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公开(公告)号:US20100093767A1
公开(公告)日:2010-04-15
申请号:US11720184
申请日:2005-12-02
申请人: Jerome C. Bressi , Andrew John Jennings , Stephen W. Kaldor , Lily Kwok , Clifford D. Mol , Jeffrey A. Stafford
发明人: Jerome C. Bressi , Andrew John Jennings , Stephen W. Kaldor , Lily Kwok , Clifford D. Mol , Jeffrey A. Stafford
IPC分类号: C07D235/16 , A61K31/4184 , A61K31/4439 , C07D401/12 , C07D471/04 , A61K31/437 , A61K31/52 , C07D473/00 , C12N9/99 , A61P35/04 , A61P9/00 , A61P37/00 , A61P29/00
CPC分类号: C07D471/04 , C07D235/14 , C07D401/06 , C07D409/06 , C07D409/12 , C07D487/04
摘要: The invention relates to inhibitors of enzymes that disrupt the assembly and function of the mitotic spindle, compositions comprising the inhibitors of Formula (I), kits and articles of manufacture comprising the inhibitors and inhibitor compositions, and methods of using the inhibitors and inhibitor compositions. The inhibitors and inhibitor compositions are useful for treating, preventing or modulating diseases in which mitotic kinesins, including kinesin-like spindle protein (KSP), may be involved; symptoms of such diseases; or the effect of other physiological events mediated by mitotic kinesins, including KSP.
摘要翻译: 本发明涉及破坏有丝分裂纺锤体的组装和功能的酶抑制剂,包含式(I)抑制剂的组合物,包含抑制剂和抑制剂组合物的试剂盒和制品,以及使用抑制剂和抑制剂组合物的方法。 抑制剂和抑制剂组合物可用于治疗,预防或调节可能涉及丝裂原驱动蛋白(包括驱动蛋白样纺锤蛋白(KSP))的疾病; 这种疾病的症状; 或由有丝分裂驱动蛋白(包括KSP)介导的其他生理事件的影响。
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公开(公告)号:US07642275B2
公开(公告)日:2010-01-05
申请号:US11303455
申请日:2005-12-16
申请人: Jerome C. Bressi , Jason W. Brown , Robert J. Skene , Jeffrey A. Stafford , Phong H. Vu , Anthony R. Gangloff , Andrew J. Jennings , Stephen W. Kaldor
发明人: Jerome C. Bressi , Jason W. Brown , Robert J. Skene , Jeffrey A. Stafford , Phong H. Vu , Anthony R. Gangloff , Andrew J. Jennings , Stephen W. Kaldor
IPC分类号: A61K31/423 , A61K31/428 , A61K31/416 , C07D265/12 , C07D277/68 , C07D235/26
CPC分类号: C07D235/06 , C07D235/26 , C07D263/38 , C07D263/58 , C07D277/68 , C07D277/72 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于组蛋白脱乙酰酶(HDAC),组蛋白脱乙酰酶包含下式化合物:其中变量如本文所定义。
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公开(公告)号:US20090291938A1
公开(公告)日:2009-11-26
申请号:US12274213
申请日:2008-11-19
申请人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号: A61K31/551 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US07687625B2
公开(公告)日:2010-03-30
申请号:US10809637
申请日:2004-03-24
申请人: Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号: C07D285/16 , A61K31/5395
CPC分类号: C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译: 提供化合物,药物,试剂盒和方法用于DPP-IV和其它包含下式的化合物的S9蛋白酶:其中Q选自CO,SO,SO 2或C = NR 9; 并且R 1,R 2,R 3和R 4如本文所定义。
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公开(公告)号:US20110201818A1
公开(公告)日:2011-08-18
申请号:US12680183
申请日:2008-09-24
申请人: Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人: Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号: C07D211/72
CPC分类号: C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US07790736B2
公开(公告)日:2010-09-07
申请号:US10918317
申请日:2004-08-12
申请人: Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人: Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号: C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , A61K31/506 , A61P19/02
CPC分类号: C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号:US20100075973A1
公开(公告)日:2010-03-25
申请号:US12544419
申请日:2009-08-20
申请人: Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
IPC分类号: A61K31/5025 , C07D471/14 , A61P35/00
CPC分类号: C07D487/14
摘要: The present invention provides PLK inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译: 本发明提供下式的PLK抑制剂,其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。
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公开(公告)号:US20080312307A1
公开(公告)日:2008-12-18
申请号:US12126772
申请日:2008-05-23
IPC分类号: A61K31/403 , C07D209/02 , A61P11/00 , A61P13/12 , A61P29/00 , A61P35/00 , C07D209/52
CPC分类号: C07D209/42 , C07D209/52
摘要: Compounds are provided for inhibition of MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供化合物用于抑制MEK,其包含:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08138168B1
公开(公告)日:2012-03-20
申请号:US12239538
申请日:2008-09-26
申请人: Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
发明人: Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
IPC分类号: A61K31/407 , A61K31/4745 , A61K31/4178 , C07D453/02
CPC分类号: C07D235/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要: The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
摘要翻译: 本发明涉及具有下式的化合物:其中变量如本文所定义。 本发明还涉及制备和使用这些化合物的方法,药物组合物,试剂盒和制品包含这些化合物。
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公开(公告)号:US20090281092A1
公开(公告)日:2009-11-12
申请号:US12237306
申请日:2008-09-24
申请人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号: A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号: C07D487/04 , C07D487/14 , C07D519/00
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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