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公开(公告)号：US20050191281A1
公开(公告)日：2005-09-01
申请号：US11049291
申请日：2005-02-03
IPC分类号： C12N5/06 , A61F2/04 , A61F2/06 , A61F2/10 , A61L27/00 , A61L27/36 , A61L27/38 , A61L31/00 , A61K45/00 , A01N1/02 , C12N5/08
CPC分类号： A61L31/005 , A61F2/04 , A61F2/06 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.
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公开(公告)号：US08855343B2
公开(公告)日：2014-10-07
申请号：US12323505
申请日：2008-11-26
申请人： John Usher , Steven Goldstein
发明人： John Usher , Steven Goldstein
摘要： An earpiece and method to control a level of audio reproduction within an occluded ear canal are provided. The method includes the steps of measuring an ambient sound level from an Ambient Sound Microphone (ASM) at an entrance to an occluded ear canal, measuring a residual background noise level within an occluded ear canal from an Ear Canal Microphone (ECM), measuring a level of audio content delivered to the occluded ear canal, and adjusting a gain of the audio content so as to maintain reproduction of the audio content within a predetermined level range.
摘要翻译： 提供了一种用于控制闭塞耳道内的音频再现水平的听筒和方法。 该方法包括以下步骤：在耳塞入口处测量来自环境声音麦克风（ASM）的环境声级，测量来自耳道麦克风（ECM）的闭塞耳道内的残留背景噪声水平，测量 传送到闭塞的耳道的音频内容的级别，以及调整音频内容的增益，以便将音频内容的再现保持在预定的电平范围内。
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公开(公告)号：US20120009644A1
公开(公告)日：2012-01-12
申请号：US12831057
申请日：2010-07-06
申请人： Joseph Hamby , Steven Walsh , Al Heacox , Steven Goldstein , David Gale , Stacy Arnold , Ann Sands Updegrove
发明人： Joseph Hamby , Steven Walsh , Al Heacox , Steven Goldstein , David Gale , Stacy Arnold , Ann Sands Updegrove
CPC分类号： A61L27/3687 , A61K35/44 , A61L27/3691
摘要： A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material with water or a hypotonic solution to lyse native cells of the tissue material, treating the tissue material in a nuclease-containing solution which includes an antimicrobial, treating the tissue material with an alkaline alcohol solution, treating the tissue material with a chlorine dioxide treatment solution, and sterilizing the tissue material.
摘要翻译： 提供了一种用于制备用于植入的组织植入物的方法。 该方法包括从人或动物供体收集组织材料，用水或低渗溶液处理组织材料以溶解组织材料的天然细胞，在含核酸酶的溶液中处理组织物质，其包括抗微生物剂，治疗 所述组织材料用碱性醇溶液处理，用二氧化氯处理溶液处理组织材料，并对组织材料进行灭菌。
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4.发明申请公开(公告)号：US20090240497A1
公开(公告)日：2009-09-24
申请号：US12343277
申请日：2008-12-23
申请人： John Usher , Steven Goldstein , Marc Boillot , Gary Hoshizaki
发明人： John Usher , Steven Goldstein , Marc Boillot , Gary Hoshizaki
摘要： A method for an earpiece to manage a delivery of a message can include receiving a notice that a message is available at a communication device, parsing the notice for header information that identifies at least a portion of the message, and requesting a subsequent delivery of at least a portion of the message from the communication device if at least one keyword in the header information is in an acceptance list. Other embodiments are disclosed.
