公开(公告)号：US06652556B1

公开(公告)日：2003-11-25

申请号：US09697628

申请日：2000-10-26

申请人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

发明人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

IPC分类号： A61M2900

CPC分类号： A61F2/01 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0093

摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure comprising a plurality of fingers which are radially outwardly expandable with respect to a longitudinal axis to permanently engage the interior wall of the left atrial appendage, wherein the filtering membrane is attached to the support structure extending across the ostium of the left atrial appendage.

摘要翻译： 用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。 过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。 所述装置还包括支撑结构，所述支撑结构包括多个指状物，所述多个指状物相对于纵向轴线径向向外可膨胀，以永久地接合左心耳内壁，其中所述过滤膜连接到所述支撑结构， 左心耳。

公开(公告)号：US06689150B1

公开(公告)日：2004-02-10

申请号：US09614091

申请日：2000-07-11

申请人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

发明人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

IPC分类号： A61M2900

CPC分类号： A61F2/01 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0093

摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

公开(公告)号：US06652555B1

公开(公告)日：2003-11-25

申请号：US09642291

申请日：2000-08-18

申请人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

发明人： Robert A. VanTassel ,  Robert G. Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S. Sutton ,  Thomas E. Borillo ,  Jeffrey Welch

IPC分类号： A61M2900

CPC分类号： A61B17/12136 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/0643 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12131 ,  A61B17/12159 ,  A61B17/12172 ,  A61B17/122 ,  A61B2017/00243 ,  A61B2017/00628 ,  A61B2017/0641 ,  A61B2017/081 ,  A61B2017/1205 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069 ,  A61F2230/008

摘要： A membrane applied to the ostium of an atrial appendage is disclosed. The membrane prevents blood clots in the atrial appendage from escaping therefrom and entering the blood stream which can result in a blocked blood vessel, leading to strokes and heart attacks. The membrane may be permeable or impermeable with respect to blood flow. The membrane is configured to extend over the ostium of the left atrial appendage. The membrane has an outer periphery with a dimension larger than a corresponding dimension of the ostium. Securement means is provided to secure the outer periphery of the membrane in direct engagement with the atrial wall surrounding the ostium. The securement means may located between the membrane and the atrial wall, or the securement means may extend distally from the membrane through the ostium.

摘要翻译： 公开了应用于心房的口的膜。 膜防止心耳中的血块从其中逸出并进入血流，导致血管阻塞，导致中风和心脏病发作。 膜可以相对于血液流动是可渗透的或不可渗透的。 膜被配置为延伸超过左心耳的口。 膜具有尺寸大于口的相应尺寸的外周。 提供安全装置以固定膜的外周与围绕口的心房壁直接接合。 固定装置可以位于膜和心房壁之间，或者固定装置可以从膜向远侧延伸通过口。

公开(公告)号：US08685055B2

公开(公告)日：2014-04-01

申请号：US10656647

申请日：2003-09-04

申请人： Robert A VanTassel ,  Robert G Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S Sutton ,  Thomas E Borillo ,  Jeffrey Welch

发明人： Robert A VanTassel ,  Robert G Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S Sutton ,  Thomas E Borillo ,  Jeffrey Welch

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0093

摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

摘要翻译： 用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。 过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。 该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。 支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。 过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置例如膨胀气囊通过的第二尺寸，并且其中开口是弹性的 偏向于第一大小。

公开(公告)号：US07727189B2

公开(公告)日：2010-06-01

申请号：US10644388

申请日：2003-08-19

申请人： Robert A VanTassel ,  Robert G Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S Sutton ,  Thomas E Borillo ,  Jeffrey Welch

发明人： Robert A VanTassel ,  Robert G Hauser ,  Robert Schwartz ,  David Holmes ,  Gregg S Sutton ,  Thomas E Borillo ,  Jeffrey Welch

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0093

摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure comprising a plurality of fingers which are radially outwardly expandable with respect to a longitudinal axis to permanently engage the interior wall of the left atrial appendage, wherein the filtering membrane is attached to the support structure extending across the ostium of the left atrial appendage.

