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公开(公告)号:US07645747B2
公开(公告)日:2010-01-12
申请号:US11258621
申请日:2005-10-25
申请人: Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人: Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号: A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28
CPC分类号: C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译: 本发明涉及磷取代的治疗剂,含有这种磷取代剂的组合物,以及包括施用这种磷取代剂的治疗方法,以及可用于制备这种药剂的方法和中间体。
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公开(公告)号:US20090306112A1
公开(公告)日:2009-12-10
申请号:US12307674
申请日:2007-07-19
申请人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号: A61K31/505 , C07D405/02 , A61K31/443 , C12N5/00 , C12N7/04 , C07D405/14 , C07D215/38 , A61K31/47 , C07D417/02 , A61K31/4439 , C07D213/02 , A61K31/44 , C07D239/02 , C07D249/08 , A61K31/4196 , C07D257/04 , A61K31/41 , C07D277/22 , A61K31/426
CPC分类号: C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐,溶剂化物,酯和/或膦酸酯,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法。
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公开(公告)号:US20090227543A1
公开(公告)日:2009-09-10
申请号:US12166145
申请日:2008-07-01
申请人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
发明人: Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan
IPC分类号: A61K31/665 , C07F9/655
CPC分类号: A61K47/548 , A61K47/542
摘要: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有免疫调节活性的膦酸酯取代的化合物,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US20090131372A1
公开(公告)日:2009-05-21
申请号:US12145329
申请日:2008-06-24
申请人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
发明人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
IPC分类号: A61K31/675 , C07F9/38 , A61P3/00
CPC分类号: A61K31/66 , A61K31/675 , A61K47/548
摘要: The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有用于治疗代谢性疾病和/或病症(例如糖尿病和高胆固醇血症)的活性的磷取代的化合物,以及含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于 制备此类化合物。
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公开(公告)号:US20090105279A1
公开(公告)日:2009-04-23
申请号:US11880069
申请日:2007-07-19
申请人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号: C07D401/00 , C07D211/00 , A61K31/4427 , C07D405/00 , C07D215/38 , C07D249/08 , A61K31/4196 , C07D277/30 , C07D493/04 , C07F9/547 , C12N7/06 , A61K31/34 , C07D257/04 , A61K31/41 , C07D239/02 , A61K31/4709 , C07D417/00 , C07D409/00
CPC分类号: C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐,溶剂合物,酯和/或膦酸盐,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法。
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公开(公告)号:US20090029939A1
公开(公告)日:2009-01-29
申请号:US11807303
申请日:2007-05-25
申请人: James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
发明人: James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
IPC分类号: A61K31/7072 , C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/496 , A61P31/18 , A61K31/675 , C07F9/58 , C12N5/06 , C07D487/04
CPC分类号: C07D207/404 , C07D471/04 , C07D487/04
摘要: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl, Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译: 公开了根据以下结构的三环化合物,其受保护的中间体和用于抑制HIV整合酶的方法。 A1和A2是形成五,六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O,S或取代的氮。 Ar是芳基或杂芳基,Q是N,+ NR或CR 4。 芳基碳可以独立地被除氢以外的取代基取代。 化合物可以包括共价连接在任何位点的前药部分。
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公开(公告)号:US20090011927A1
公开(公告)日:2009-01-08
申请号:US12208569
申请日:2008-09-11
IPC分类号: B01J29/072
CPC分类号: B01D53/8625 , B01D2257/402 , Y02C20/10
摘要: A gas stream containing nitrous oxide and ammonia is contacted with a catalyst composition containing a zeolite. N2O is reduced to N2 and H2O at low temperatures in a highly efficient manner. Ammonia-mediated reduction of nitrous oxide can be effectuated from gas streams having N2O concentrations as low as 1%. The gas stream may also contact a catalytic composition selective for the reduction of NOx. In this way, N2O and NOx treatment may be effectuated in a single process stream.
摘要翻译: 含有一氧化二氮和氨的气流与含有沸石的催化剂组合物接触。 N2O在低温下以高效率的方式还原成N2和H2O。 氨介导的一氧化二氮的还原可以从具有低至1%的N 2 O浓度的气流中实现。 气流还可以选择性地接触用于还原NOx的催化剂组合物。 以这种方式,N2O和NOx处理可以在单个工艺流中实现。
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公开(公告)号:US07429565B2
公开(公告)日:2008-09-30
申请号:US10832815
申请日:2004-04-26
申请人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人: Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号: A61K38/00 , C07D267/22
CPC分类号: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有抗病毒活性的磷取代的化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US07407965B2
公开(公告)日:2008-08-05
申请号:US10832817
申请日:2004-04-26
申请人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
发明人: James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins
IPC分类号: A61K31/505 , C07F9/02
CPC分类号: A61K31/66 , A61K31/675 , A61K47/548
摘要: The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及具有用于治疗代谢性疾病和/或病症(例如糖尿病和高胆固醇血症)的活性的磷取代的化合物,以及含有这些化合物的组合物,以及包括施用这些化合物的治疗方法以及可用于 制备此类化合物。
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10.
公开(公告)号:US07182927B2
公开(公告)日:2007-02-27
申请号:US11039228
申请日:2005-01-19
申请人: Pascaline H. Tran , Xinsheng Liu , James M. Chen
发明人: Pascaline H. Tran , Xinsheng Liu , James M. Chen
IPC分类号: B01D53/54
CPC分类号: B01J29/7615 , B01D53/8628 , B01J29/072 , B01J29/7057 , B01J35/002 , B01J2229/18 , B01J2229/24
摘要: The present invention is directed to an iron-promoted zeolite beta catalyst useful in the selective catalytic reduction of nitrogen oxides with ammonia in which the iron-promoted zeolite beta is treated so as to provide increased amounts of the iron promoter in the form of Fe(OH).The stabilized zeolite is formed by cation exchange of an iron salt into a zeolite beta which has a reduced sodium content such as by exchanging a sodium beta with ammonium or hydrogen cations. A zeolite beta having a reduced carbon content and a Si/Al ratio of no more than 10 also increases the Fe(OH) content of the iron-promoted catalyst. The iron-promoted catalyst which has the iron in the form of Fe(OH) is characterized by a peak at 3680±5 cm−1 in the IR spectra.
摘要翻译: 本发明涉及可用于用氨选择性催化还原氮氧化物的铁促进的沸石β催化剂,其中处理铁促进沸石β以提供增加量的铁形式的铁促进剂(Fe 哦)。 稳定的沸石通过将铁盐阳离子交换成沸石β形成,沸石β具有降低的钠含量,例如通过用铵或氢阳离子交换钠β。 具有降低的碳含量和不超过10的Si / Al比的沸石β也增加了铁促进的催化剂的Fe(OH)含量。 具有Fe(OH)形式的铁的铁促进催化剂的特征在于IR光谱中在3680±5cm -1的峰。
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