摘要翻译： 一种用于管理消息传送的耳机的方法可以包括：在通信设备处接收消息可用的通知，解析用于识别消息的至少一部分的头信息的通知，并请求随后的传送 如果标题信息中的至少一个关键字在接受列表中，则来自通信设备的消息的最少一部分。 公开了其他实施例。
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公开(公告)号：US20080046246A1
公开(公告)日：2008-02-21
申请号：US11839991
申请日：2007-08-16
申请人： Steven Goldstein , John Usher , John Keady
发明人： Steven Goldstein , John Usher , John Keady
IPC分类号： G10L13/00
CPC分类号： H04S1/005 , G10L21/0264 , H04R2420/07 , H04R2499/11 , H04S2420/01
摘要： At least one exemplary embodiment is directed to a method of auditory communication comprising: measuring a data set; identifying the type of data set; obtaining the auditory cue associated with the type of data set; and generating an auditory notification; and emitting the auditory notification.
摘要翻译： 至少一个示例性实施例涉及一种听觉通信的方法，包括：测量数据集; 识别数据集的类型; 获取与数据集类型相关的听觉提示; 并产生听觉通知; 并发出听觉通知。
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公开(公告)号：US20060247634A1
公开(公告)日：2006-11-02
申请号：US11308767
申请日：2006-05-01
申请人： Kenneth Warner , Steven Goldstein
发明人： Kenneth Warner , Steven Goldstein
IPC分类号： A61F2/30
CPC分类号： A61B17/7062
摘要： A spinous process spacer implant for relief of back pain is disclosed. The implant, a generally H-shaped device having grooved ends, is made of human allograft or other suitable artificial or natural material. It is sized for implantation between and optional attachment to adjacent spinous processes. The implant may be hollow in the center to allow for addition of suitable biological material.
摘要翻译： 公开了用于缓解背痛的棘突间隔植入物。 植入物，具有开槽末端的大体H形装置由人类同种异体移植物或其它合适的人造或天然材料制成。 其尺寸用于在相邻棘突之间进行植入和可选附接。 植入物在中心可以是中空的，以允许添加合适的生物材料。
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公开(公告)号：US20060033292A1
公开(公告)日：2006-02-16
申请号：US11185922
申请日：2005-07-20
申请人： Steven Goldstein , Robert VanZee , Louis Pace
发明人： Steven Goldstein , Robert VanZee , Louis Pace
IPC分类号： F16J15/02
CPC分类号： E05B15/02 , E05B17/00 , E05B63/0043
摘要： A method and apparatus to cover openings in a plurality of materials is described. In one embodiment, a disc shaped member includes a three-stepped surface having an outer, second, and inner surface, is configured to fit into and cover an existing opening. The outer surface is sized larger than the opening being covered. The second surface being sized to fit within such opening. The inner surface being the smallest and includes a blind hole for the insertion of a bolt. The bolt and an inner member cooperate such that the disk shaped member may be lined up with an inside surface of an opening of virtually any material or object configured to accept such a disk shaped member. Once the disk shaped member is fastened onto the exterior surface of a doorframe using a bolt and the inner member, for example, the existing hole being covered will no longer be visible or accessible, thereby beautifying, covering, and securing the object.
摘要翻译： 描述了一种覆盖多种材料中的开口的方法和装置。 在一个实施例中，盘形构件包括具有外表面，第二表面和内表面的三阶表面，被配置成装配并覆盖现有的开口。 外表面的尺寸大于被覆盖的开口。 第二表面的尺寸适合于这样的开口。 内表面最小，包括用于插入螺栓的盲孔。 螺栓和内部构件协调，使得盘形构件可以与构造成接受这种盘形构件的实际上任何材料或物体的开口的内表面对齐。 一旦盘形构件使用螺栓和内部构件紧固在门框的外表面上，例如，被覆盖的现有孔将不再可见或可接近，从而美化，覆盖和固定物体。
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公开(公告)号：US5899937A
公开(公告)日：1999-05-04
申请号：US812303
申请日：1997-03-05
申请人： Steven Goldstein , Kirby S. Black
发明人： Steven Goldstein , Kirby S. Black
CPC分类号： A61F2/2415 , C12M21/08 , C12M29/12 , A61F2/2472
摘要： A closed, sterile pulsatile flow loop for studying tissue valves. The system provides both a tool to examine heart valve leaflet fibroblast function and differentiation as these are affected by mechanical loading, as well as an apparatus to provide heart valves seeded with suitable cells. The sterile pulsatile flow system provides a left heart duplicator, which exposes viable tissue valves to a dynamic flow environment imitating that of the aortic valve.
