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    Oligomeric compounds for the modulation of survivin expression
    1.
    发明授权
    Oligomeric compounds for the modulation of survivin expression 失效
    用于调节存活蛋白表达的低聚化合物

    公开(公告)号：US08026355B2

    公开(公告)日：2011-09-27

    申请号：US12765673

    申请日：2010-04-22

    申请人： Jens Bo Rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Jens Bo Rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： C07H21/04

    CPC分类号： C07H21/04

    摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    Oligomeric compounds for the modulation of survivin expression
    2.
    发明授权
    Oligomeric compounds for the modulation of survivin expression 失效
    用于调节存活蛋白表达的低聚化合物

    公开(公告)号：US07741309B2

    公开(公告)日：2010-06-22

    申请号：US12493625

    申请日：2009-06-29

    申请人： Jens Bo Rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Jens Bo Rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： A61K48/00

    CPC分类号： C07H21/04

    摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION
    3.
    发明申请
    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION 失效
    用于调节表达蛋白的低分子化合物

    公开(公告)号：US20090318362A1

    公开(公告)日：2009-12-24

    申请号：US12493625

    申请日：2009-06-29

    申请人： Jens Bo rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Jens Bo rode Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： A61K38/10 ,  A61P35/00

    CPC分类号： C07H21/04

    摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION
    4.
    发明申请
    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION 审中-公开
    用于调节表达蛋白的低分子化合物

    公开(公告)号：US20120088907A1

    公开(公告)日：2012-04-12

    申请号：US13183365

    申请日：2011-07-14

    申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： C07H21/04

    CPC分类号： C07H21/04

    摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION
    5.
    发明申请
    OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION 失效
    用于调节表达蛋白的低分子化合物

    公开(公告)号：US20100292311A1

    公开(公告)日：2010-11-18

    申请号：US12765673

    申请日：2010-04-22

    申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： A61K31/713 ,  A61P35/00

    CPC分类号： C07H21/04

    摘要： Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对存活蛋白基因的寡核苷酸用于调节存活蛋白的表达。 组合物包含针对编码存活蛋白的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活素过表达，突变存活蛋白或两者表达相关的疾病的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    Oligomeric compounds for the modulation ras expression
    6.
    发明申请
    Oligomeric compounds for the modulation ras expression 审中-公开
    用于调节ras表达的低聚化合物

    公开(公告)号：US20080188432A1

    公开(公告)日：2008-08-07

    申请号：US11640123

    申请日：2006-12-15

    申请人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    发明人： Bo Hansen ,  Charlotte Albaek Thrue ,  Majken Westergaard ,  Kamille Dumong Petersen ,  Margit Wissenbach

    IPC分类号： A61K31/7052 ,  C07H21/04

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/33 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346

    摘要： Oligonucleotides directed against the Ha-ras gene are provided for modulating the expression of Ha-ras. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Ha-ras. Methods of using these compounds for modulation of Ha-ras expression and for the treatment of diseases associated with either overexpression of Ha-ras, expression of mutated Ha-ras or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

    摘要翻译： 提供针对Ha-ras基因的寡核苷酸用于调节Ha-ras的表达。 组合物包含针对编码Ha-ras的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节Ha-ras表达和治疗与Ha-ras的过表达有关的疾病，突变型Ha-ras或两者的表达的方法。 疾病的例子包括肺，乳腺，结肠，前列腺，胰腺，肺，肝，甲状腺，肾，脑，睾丸，胃，肠，肠，脊髓，鼻窦，膀胱，尿道或卵巢癌等癌症。 寡核苷酸可以由脱氧核糖核苷或核酸类似物例如锁定的核酸或其组合构成。

    Potent LNA oligonucleotides for the inhibition of HIF-1a expression
    8.
    发明授权
    Potent LNA oligonucleotides for the inhibition of HIF-1a expression 有权
    用于抑制HIF-1a表达的强大的LNA寡核苷酸

    公开(公告)号：US07939507B2

    公开(公告)日：2011-05-10

    申请号：US12477261

    申请日：2009-06-03

    申请人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    发明人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    IPC分类号： A01N43/04 ,  C12Q1/68 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346

    摘要： The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.

    摘要翻译： 本公开内容涉及由选自5' - （Tx）GxGxcsasasgscsastscscsTxGxT-3'和5' - （Gx）TxTxascstsgscscststscscTTTXA-3'的序列组成的LNA寡核苷酸，其中大写字母表示β-D-氧基 -LNA核苷酸类似物，小写字母表示2-脱氧核苷酸，下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸，下标“s”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接，下标 “x”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接或磷酸二酯连接，并且其中该序列任选地延伸多达五个2-脱氧核苷酸单元。 LNA寡核苷酸可用于调节缺氧诱导因子-1a（HIF-1a）的表达，例如， 在治疗癌症疾病，抑制血管发生，诱导细胞凋亡，预防细胞增殖或治疗血管生成疾病，例如， 糖尿病性视网膜病变，黄斑变性（ARMD），牛皮癣，类风湿性关节炎等炎症性疾病。

    Potent LNA oligonucleotides for the inhibition of HIF-1A expression
    10.
    发明授权
    Potent LNA oligonucleotides for the inhibition of HIF-1A expression 有权
    用于抑制HIF-1A表达的强效LNA寡核苷酸

    公开(公告)号：US08410071B2

    公开(公告)日：2013-04-02

    申请号：US13079525

    申请日：2011-04-04

    申请人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    发明人： Majken Westergaard ,  Charlotte Albaek Thrue ,  Frank Winther Rasmussen ,  Henrik Frydenlund Hansen

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12N15/63 ,  A01N43/04 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346

    摘要： The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighboring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighboring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.

    摘要翻译： 本公开内容涉及由选自5' - （Tx）GxGxcsasasgscsastscscsTxGxT-3'和5' - （Gx）TxTxascstsgscscststscscTTTXA-3'的序列组成的LNA寡核苷酸，其中大写字母表示β-D-氧基 -LNA核苷酸类似物，小写字母表示2-脱氧核苷酸，下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸，下标s表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接，下标x表示 在相邻核苷酸/ LNA核苷酸类似物之间是硫代磷酸酯连接或磷酸二酯连接，并且其中所述序列任选地延伸多达五个2-脱氧核苷酸单元。 LNA寡核苷酸可用于调节缺氧诱导因子-1a（HIF-1a）的表达，例如， 在治疗癌症疾病，抑制血管发生，诱导细胞凋亡，预防细胞增殖或治疗血管生成疾病，例如， 糖尿病性视网膜病变，黄斑变性（ARMD），牛皮癣，类风湿性关节炎等炎症性疾病。