摘要翻译： 用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。 过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。 所述装置还包括支撑结构，所述支撑结构包括多个指状物，所述多个指状物相对于纵向轴线径向向外可膨胀，以永久地接合左心耳内壁，其中所述过滤膜连接到所述支撑结构， 左心耳。

公开(公告)号：US20070065879A1

公开(公告)日：2007-03-22

申请号：US11516020

申请日：2006-09-05

申请人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

发明人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

IPC分类号： G01N33/53

CPC分类号： G01N33/5091 ,  C07K14/4715 ,  G01N33/564 ,  G01N33/689 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/368

摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

摘要翻译： 描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

公开(公告)号：US20050136498A1

公开(公告)日：2005-06-23

申请号：US11062400

申请日：2005-02-22

申请人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

发明人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

IPC分类号： G01N33/53 ,  A61B5/055 ,  A61B8/12 ,  A61K51/00 ,  C07K14/47 ,  C12Q1/48 ,  C12Q1/56 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68 ,  G01T1/00 ,  G01T1/161 ,  G01N33/537 ,  G01N33/543

CPC分类号： G01N33/5091 ,  C07K14/4715 ,  G01N33/564 ,  G01N33/689 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/368

摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

摘要翻译： 描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

公开(公告)号：US20070270740A1

公开(公告)日：2007-11-22

申请号：US11750131

申请日：2007-05-17

申请人： David Holmes ,  Robert Schwartz

发明人： David Holmes ,  Robert Schwartz

IPC分类号： A61M25/00

CPC分类号： A61B17/3207 ,  A61B17/22 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2017/00252 ,  A61B2017/22044 ,  A61B2017/22067 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2018/1425

摘要： A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.

摘要翻译： 用于将处理物质输送到管状容器的内腔中的闭塞的导管输送系统包括管状导管和处理物质。 管状导管包括中心腔，其通过邻近可膨胀气囊的近端和远端之间。 治疗物质是被构造成可以通过导管的中央腔输送到管状血管的腔中并在血管中固化的形式。

公开(公告)号：US20060110773A1

公开(公告)日：2006-05-25

申请号：US11254224

申请日：2005-10-18

申请人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

发明人： Cheryl Conover ,  Antonio Bayes-Genis ,  David Holmes ,  Robert Schwartz

IPC分类号： G01N33/53

CPC分类号： G01N33/5091 ,  C07K14/4715 ,  G01N33/564 ,  G01N33/689 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/368

摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.

公开(公告)号：US20050165354A1

公开(公告)日：2005-07-28

申请号：US11087490

申请日：2005-03-22

申请人： Robert Schwartz ,  Robert Van Tassel ,  David Holmes

发明人： Robert Schwartz ,  Robert Van Tassel ,  David Holmes

IPC分类号： A61B17/00 ,  A61B17/34 ,  A61M5/145 ,  A61M5/158 ,  A61M5/168 ,  A61M5/31 ,  A61M5/32 ,  A61M25/00 ,  A61M1/00

CPC分类号： A61M5/158 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M5/14546 ,  A61M5/16813 ,  A61M5/3291 ,  A61M2005/14513 ,  A61M2005/3123 ,  A61M2025/0008 ,  A61M2025/0057 ,  A61M2025/0079 ,  A61M2025/0081 ,  A61M2025/0091

摘要： A medical device is provided having a needle or a catheter, insertable into a living body, which defines a plurality of holes in fluid communication with a central lumen. The holes may be of various patterns located and angled to create a desired injectate cloud pattern when an injectate is forced through the central lumen and through the plurality of holes. One embodiment provides various designs including a moveable sheath or stylet used to selectively occlude one or more of the holes while in use, thereby providing an operating physician a way to manipulate the cloud pattern anytime during the introduction of the injectate. A reducer may be used in conjunction with these needles which provides an increased degree of control when injecting very small quantities of fluid.

摘要翻译： 提供具有可插入生物体中的针或导管的医疗装置，其限定与中心腔流体连通的多个孔。 当注射剂被迫穿过中心腔并穿过多个孔时，孔可以是各种图案，其定位和成角度以产生期望的注射云图案。 一个实施例提供了各种设计，包括用于在使用中选择性地闭塞一个或多个孔的可移动护套或探针，从而为操作医师提供在注射器引入期间随时操作云图案的方式。 减速器可以与这些针结合使用，当注射非常少量的流体时，可以提供更高程度的控制。