利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

124 条记录 (耗时 0.073 秒)

    Death domain containing receptor 5
    2.
    发明授权
    Death domain containing receptor 5 失效
    含有受体5的死亡域

    公开(公告)号：US07803615B1

    公开(公告)日：2010-09-28

    申请号：US09042583

    申请日：1998-03-17

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Jeffrey Y. Su ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Jeffrey Y. Su ,  Craig A. Rosen

    IPC分类号： C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

    Human Tumor Necrosis Factor Receptor-Like 2
    4.
    发明申请
    Human Tumor Necrosis Factor Receptor-Like 2 有权

    公开(公告)号：US20090092608A1

    公开(公告)日：2009-04-09

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/395 ,  C12N15/11 ,  C07K14/00 ,  C07K16/18

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    Metalloproteinases
    5.
    发明授权
    Metalloproteinases 失效
    金属蛋白酶

    公开(公告)号：US07169566B2

    公开(公告)日：2007-01-30

    申请号：US10979092

    申请日：2004-11-02

    申请人： Jian Ni ,  Steven M. Ruben ,  Laurie A. Brewer ,  Reiner L. Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Steven M. Ruben ,  Laurie A. Brewer ,  Reiner L. Gentz ,  Craig A. Rosen

    IPC分类号： G01N33/53 ,  C12N5/06 ,  C12N5/16 ,  C12P21/08 ,  C07K16/00

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Polynucleotides encoding human tumor necrosis factor receptor-like2
    9.
    发明授权
    Polynucleotides encoding human tumor necrosis factor receptor-like2 失效
    编码人肿瘤坏死因子受体的多核苷酸2

    公开(公告)号：US07427492B1

    公开(公告)日：2008-09-23

    申请号：US08741095

    申请日：1996-10-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/64 ,  C12N15/09 ,  C12N5/16 ,  C12N5/10 ,  C12N1/11 ,  C12N1/15 ,  C12N1/21

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。