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1.发明授权公开(公告)号：US06812227B2
公开(公告)日：2004-11-02
申请号：US10377008
申请日：2003-02-27
申请人： Jeremy I. Levin , James M. Chen , Derek C. Cole , Mila T. Du , Leif M. Laakso
发明人： Jeremy I. Levin , James M. Chen , Derek C. Cole , Mila T. Du , Leif M. Laakso
IPC分类号： A61K3133
CPC分类号： C07C311/29 , A61K31/5375 , A61K31/54 , C07C2601/04 , C07D213/68 , C07D279/10 , C07D279/12 , C07D309/12 , C07F9/36
摘要： Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 下式的化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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2.发明授权Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors 失效乙酰芳基磺酰胺和次膦酸酰胺异羟肟酸TACE抑制剂公开(公告)号：US06762178B2
公开(公告)日：2004-07-13
申请号：US09882704
申请日：2001-06-14
申请人： Jeremy I. Levin , James M. Chen
发明人： Jeremy I. Levin , James M. Chen
IPC分类号： A61K31495
CPC分类号： C07D405/12 , C07C311/29 , C07C2601/04 , C07D213/68 , C07D309/12 , C07F9/36
摘要： Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 具有该化学式的羟肟酸可用于治疗由TNF-α介导的疾病状态，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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3.发明授权Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors 失效含有异羟肟酸化合物的炔基作为基质金属蛋白酶/抑制剂公开(公告)号：US06358980B1
公开(公告)日：2002-03-19
申请号：US09492686
申请日：2000-01-27
申请人： Jeremy I. Levin , Aranapakam M. Venkatesan , James M. Chen , Arie Zask , Vincent P. Sandanayaka , Mila T. Du , Jannie L. Baker
发明人： Jeremy I. Levin , Aranapakam M. Venkatesan , James M. Chen , Arie Zask , Vincent P. Sandanayaka , Mila T. Du , Jannie L. Baker
IPC分类号： A61K31445
CPC分类号： C07D309/08 , A61K31/351 , A61K31/435 , A61K31/445 , A61K31/496 , C07D211/60 , C07D211/62 , C07D211/66
摘要： Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
摘要翻译： 下列化合物：可用于治疗关节炎，肿瘤转移，组织溃疡，创伤愈合异常，牙周病，骨病，糖尿病（胰岛素抵抗）和HIV感染。
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4.发明授权Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors 失效含有异羟肟酸的炔基作为基质金属蛋白酶和TACE抑制剂公开(公告)号：US06825354B2
公开(公告)日：2004-11-30
申请号：US10055502
申请日：2001-11-13
申请人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
发明人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
IPC分类号： C07D21172
CPC分类号： C07D209/48 , C07C317/44 , C07C317/50 , C07C323/60 , C07C2601/14 , C07D207/34 , C07D213/56 , C07D215/48 , C07D215/54 , C07D217/26 , C07D295/088 , C07D309/04 , C07D311/84 , C07D333/20 , C07D333/60 , C07D335/02
摘要： Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 该化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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公开(公告)号：US06313123B1
公开(公告)日：2001-11-06
申请号：US09492974
申请日：2000-01-27
申请人： Jeremy I. Levin , James M. Chen
发明人： Jeremy I. Levin , James M. Chen
IPC分类号： A61K315375
CPC分类号： C07D295/13 , A61K31/5375 , C07C323/49
摘要： The compounds of formula B: which are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss
摘要翻译： 式B化合物，其可用于由TNF-α介导的疾病状态，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失
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6.发明授权Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors 失效杂芳基炔基磺酰胺和次膦酸酰胺异羟肟酸抑制剂公开(公告)号：US06200996B1
公开(公告)日：2001-03-13
申请号：US09492976
申请日：2000-01-27
IPC分类号： A61K3144
CPC分类号： A61K31/44
摘要： Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr; such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 式的化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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7.发明授权Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors 失效含有异羟肟酸化合物的炔基作为基质金属蛋白酶/抑制剂公开(公告)号：US06753337B2
公开(公告)日：2004-06-22
申请号：US10029655
申请日：2001-12-21
申请人： Jeremy I. Levin , Aranapakam M. Venkatesan , James M. Chen , Arie Zask , Vincent P. Sandanayaka , Mila T. Du , Jannie L. Baker
发明人： Jeremy I. Levin , Aranapakam M. Venkatesan , James M. Chen , Arie Zask , Vincent P. Sandanayaka , Mila T. Du , Jannie L. Baker
IPC分类号： A61K31445
CPC分类号： C07D211/62 , A61K31/351 , A61K31/435 , A61K31/445 , A61K31/496 , C07D211/60 , C07D211/66 , C07D309/08
摘要： Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
摘要翻译： 下列化合物：可用于治疗关节炎，肿瘤转移，组织溃疡，创伤愈合异常，牙周病，骨病，糖尿病（胰岛素抵抗）和HIV感染。
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公开(公告)号：US06716833B2
公开(公告)日：2004-04-06
申请号：US10376871
申请日：2003-02-27
申请人： Jeremy I. Levin , James M. Chen , Derek C. Cole , Mila T. Du , Leif M. Laakso
发明人： Jeremy I. Levin , James M. Chen , Derek C. Cole , Mila T. Du , Leif M. Laakso
IPC分类号： A61K3133
CPC分类号： C07C311/29 , A61K31/5375 , A61K31/54 , C07C2601/04 , C07D213/68 , C07D279/10 , C07D279/12 , C07D309/12 , C07F9/36
摘要： Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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9.发明授权Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors 失效含有异羟肟酸化合物的炔基作为基质金属蛋白酶和抑制剂公开(公告)号：US06340691B1
公开(公告)日：2002-01-22
申请号：US09492977
申请日：2000-01-27
申请人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
发明人： Jeremy I. Levin , Aranapakam M. Venkatesan , Derek C. Cole , James M. Chen , Jamie M. Davis , George T. Grosu
IPC分类号： C07D21140
CPC分类号： C07D209/48 , C07C317/44 , C07C317/50 , C07C323/60 , C07C2601/14 , C07D207/34 , C07D213/56 , C07D215/48 , C07D215/54 , C07D217/26 , C07D295/088 , C07D309/04 , C07D311/84 , C07D333/20 , C07D333/60 , C07D335/02
摘要： Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 该化合物可用于治疗由TNF-α介导的疾病状况，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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10.发明授权Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors 失效乙酰芳基磺酰胺和次膦酸酰胺异羟肟酸TACE抑制剂公开(公告)号：US06277885B1
公开(公告)日：2001-08-21
申请号：US09491636
申请日：2000-01-27
申请人： Jeremy I. Levin , James M. Chen
发明人： Jeremy I. Levin , James M. Chen
IPC分类号： A61K31185
CPC分类号： C07D405/12 , A61K31/5375 , A61K31/54 , C07C311/29 , C07C2601/04 , C07D213/68 , C07D309/12 , C07F9/36
摘要： Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
摘要翻译： 具有该化学式的羟肟酸可用于治疗由TNF-α介导的疾病状态，例如类风湿性关节炎，骨关节炎，败血症，AIDS，溃疡性结肠炎，多发性硬化，克罗恩病和退行性软骨损失。
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