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公开(公告)号：US08580828B2
公开(公告)日：2013-11-12
申请号：US13586355
申请日：2012-08-15
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtil
IPC分类号： A61K31/41 , C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US08268871B2
公开(公告)日：2012-09-18
申请号：US12822066
申请日：2010-06-23
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号： A61K31/41 , C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20130109656A1
公开(公告)日：2013-05-02
申请号：US13586355
申请日：2012-08-15
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号： C07F9/6539 , C07D419/04 , C07D513/04 , C07D417/04
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US07795282B2
公开(公告)日：2010-09-14
申请号：US11415455
申请日：2006-05-01
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC分类号： A61K31/41 , C07D285/14
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
摘要翻译： 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20100331283A1
公开(公告)日：2010-12-30
申请号：US12822066
申请日：2010-06-23
申请人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robisnson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtti
发明人： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robisnson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtti
IPC分类号： A61K31/675 , C07D417/04 , C07D513/04 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07F9/06 , C07D417/14 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5355 , A61K31/542 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/454 , A61P35/00 , A61P31/10 , A61P37/00 , A61P29/00 , A61P9/00
CPC分类号： C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：US20110144085A1
公开(公告)日：2011-06-16
申请号：US13059902
申请日：2009-08-18
申请人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
发明人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC分类号： A61K31/55 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/5377 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
摘要翻译： 其中A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫细胞相关的受体酪氨酸抑制剂 疾病和病症，例如炎性和自身免疫性疾病。
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公开(公告)号：US08557809B2
公开(公告)日：2013-10-15
申请号：US13059881
申请日：2009-08-18
申请人： Shelley Allen , Robert Kirk DeLisle , Julie Marie Greschuk , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
发明人： Shelley Allen , Robert Kirk DeLisle , Julie Marie Greschuk , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D471/04 , A61P35/02 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I): I in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： 式（I）的化合物：其中B，R1，R1a，R2，R3，R4，R5，R6，R7，R10和R11具有本说明书中给出的含义的I是可用于治疗疾病介导的受体酪氨酸抑制剂 通过PIM-1和/或PIM-2和/或PIM-3激酶。
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公开(公告)号：US20110144100A1
公开(公告)日：2011-06-16
申请号：US13059881
申请日：2009-08-18
申请人： Shelley Allen , Robert Kirk DeLisle , Julie Marie Greschuk , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
发明人： Shelley Allen , Robert Kirk DeLisle , Julie Marie Greschuk , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/496 , A61K31/4709 , A61P35/00 , A61P35/02 , A61P29/00 , A61P37/06 , A61P25/28
CPC分类号： C07D471/04
摘要： Compounds of Formula (I): I in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： 式（I）的化合物：其中B，R1，R1a，R2，R3，R4，R5，R6，R7，R10和R11具有本说明书中给出的含义的I是可用于治疗疾病介导的受体酪氨酸抑制剂 通过PIM-1和/或PIM-2和/或PIM-3激酶。
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公开(公告)号：US08575145B2
公开(公告)日：2013-11-05
申请号：US13059902
申请日：2009-08-18
申请人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
发明人： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Greschuk , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC分类号： A61K31/55 , A61K31/437 , A61K31/513 , A61K31/5377 , C07D471/04 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
摘要翻译： 其中A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫细胞相关的受体酪氨酸抑制剂 疾病和病症，例如炎性和自身免疫性疾病。
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公开(公告)号：US20110105463A1
公开(公告)日：2011-05-05
申请号：US13001201
申请日：2009-06-24
申请人： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
发明人： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff
IPC分类号： A61K31/397 , C07D311/02 , A61K31/352 , C07D405/12 , A61K31/4025 , C07D403/12 , A61K31/453 , A61K31/506 , A61K31/4725 , A61P37/00
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
摘要翻译： 式（I）化合物：其中A1，A2，W，L，G，R7a，R7b，R8，R9和R10具有本说明书中给出的含义，是可用于治疗免疫疾病的DP2受体调节剂。
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