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公开(公告)号：US08410043B2
公开(公告)日：2013-04-02
申请号：US12626375
申请日：2009-11-25
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas C. Boone , Rohini Deshpande , Yue-Sheng Li , Hq Han
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas C. Boone , Rohini Deshpande , Yue-Sheng Li , Hq Han
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
摘要翻译： 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。
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公开(公告)号：US20100168020A1
公开(公告)日：2010-07-01
申请号：US12626375
申请日：2009-11-25
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas C. Boone , Rohini Deshpande , Yue-Sheng Li , Hq Han
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas C. Boone , Rohini Deshpande , Yue-Sheng Li , Hq Han
IPC分类号： A61K38/16 , C07K14/00 , C07H21/00 , C12N15/74 , C12N5/10 , C12P21/00 , A61K31/7088 , A61P21/00
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
摘要翻译： 本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。 本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。
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公开(公告)号：US20110183897A1
公开(公告)日：2011-07-28
申请号：US13080515
申请日：2011-04-05
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , HQ Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , HQ Han , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC分类号： A61K38/16 , C12N15/12 , C12N15/63 , C12N5/00 , C12P21/00 , A61K31/7052 , A61P19/00 , A61P21/00 , A61P3/10 , A61P3/04 , A61P35/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
摘要翻译： 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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公开(公告)号：US20090227497A1
公开(公告)日：2009-09-10
申请号：US12074877
申请日：2008-03-05
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , Han Hq , Keith Soo-Nyung Kwak , Xiaolan Zhou
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , Han Hq , Keith Soo-Nyung Kwak , Xiaolan Zhou
IPC分类号： A61K38/17 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , A61K31/7088
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
摘要翻译： 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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5.发明授权Isolated nucleic acid molecules encoding variant activin receptor polypeptides 有权编码变体激活素受体多肽的分离的核酸分子公开(公告)号：US08716459B2
公开(公告)日：2014-05-06
申请号：US13080515
申请日：2011-04-05
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
摘要翻译： 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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公开(公告)号：US07947646B2
公开(公告)日：2011-05-24
申请号：US12074877
申请日：2008-03-05
IPC分类号： A61K38/00
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
摘要翻译： 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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公开(公告)号：US08501678B2
公开(公告)日：2013-08-06
申请号：US13329897
申请日：2011-12-19
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
CPC分类号： C07K14/705 , A61K31/513 , A61K31/655 , A61K38/177 , A61K38/179 , A61K38/193 , A61K38/2013 , A61K38/212 , A61K38/45 , A61K38/50 , C07K14/71 , C12Y305/01001 , A61K2300/00
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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公开(公告)号：US20120328595A1
公开(公告)日：2012-12-27
申请号：US13329897
申请日：2011-12-19
申请人： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
发明人： Jeonghoon Sun , Lei-Ting Tony Tam , Hui-Quan Han , Keith Soo-Nyung Kwak , Xiaolan Zhou , John Lu
CPC分类号： C07K14/705 , A61K31/513 , A61K31/655 , A61K38/177 , A61K38/179 , A61K38/193 , A61K38/2013 , A61K38/212 , A61K38/45 , A61K38/50 , C07K14/71 , C12Y305/01001 , A61K2300/00
摘要： The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
摘要翻译： 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。
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