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1.发明授权Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases 失效取代的2,5-二氨基吲哚作为治疗心血管疾病的ECE抑制剂公开(公告)号：US07045544B2
公开(公告)日：2006-05-16
申请号：US10490821
申请日：2002-09-16
申请人： Jens-Kerim Ergüden , Thomas Krahn , Christian Schröder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
发明人： Jens-Kerim Ergüden , Thomas Krahn , Christian Schröder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
IPC分类号： A61K31/404 , A61K31/4439 , A61K31/433 , C07D209/40 , C07D405/12
CPC分类号： C07D401/12 , C07D209/42
摘要： The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals
摘要翻译： 本发明涉及式（I）化合物，其制备方法及其用作药物治疗人和/或动物疾病的方法
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2.发明申请Substituted 2 5-diamidoindoles as ece inhibitors for the treatment of cardiovascular diseases 失效取代的2,5-二氨基吲哚作为治疗心血管疾病的ece抑制剂公开(公告)号：US20050038101A1
公开(公告)日：2005-02-17
申请号：US10490821
申请日：2002-09-16
申请人： Jens-Kerim Erguden , Thomas Krahn , Christian Schroder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
发明人： Jens-Kerim Erguden , Thomas Krahn , Christian Schroder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
IPC分类号： A61K31/404 , A61K31/427 , A61K31/433 , A61K31/4439 , A61P9/00 , A61P9/04 , A61P9/10 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/06 , C07D417/06 , C07D417/12 , A61K31/405 , C07D45/02
CPC分类号： C07D401/12 , C07D209/42
摘要： The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，以及其用于治疗人和/或动物疾病的药物。
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3.发明申请Use of substituted 2,5-diamidoindoles for the treatment of urological diseases 审中-公开取代的2,5-二酰氨基吲哚用于治疗泌尿系疾病公开(公告)号：US20060183753A1
公开(公告)日：2006-08-17
申请号：US10539203
申请日：2003-12-06
申请人： Jens Erguden , Thomas Krahn , Christian Schroder , Johannes Stasch , Stefan Weigand , Hanno Wild , Michael Brands , Stehan Siegel , Dirk Heimbach , Jorg Keldenich , Masaomi Tajimi , Hiroko Takagi
发明人： Jens Erguden , Thomas Krahn , Christian Schroder , Johannes Stasch , Stefan Weigand , Hanno Wild , Michael Brands , Stehan Siegel , Dirk Heimbach , Jorg Keldenich , Masaomi Tajimi , Hiroko Takagi
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/405
CPC分类号： A61K31/433 , A61K31/404 , A61K31/405 , A61K31/4439
摘要： The present invention relates to the use of 2,5-diamidoindole derivatives for the preparation of medicaments for treating urological disorders in humans and/or animals.RCK 41-Foreign Countries
摘要翻译： 本发明涉及2,5-二酰氨基吲哚衍生物在制备用于治疗人和/或动物泌尿系统疾病的药物中的用途。
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4.发明申请Use of Activators of Soluble Guanylate Cyclase for Promoting Wound Healing 审中-公开使用可溶性鸟苷酸环化酶的活化剂促进伤口愈合公开(公告)号：US20090221573A1
公开(公告)日：2009-09-03
申请号：US11988351
申请日：2006-07-06
申请人： Thomas Krahn , Johannes-Peter Stasch , Gerrit Weimann , Wolfgang Thielemann , Beatrix Stelte-Ludwig
发明人： Thomas Krahn , Johannes-Peter Stasch , Gerrit Weimann , Wolfgang Thielemann , Beatrix Stelte-Ludwig
IPC分类号： C07D413/12 , C07D471/04 , A61K31/5377 , C07D401/14 , A61K31/195 , C07D413/14 , A61K31/495 , A61K31/44 , C07C229/34
CPC分类号： A61K31/506
摘要： The present invention relates to a method for promoting wound healing by administering one or more compounds identified in the claims, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及一种通过施用权利要求中鉴定的一种或多种化合物和包含这些化合物的药物组合物来促进伤口愈合的方法。
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5.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20060217373A1
公开(公告)日：2006-09-28
申请号：US11443693
申请日：2006-05-30
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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6.发明申请Use of Activators of Soluble Guanylate Cyclase for Treating Reperfusion Damage 审中-公开使用可溶性鸟苷酸环化酶的活化剂治疗再灌注损伤公开(公告)号：US20090298822A1
公开(公告)日：2009-12-03
申请号：US11922838
申请日：2006-07-06
IPC分类号： A61K31/5377 , A61K31/197 , A61K31/506 , A61P7/00
CPC分类号： A61K31/192 , A61K31/195 , A61K31/381 , A61K31/42 , A61K31/422 , A61K31/506 , A61K31/5377
摘要： The present invention relates to the use of compounds for manufacturing a pharmaceutical product/medicament for the prophylaxis and/or treatment of reperfusion damage.
摘要翻译： 本发明涉及化合物在制备用于预防和/或治疗再灌注损伤的药物/药物中的用途。
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7.发明授权Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use 失效取代的2-硫代-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07504421B2
公开(公告)日：2009-03-17
申请号：US11359927
申请日：2006-02-21
申请人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号： C07D213/85 , A61K31/44
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法及其作为广泛医学指征谱的药理学有效物质的用途。 此外，提供选择性腺苷受体配体，优选选择性腺苷A1-，腺苷A2a-和/或腺苷A2b-受体配体用于预防和/或治疗泌尿生殖区疾病，特别是心血管疾病，泌尿生殖系疾病 呼吸道，炎性和神经炎症性疾病，糖尿病，特别是胰腺糖尿病，神经变性疾病，疼痛状态，癌症以及肝纤维化和肝硬化。
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8.发明申请Use of Suluble Guanylate Cyclase Acitvators for Treating Acute and Chronic Lung Diseases 审中-公开使用磺胺鸟苷酸环化酶治疗急性和慢性肺部疾病公开(公告)号：US20090286781A1
公开(公告)日：2009-11-19
申请号：US12083121
申请日：2006-09-23
IPC分类号： A61K31/5377 , C07C229/34 , A61K31/197 , C07D487/04 , A61K31/506 , A61P9/12 , C07D417/12
CPC分类号： A61K31/5377 , A61K31/195 , A61K31/506
摘要： The present invention relates to the use of compounds of the formulae I-VI for manufacturing a pharmaceutical for the treatment of acute and chronic lung disorders such as the respiratory distress syndromes [acute lung injury (ALI), acute respiratory distress syndrome (ARDS)] and the treatment of COPD.
摘要翻译： 本发明涉及式I-VI化合物在制备用于治疗急性和慢性肺部疾病如呼吸窘迫综合征[急性肺损伤（ALI），急性呼吸窘迫综合征（ARDS）]的药物中的用途] 和COPD的治疗。
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9.发明申请Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US20070213372A1
公开(公告)日：2007-09-13
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R 1〜R 7的定义< SUP>如说明书和权利要求书中所述，涉及含有这种化合物的药物组合物，其制备方法和用作治疗心血管疾病和糖尿病的药物。
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公开(公告)号：US20060264432A1
公开(公告)日：2006-11-23
申请号：US11359927
申请日：2006-02-21
申请人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
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