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公开(公告)号：US10980882B2
公开(公告)日：2021-04-20
申请号：US15273098
申请日：2016-09-22
IPC分类号： A61K41/00 , A61K9/00 , A61K47/34 , A61K9/06 , A61K9/50 , A61K38/18 , A61K47/36 , C07K16/22 , A61K39/00
摘要： A hydrogel delivery composition, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent.
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公开(公告)号：US20140065226A1
公开(公告)日：2014-03-06
申请号：US13261732
申请日：2012-03-05
申请人： Eric Brey , Jennifer J. Kang-Mieler , Victor Perez-Luna , Bin Jiang , Pawel Drapala , Rolf Schäfer , Hans Hitz
发明人： Eric Brey , Jennifer J. Kang-Mieler , Victor Perez-Luna , Bin Jiang , Pawel Drapala , Rolf Schäfer , Hans Hitz
IPC分类号： A61K47/32 , A61K31/573
CPC分类号： A61K47/32 , A61K9/0014 , A61K9/0048 , A61K9/06 , A61K9/5153 , A61K31/573 , A61K47/34
摘要： A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having a side chain-linked amino acid. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nano-particle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.
摘要翻译： 一种热响应性水凝胶，包括具有侧链连接的氨基酸的生物相容性单体和/或聚合物。 水凝胶在生理温度下是热响应的，并且可以包括，掺入或包封处理剂，例如药物组合物，生物分子和/或纳米颗粒。 水凝胶可用于递送处理剂。 水凝胶处于哺乳动物的第一物理化学状态。 水凝胶在哺乳动物的生理温度下是热应答的，并且变成比第一物理化学状态更固体的第二物理化学状态。 在第二个物理化学状态下，热响应性水凝胶释放处理剂。
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3.发明授权公开(公告)号：US11266608B2
公开(公告)日：2022-03-08
申请号：US16845184
申请日：2020-04-10
摘要： A hydrogel delivery composition and method, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent. The degradable microcapsules include one or more of magnesium hydroxide (Mg(OH)2), bovine serum albumin (BSA), polyethylene glycol (PEG), and sucrose to improve release duration.
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