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公开(公告)号：US07968536B2
公开(公告)日：2011-06-28
申请号：US12164905
申请日：2008-06-30
申请人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20090005359A1
公开(公告)日：2009-01-01
申请号：US12164905
申请日：2008-06-30
申请人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/55 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/519
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US08293752B2
公开(公告)日：2012-10-23
申请号：US12164762
申请日：2008-06-30
申请人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/535 , A61K31/52 , C07D239/42 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20090036419A1
公开(公告)日：2009-02-05
申请号：US12164762
申请日：2008-06-30
申请人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/397 , C07D239/24 , A61K31/505 , C07D295/00 , C07D473/00 , C12N9/99 , A61P9/00 , A61P37/02 , A61P31/12 , A61P19/08 , A61P29/00 , A61P25/00 , A61P35/00 , A61K31/52 , A61K31/5377 , A61K31/496 , A61K31/502
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20120040951A1
公开(公告)日：2012-02-16
申请号：US13142603
申请日：2009-12-30
申请人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
发明人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
IPC分类号： A61K31/437 , A61K31/5377 , C07D417/14 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/12 , A61P19/08 , A61P1/16 , A61P7/00 , A61P3/10 , C12N9/99 , C07D471/04
CPC分类号： C07D261/08 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20100324039A1
公开(公告)日：2010-12-23
申请号：US12871293
申请日：2010-08-30
IPC分类号： A61K31/5377 , C07D417/06 , A61K31/428 , C07D209/10 , A61K31/405 , C07D413/14 , A61P3/10 , A61P13/12 , A61P25/00 , A61P27/02
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20120270912A1
公开(公告)日：2012-10-25
申请号：US13534875
申请日：2012-06-27
IPC分类号： A61K31/405 , C07D209/10 , A61K31/428 , A61P25/00 , A61P27/12 , A61P9/10 , A61P13/12 , C07D417/06 , A61P3/10
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US06730794B2
公开(公告)日：2004-05-04
申请号：US10185863
申请日：2002-06-28
IPC分类号： C07D41700
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US06214991B1
公开(公告)日：2001-04-10
申请号：US09282280
申请日：1999-03-31
IPC分类号： C07D41706
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
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公开(公告)号：US08163932B2
公开(公告)日：2012-04-24
申请号：US12701967
申请日：2010-02-08
IPC分类号： C07D417/06 , C07D209/04 , A61K31/535 , A61K31/425 , A61K31/40
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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