公开(公告)号：US20100324328A1

公开(公告)日：2010-12-23

申请号：US12666101

申请日：2008-06-25

Applicant: Jeremy Stephen Parker ,  Evan William Snape

Inventor： Jeremy Stephen Parker ,  Evan William Snape

IPC: C07C67/58

CPC classification number: C07C319/20 ,  C07C319/28 ,  C07C323/20

Abstract: A process for isolating a compound of formula (I) or a salt thereof, where X and R1 are as defined in the specification, from a mixture containing it, and the corresponding diacid and dihydroxy derivative, said process comprising (i) adding to an organic solution containing said compounds, water and a one or more salts, all of which are bases selected from a carbonate or hydrogen carbonate base, (ii) separating the aqueous phase containing the compound of formula (II) from the organic phase containing the compounds of formula (I) and (III); then (iii) recovering the compound of formula (I) from remaining organic phase. The process provides for efficient isolation of the target compound, even on a large scale.

Abstract translation: 一种分离式（I）化合物或其盐的方法，其中X和R 1如说明书中所定义，含有它的混合物和相应的二酸和二羟基衍生物，所述方法包括（i）加入到 含有所述化合物的有机溶液，水和一种或多种盐，其全部为选自碳酸盐或碳酸氢盐碱的碱，（ii）将含有式（II）化合物的水相与含有化合物的有机相分离 的式（I）和（III）; 然后（iii）从剩余的有机相中回收式（I）化合物。 该方法即使在大规模的情况下也能有效地分离目标化合物。

公开(公告)号：US07700640B2

公开(公告)日：2010-04-20

申请号：US11665247

申请日：2005-10-11

Applicant: Philip Cornwall ,  David Simon Ennis ,  Melvyn Edward Giles ,  Jacob Robert James Perkins ,  Shelly Louise Jenkin ,  Jeremy Stephen Parker ,  Bharti Patel

Inventor： Philip Cornwall ,  David Simon Ennis ,  Melvyn Edward Giles ,  Jacob Robert James Perkins ,  Shelly Louise Jenkin ,  Jeremy Stephen Parker ,  Bharti Patel

IPC: A61K31/415 ,  C07D231/38

CPC classification number: C07D231/40 ,  C07C255/54 ,  C07C317/22 ,  C07D213/80

Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract translation: 一种制备式（I）化合物的方法，所述方法包括a）使式（II）的化合物与以下物质反应：i）通过X2的亲核芳族取代的式（III）化合物和ii）式 IV），例如通过亲核芳族取代b）如果需要，将X 1转化成羧酸; 和c）羧酸基团与适当杂环胺的偶联; 其中所有变量如说明书中所定义。

公开(公告)号：US07411074B2

公开(公告)日：2008-08-12

申请号：US10528974

申请日：2003-09-29

Applicant: Paul Murray ,  Jeremy Stephen Parker ,  Paul Schofield ,  Andrew Stocker

Inventor： Paul Murray ,  Jeremy Stephen Parker ,  Paul Schofield ,  Andrew Stocker

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D333/36 ,  Y02P20/55

Abstract: A process for preparing a compound of formula (I) where R4 and R5 are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4, R5 and R6 are as defined in relation to formula (I), and R7 is nitrogen-protecting group, and removing the group R7—, and thereafter if desired or necessary, removing any protecting group R6 to obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed.

Abstract translation: 制备其中R 4和R 5的式（I）化合物的方法如说明书中所定义; 和R 6是氢或保护基，该方法包括使式（II）的化合物环化，其中R 4，R 5和 R 6如关于式（I）所定义，R 7为氮保护基，除去R 7 - ，然后如果需要或必要的话，除去任何保护基团R 6以获得相应的羧酸。 还描述和要求保护新型中间体和制备药物化合物中产物的用途。

公开(公告)号：US07973178B2

公开(公告)日：2011-07-05

申请号：US12095101

申请日：2006-11-27

Applicant: Phillip Anthony Hopes ,  Jeremy Stephen Parker ,  Bharti Patel ,  Matthew James Welham

Inventor： Phillip Anthony Hopes ,  Jeremy Stephen Parker ,  Bharti Patel ,  Matthew James Welham

IPC: C07D205/00

CPC classification number: C07D403/12 ,  C07D205/04

Abstract: A process for making a compound of formula (I), which is useful as an intermediate to compounds which activate glucokinase, is described, (wherein P1, R1 and R2 are as defined in the description).

Abstract translation: 描述了制备式（I）化合物的方法，其可用作活化葡糖激酶的化合物的中间体，（其中P1，R1和R2如说明书中所定义）。

公开(公告)号：US20080300412A1

公开(公告)日：2008-12-04

申请号：US12095101

申请日：2006-11-27

Applicant: Phillip Anthony Hopes ,  Jeremy Stephen Parker ,  Bhari Patel ,  Matthew James Welham

Inventor： Phillip Anthony Hopes ,  Jeremy Stephen Parker ,  Bhari Patel ,  Matthew James Welham

IPC: C07D403/12 ,  C07D205/04

CPC classification number: C07D403/12 ,  C07D205/04

Abstract: A process for making a compound of formula (I), which is useful as an intermediate to compounds which activate glucokinase, is described, (wherein P1, R1 and R2 are as defined in the description).

Abstract translation: 描述了制备式（I）化合物的方法，其可用作活化葡糖激酶的化合物的中间体，（其中P1，R1和R2如说明书中所定义）。

公开(公告)号：US20080200694A1

公开(公告)日：2008-08-21

申请号：US11665247

申请日：2005-10-11

Applicant: Philip Cornwall ,  David Simon Ennis ,  Melvyn Edward Giles ,  Jacob Robert James Perkins ,  Shelly Louise Jenkin ,  Jeremy Stephen Parker ,  Bharti Patel

Inventor： Philip Cornwall ,  David Simon Ennis ,  Melvyn Edward Giles ,  Jacob Robert James Perkins ,  Shelly Louise Jenkin ,  Jeremy Stephen Parker ,  Bharti Patel

IPC: C07D231/10

CPC classification number: C07D231/40 ,  C07C255/54 ,  C07C317/22 ,  C07D213/80

Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract translation: 一种制备式（I）化合物的方法，所述方法包括a）使式（II）化合物与以下物质反应：i）式（III）化合物通过X 2的亲核芳族取代， 和ii）式（IV）化合物，例如通过亲核芳族取代b）在必要时将X 1转化为羧酸; 和c）羧酸基团与适当杂环胺的偶联; 其中所有变量如说明书中所定义。