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公开(公告)号：US08779098B2
公开(公告)日：2014-07-15
申请号：US12413483
申请日：2009-03-27
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US20140328857A1
公开(公告)日：2014-11-06
申请号：US14294935
申请日：2014-06-03
IPC分类号： C07K16/30 , A61N5/10 , A61K47/48 , A61K39/395 , A61K45/06
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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3.发明授权RAAG10 cell surface target and a family of antibodies recognizing that target 有权RAAG10细胞表面靶标和识别该靶标的一系列抗体公开(公告)号：US07527969B2
公开(公告)日：2009-05-05
申请号：US10600802
申请日：2003-06-19
IPC分类号： C12N1/20
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US07572895B2
公开(公告)日：2009-08-11
申请号：US11147942
申请日：2005-06-07
CPC分类号： C07K16/2881 , A61K39/39533 , A61K2039/505 , C07K16/2863 , C07K2317/77 , Y10S530/808 , Y10S530/809 , A61K2300/00
摘要： The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cancers and diseases that express transferrin receptor.
摘要翻译： 本发明提供了疾病和癌症相关抗原转铁蛋白受体的进一步表征。 本发明还提供了结合转铁蛋白受体的新型抗体家族，诊断和治疗表达转铁蛋白受体的各种人类癌症和疾病的方法。
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公开(公告)号：US08187594B2
公开(公告)日：2012-05-29
申请号：US12483774
申请日：2009-06-12
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/2881 , A61K39/39533 , A61K2039/505 , C07K16/2863 , C07K2317/77 , Y10S530/808 , Y10S530/809 , A61K2300/00
摘要： The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cancers and diseases that express transferrin receptor.
摘要翻译： 本发明提供了疾病和癌症相关抗原转铁蛋白受体的进一步表征。 本发明还提供了结合转铁蛋白受体的新型抗体家族，诊断和治疗表达转铁蛋白受体的各种人类癌症和疾病的方法。
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公开(公告)号：US07776328B2
公开(公告)日：2010-08-17
申请号：US12495218
申请日：2009-06-30
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US20100086969A1
公开(公告)日：2010-04-08
申请号：US12627335
申请日：2009-11-30
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US07569672B2
公开(公告)日：2009-08-04
申请号：US11349327
申请日：2006-02-06
IPC分类号： C07K16/00 , C12N5/12 , A61K39/395
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US08309354B2
公开(公告)日：2012-11-13
申请号：US12018126
申请日：2008-01-22
CPC分类号： C12N5/0695
摘要： This invention discloses isolated populations of human cancer stem cells. Methods for characterizing, isolating and culturing human cancer stem cells are also disclosed. Uses for human cancer stem cells are provided.
摘要翻译： 本发明公开了人类癌症干细胞的分离群体。 还公开了表征，分离和培养人类癌症干细胞的方法。 提供用于人类癌症干细胞的用途。
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公开(公告)号：US08216578B2
公开(公告)日：2012-07-10
申请号：US12497439
申请日：2009-07-02
IPC分类号： A61K39/395
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K16/30 , C07K2317/73 , G01N33/574 , G01N2333/715
摘要： The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.
摘要翻译： 本发明提供了疾病和癌症相关抗原的表征，OSM-R.beta。 本发明还提供OSM-R.beta的调节剂，其包括与抗原OSM-R.beta结合的单克隆抗体家族，以及诊断和治疗与OSM-R.beta相关的各种人类癌症和疾病的方法。
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