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公开(公告)号：US07449486B2
公开(公告)日：2008-11-11
申请号：US11252232
申请日：2005-10-17
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/433 , C07D285/12
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20120270803A1
公开(公告)日：2012-10-25
申请号：US13538698
申请日：2012-06-29
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/433 , A61K31/4439 , A61K38/55 , A61P35/02 , A61P35/00
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20110201651A1
公开(公告)日：2011-08-18
申请号：US13093729
申请日：2011-04-25
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/4439 , C07D417/04 , A61P29/00 , A61P37/06 , A61P19/02 , A61P1/00
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20080182992A1
公开(公告)日：2008-07-31
申请号：US12043456
申请日：2008-03-06
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC分类号： C07D285/12 , C07D271/10
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US08236825B2
公开(公告)日：2012-08-07
申请号：US13093729
申请日：2011-04-25
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/4439 , C07D417/04
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US08623895B2
公开(公告)日：2014-01-07
申请号：US13538698
申请日：2012-06-29
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/433 , A61K31/4439 , C07D417/12 , C07D285/12
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US07956073B2
公开(公告)日：2011-06-07
申请号：US12043456
申请日：2008-03-06
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R Laird , John Robinson , Shelley Allen
IPC分类号： A61K31/433 , C07D285/12
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20060247178A1
公开(公告)日：2006-11-02
申请号：US11415455
申请日：2006-05-01
申请人： Jeremy Hans , Eli Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph Lyssikatos , John Robinson , Christopher Corrette , Robert Delisle
发明人： Jeremy Hans , Eli Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph Lyssikatos , John Robinson , Christopher Corrette , Robert Delisle
IPC分类号： A61K38/05 , A61K38/04 , A61K31/53 , A61K31/501 , A61K31/506 , A61K31/4745 , A61K31/4439 , A61K31/433 , C07D417/02 , C07D285/08
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US20060100161A1
公开(公告)日：2006-05-11
申请号：US11252232
申请日：2005-10-17
申请人： Jeremy Hans , Eli Wallace , Qian Zhao , Joseph Lyssikatos , Thomas Aicher , Ellen Laird , John Robinson , Shelley Allen
发明人： Jeremy Hans , Eli Wallace , Qian Zhao , Joseph Lyssikatos , Thomas Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC分类号： A61K38/04 , A61K31/675 , A61K31/496 , A61K31/4439 , A61K31/433 , A61K31/4245 , C07D417/04 , C07D413/04
CPC分类号： C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US10206081B1
公开(公告)日：2019-02-12
申请号：US15725895
申请日：2017-10-05
申请人： David R. Hall , Craig Boswell , John Robinson
发明人： David R. Hall , Craig Boswell , John Robinson
摘要： Disclosed herein are wireless devices operable at intermediate wireless at ranges of thousands of meters, utilizing packets that include a preamble and a data payload. Devices may be such things as keypads, door latches, occupancy monitors, sprinkler controllers and other devices needing a communications link. Devices include an intermediate-range transceiver and a separate deployment wireless interface accessible from a mobile device such as a cellular telephone or portable tablet. Devices can be registered in a database and deployed for use by means of an application running on the mobile device. A scannable label bearing a code can be affixed to a wireless device providing a means of tracking, identifying and verifying a device through the deployment process. Detailed information on various example embodiments of the inventions are provided in the Detailed Description below, and the inventions are defined by the appended claims.
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