size emboli. The filter elements may be embedded in elastic material so that hole-size distributions remain substantially unaffected by expansion of the device structures. Anchors attached to a component structure engage tissue surrounding the device and maintain the devices in position. The anchors may include inflatable anchors which engage interior walls of the atrial appendage.

    摘要翻译： 用于过滤血流通过心房的口的植入装置具有其中一个或多个可膨胀的部件结构。 具有未膨胀状态的组件结构的装置具有适合于皮内递送至心房附属部位的紧凑尺寸。 可扩展组件结构在现场扩展以部署设备。 装置可以具有足够短的轴向长度，使得装置长度的大部分或几乎全部可以适合于口腔区域。 该装置中的可扩张组件结构可包括透血过滤元件。 该装置可以部署成使得该部件结构覆盖口，以引导血液流过过滤元件。 在装置中使用的过滤器元件可以具有选择用于过滤有害尺寸栓塞的孔尺寸分布。 过滤元件可以嵌入弹性材料中，使得孔尺寸分布基本上不受设备结构的膨胀的影响。 附接到部件结构的锚点接合设备周围的组织并将设备维持在适当位置。 锚定器可以包括接合心房内壁附近的充气锚。

    SAPAP3 knockout mouse and clinical modeling associated with the SAPAP3 gene
    9.
    发明申请
    SAPAP3 knockout mouse and clinical modeling associated with the SAPAP3 gene 审中-公开
    SAPAP3敲除小鼠和与SAPAP3基因相关的临床模型

    公开(公告)号：US20080113915A1

    公开(公告)日：2008-05-15

    申请号：US11973304

    申请日：2007-10-05

    申请人： Jeffrey Welch ,  Guoping Feng

    发明人： Jeffrey Welch ,  Guoping Feng

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61P25/00 ,  C12Q1/68 ,  G01N33/00

    CPC分类号： C12Q1/6883 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/17 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2800/301

    摘要： Provided is a transgenic knockout mouse whose genome includes a disruption in its endogenous SAPAP3 gene, wherein the disruption results in the mouse exhibiting increased levels of anxiety as compared to a wild type mouse. Also provided are cells derived from the disclosed transgenic knockout mouse. Also provided are methods of identifying a therapeutic agent for the treatment of an individual diagnosed with anxiety, methods for diagnosing an individual with a clinical disorder associated with reduced expression of a SAPAP3 gene product, and methods for treating an individual with a clinical anxiety disorder associated with reduced expression of a SAPAP3 gene product.

    摘要翻译： 提供了一种转基因敲除小鼠，其基因组包含其内源性SAPAP3基因的破坏，其中与野生型小鼠相比，破坏导致小鼠表现出增加的焦虑水平。 还提供了衍生自所公开的转基因敲除小鼠的细胞。 还提供了鉴定用于治疗患有焦虑症的个体的治疗剂的方法，用于诊断与SAPAP3基因产物的表达降低相关的临床病症的个体的方法，以及用于治疗患有临床焦虑症的个体的方法 降低SAPAP3基因产物的表达。