公开(公告)号：US20140065226A1

公开(公告)日：2014-03-06

申请号：US13261732

申请日：2012-03-05

申请人： Eric Brey ,  Jennifer J. Kang-Mieler ,  Victor Perez-Luna ,  Bin Jiang ,  Pawel Drapala ,  Rolf Schäfer ,  Hans Hitz

发明人： Eric Brey ,  Jennifer J. Kang-Mieler ,  Victor Perez-Luna ,  Bin Jiang ,  Pawel Drapala ,  Rolf Schäfer ,  Hans Hitz

IPC分类号： A61K47/32 ,  A61K31/573

CPC分类号： A61K47/32 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/5153 ,  A61K31/573 ,  A61K47/34

摘要： A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having a side chain-linked amino acid. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nano-particle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.

摘要翻译： 一种热响应性水凝胶，包括具有侧链连接的氨基酸的生物相容性单体和/或聚合物。 水凝胶在生理温度下是热响应的，并且可以包括，掺入或包封处理剂，例如药物组合物，生物分子和/或纳米颗粒。 水凝胶可用于递送处理剂。 水凝胶处于哺乳动物的第一物理化学状态。 水凝胶在哺乳动物的生理温度下是热应答的，并且变成比第一物理化学状态更固体的第二物理化学状态。 在第二个物理化学状态下，热响应性水凝胶释放处理剂。

公开(公告)号：US10980882B2

公开(公告)日：2021-04-20

申请号：US15273098

申请日：2016-09-22

申请人： Jennifer J. Kang-Mieler

发明人： Jennifer J. Kang-Mieler ,  Eric Brey ,  Victor Perez-Luna ,  Bin Jiang ,  Christian Osswald

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K47/34 ,  A61K9/06 ,  A61K9/50 ,  A61K38/18 ,  A61K47/36 ,  C07K16/22 ,  A61K39/00

摘要： A hydrogel delivery composition, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent.

公开(公告)号：US11266608B2

公开(公告)日：2022-03-08

申请号：US16845184

申请日：2020-04-10

申请人： Jennifer J. Kang-Mieler

发明人： Jennifer J. Kang-Mieler ,  Eric Brey ,  Victor Perez-Luna ,  Bin Jiang ,  Christian Osswald

IPC分类号： A61K9/51 ,  A61K9/06 ,  A61K9/00 ,  A61K9/50

摘要： A hydrogel delivery composition and method, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and/or release of the treatment agent. The degradable microcapsules include one or more of magnesium hydroxide (Mg(OH)2), bovine serum albumin (BSA), polyethylene glycol (PEG), and sucrose to improve release duration.

公开(公告)号：US20070190165A1

公开(公告)日：2007-08-16

申请号：US11585353

申请日：2006-10-23

申请人： Eric Brey ,  Shiri Uriel ,  Edwardine Labay ,  Ralph Weichselbaum

发明人： Eric Brey ,  Shiri Uriel ,  Edwardine Labay ,  Ralph Weichselbaum

IPC分类号： A61K35/12

CPC分类号： A61K35/30 ,  A61K35/36 ,  A61K35/44

摘要： Methods are provided for basement membrane extraction and gellation whereby a biologically active, stable, three dimensional gel can be induced within five minutes or less with basement membrane components from substantially any tissue selected by the preparer. The three dimensional gel can further be substantially free of cellular contaminants. Thus, a wide range of diagnostic and therapeutic uses for such gels can be made available.

摘要翻译： 提供了用于基底膜提取和凝胶化的方法，其中可以在五分钟或更短时间内从基本上由制备者选择的任何组织的基底膜组分诱导生物活性的稳定的三维凝胶。 三维凝胶可以基本上不含细胞污染物。 因此，可以提供这种凝胶的广泛的诊断和治疗用途。

公开(公告)号：US20110306848A1

公开(公告)日：2011-12-15

申请号：US13160592

申请日：2011-06-15

申请人： Holger ENGEL ,  Ming-Huei Cheng ,  Eric Brey ,  Emre Gazyakan

发明人： Holger ENGEL ,  Ming-Huei Cheng ,  Eric Brey ,  Emre Gazyakan

IPC分类号： A61B5/00

CPC分类号： A61B5/0077 ,  A61B5/445 ,  A61F13/00021 ,  A61M37/00

摘要： A wound healing chamber is disclosed, which includes: a fixing plate with a first opening, wherein suturing holes are circularly formed around a peripheral section of the first opening, and the fixing plate is fixed on an object through the suturing holes; and a detachable cap mounted on the fixing plate, wherein the cap corresponds to the first opening, and the first opening is open or closed by the detachable cap.

摘要翻译： 公开了一种伤口愈合腔，其包括：具有第一开口的固定板，其中围绕所述第一开口的周边部分环形地形成缝合孔，并且所述固定板通过所述缝合孔固定在物体上; 以及安装在所述固定板上的可拆卸盖，其中所述盖对应于所述第一开口，并且所述第一开口由所述可拆卸盖打开或关闭。