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公开(公告)号：US20080119658A1
公开(公告)日：2008-05-22
申请号：US11933036
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： C07D249/16 , C07D207/30
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于HDAC，其包含选自以下的化合物：其中取代基如本文所定义。
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公开(公告)号：US20090111996A1
公开(公告)日：2009-04-30
申请号：US11932860
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： C07D403/02 , C07D249/16
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于HDAC，其包含选自以下的化合物：其中取代基如本文所定义。
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公开(公告)号：US07741494B2
公开(公告)日：2010-06-22
申请号：US11932860
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： C07D231/56 , A01N43/56
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于HDAC，其包含选自以下的化合物：其中取代基如本文所定义。
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公开(公告)号：US20080119648A1
公开(公告)日：2008-05-22
申请号：US11932995
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： C07D231/56 , C07D413/02 , C07D401/02 , C07D471/04 , C07D249/16 , C07D403/02 , C07D209/00
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
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公开(公告)号：US20080114037A1
公开(公告)日：2008-05-15
申请号：US11932727
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： A61K31/4192 , A61K31/415 , A61K31/40 , C07D249/16 , C07D207/30
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
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公开(公告)号：US20090105485A1
公开(公告)日：2009-04-23
申请号：US11932308
申请日：2007-10-31
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： C07D403/02 , C07D249/16
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
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公开(公告)号：US07732475B2
公开(公告)日：2010-06-08
申请号：US11457260
申请日：2006-07-13
申请人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
发明人： Jerome C. Bressi , Anthony R. Gangloff , Lily Kwok
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/12 , C07D209/18 , C07D209/44 , C07D231/14 , C07D231/20 , C07D231/38 , C07D231/56 , C07D249/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D471/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
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公开(公告)号：US08178534B2
公开(公告)日：2012-05-15
申请号：US12541724
申请日：2009-08-14
申请人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D Lawson , Jeffrey A Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
发明人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D Lawson , Jeffrey A Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
IPC分类号： A61K31/50 , A61K31/495 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译： 提供以下配方的化合物与cMET一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。
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公开(公告)号：US20100093767A1
公开(公告)日：2010-04-15
申请号：US11720184
申请日：2005-12-02
申请人： Jerome C. Bressi , Andrew John Jennings , Stephen W. Kaldor , Lily Kwok , Clifford D. Mol , Jeffrey A. Stafford
发明人： Jerome C. Bressi , Andrew John Jennings , Stephen W. Kaldor , Lily Kwok , Clifford D. Mol , Jeffrey A. Stafford
IPC分类号： C07D235/16 , A61K31/4184 , A61K31/4439 , C07D401/12 , C07D471/04 , A61K31/437 , A61K31/52 , C07D473/00 , C12N9/99 , A61P35/04 , A61P9/00 , A61P37/00 , A61P29/00
CPC分类号： C07D471/04 , C07D235/14 , C07D401/06 , C07D409/06 , C07D409/12 , C07D487/04
摘要： The invention relates to inhibitors of enzymes that disrupt the assembly and function of the mitotic spindle, compositions comprising the inhibitors of Formula (I), kits and articles of manufacture comprising the inhibitors and inhibitor compositions, and methods of using the inhibitors and inhibitor compositions. The inhibitors and inhibitor compositions are useful for treating, preventing or modulating diseases in which mitotic kinesins, including kinesin-like spindle protein (KSP), may be involved; symptoms of such diseases; or the effect of other physiological events mediated by mitotic kinesins, including KSP.
摘要翻译： 本发明涉及破坏有丝分裂纺锤体的组装和功能的酶抑制剂，包含式（I）抑制剂的组合物，包含抑制剂和抑制剂组合物的试剂盒和制品，以及使用抑制剂和抑制剂组合物的方法。 抑制剂和抑制剂组合物可用于治疗，预防或调节可能涉及丝裂原驱动蛋白（包括驱动蛋白样纺锤蛋白（KSP））的疾病; 这种疾病的症状; 或由有丝分裂驱动蛋白（包括KSP）介导的其他生理事件的影响。
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公开(公告)号：US20100063054A1
公开(公告)日：2010-03-11
申请号：US12541724
申请日：2009-08-14
申请人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D. Lawson , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
发明人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D. Lawson , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
IPC分类号： A61K31/5025 , C07D487/04 , A61P35/04 , A61P11/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供以下配方的化合物与cMET一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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