摘要翻译： 用于研究组织瓣膜的封闭的无菌脉动流动回路。 该系统提供了检查心脏瓣膜成纤维细胞功能和分化的工具，因为它们受到机械负荷的影响，以及提供合适细胞的心脏瓣膜的装置。 无菌脉动流系统提供左心脏复制器，其将活组织瓣膜暴露于模拟主动脉瓣的动态流动环境。
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公开(公告)号：US5632778A
公开(公告)日：1997-05-27
申请号：US463643
申请日：1995-06-05
申请人： Steven Goldstein
发明人： Steven Goldstein
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/3625 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/3895 , A61L2430/40 , Y10S623/92 , Y10S623/921
摘要： This disclosure includes a method for generating a functional hybrid bioprosthesis. Tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules. Then it may be treated sequentially with extracellular matrix adhesion factor, extracellular matrix glycosaminoglycan, and growth factor appropriate to the cell type required to function within the matrix, and incubating the transplant tissue matrix with cells that are either allogeneic or autologous for the recipient thereby imparting to the matrix the characteristics of the cell type and tissue selected. Tissues with a variety of functional bioactivities can thus be formed in vitro prior to graft transplantation or implantation which will exhibit reduced or no stimulation of an immunological response in the recipient.
摘要翻译： 本公开包括用于产生功能性混合生物假体的方法。 处理由间质胶原天然形成的组织以杀死天然细胞并去除潜在的免疫活性可溶性分子。 然后可以依次用细胞外基质粘附因子，细胞外基质糖胺聚糖和适合于在基质内起作用的细胞类型的生长因子进行治疗，并将移植组织基质与同种异体或自体的细胞孵育给接受者，从而赋予 对基质的细胞类型和组织的特征进行选择。 因此，可以在移植物移植或植入之前体外形成具有多种功能生物活性的组织，这将在受体中表现出减少或不刺激免疫应答。
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10.发明授权Method of preparing transplant tissue to reduce immunogenicity upon implantation 失效准备移植组织以减少植入时免疫原性的方法
公开(公告)号：US5613982A
公开(公告)日：1997-03-25
申请号：US463455
申请日：1995-06-05
申请人： Steven Goldstein
发明人： Steven Goldstein
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/3625 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/3895 , A61L2430/40 , Y10S623/92 , Y10S623/921
摘要： This disclosure includes a method for generating a functional hybrid bioprosthesis. Tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules. Then it may be treated sequentially with extracellular matrix adhesion factor such as fibronectin, extracellular matrix glycosaminoglycan such as heparin, and growth factor appropriate to the cell type required to function within the matrix, and incubating the transplant tissue matrix with cells that are either allogeneic or autologous for the recipient thereby imparting to the matrix the characteristics of the cell type and tissue selected. Tissues with a variety of functional bioactivities can thus be formed in vitro prior to graft transplantation or implantation which will exhibit reduced or no stimulation of an immunological response in the recipient.
摘要翻译： 本公开包括用于产生功能性混合生物假体的方法。 处理由间质胶原天然形成的组织以杀死天然细胞并去除潜在的免疫活性可溶性分子。 然后可以依次用细胞外基质粘附因子如纤连蛋白，细胞外基质糖胺聚糖如肝素和与基质中所需的细胞类型相适应的生长因子进行治疗，并将移植组织基质与同种异体或 对于接受者而言是自体的，从而赋予基质所选择的细胞类型和组织的特征。 因此，可以在移植物移植或植入之前体外形成具有多种功能生物活性的组织，这将在受体中表现出减少或不刺激免疫应答。
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