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16 条记录 (耗时 0.039 秒)

    Polynucleotide encoding a histamine receptor
    3.
    发明授权
    Polynucleotide encoding a histamine receptor 有权
    编码组胺受体的多核苷酸

    公开(公告)号：US06204017B1

    公开(公告)日：2001-03-20

    申请号：US09414010

    申请日：1999-10-07

    申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

    发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

    IPC分类号： C12N1512

    CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

    摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

    摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

    Histamine receptor antibody
    4.
    发明授权
    Histamine receptor antibody 有权
    组胺受体抗体

    公开(公告)号：US07166705B2

    公开(公告)日：2007-01-23

    申请号：US10616088

    申请日：2003-07-08

    申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

    发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

    IPC分类号： C07K16/28

    CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

    摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

    摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

    Modulators of the orphan G protein-coupled receptors GPR78 and GPR26
    5.
    发明授权
    Modulators of the orphan G protein-coupled receptors GPR78 and GPR26 失效
    孤儿G蛋白偶联受体GPR78和GPR26的调节剂

    公开(公告)号：US07872101B1

    公开(公告)日：2011-01-18

    申请号：US11949306

    申请日：2007-12-03

    申请人： Suke Wang ,  Frederick James Monsma, Jr. ,  Xiaoxin Yang ,  Eric L. Gustafson ,  Maureen Laverty ,  Elizabeth B. Smith

    发明人： Suke Wang ,  Frederick James Monsma, Jr. ,  Xiaoxin Yang ,  Eric L. Gustafson ,  Maureen Laverty ,  Elizabeth B. Smith

    IPC分类号： C07K14/00

    CPC分类号： C07K14/723

    摘要： The invention relates to the use of the interaction between the GPR78 polypeptide or the GPR26 polypeptide and their identified ligands and antagonists as the basis for screening methods for the identification of agents that modulate the activity of these receptors, and for diagnostic and therapeutic purposes. The agents identified by the screening methods of the invention have use in the treatment of GPR78- and/or GPR26-mediated disorders, including, but not limited to, neurological disorders (such as anxiety disorders), metabolic disorders, cardiovascular disorders, hormone-related disorders, vascular disorders and hyperproliferative disorders (such as cancer).

    摘要翻译： 本发明涉及GPR78多肽或GPR26多肽及其鉴定的配体和拮抗剂之间的相互作用的用途，作为筛选调节这些受体活性的试剂的筛选方法以及用于诊断和治疗目的的基础。 通过本发明的筛选方法鉴定的药物可用于治疗GPR78和/或GPR26介导的病症，包括但不限于神经系统疾病（例如焦虑症），代谢障碍，心血管疾病，激素 - 相关疾病，血管疾病和过度增殖性疾病（例如癌症）。

    Leukotriene receptor
    6.
    发明授权
    Leukotriene receptor 失效
    白三烯受体

    公开(公告)号：US06939953B2

    公开(公告)日：2005-09-06

    申请号：US10104340

    申请日：2002-03-22

    申请人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

    发明人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

    IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/567

    CPC分类号： C07K14/705

    摘要： The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

    摘要翻译： 本发明提供分离的哺乳动物白三烯受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供与受体特异性结合并可用于治疗由白三烯引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物白三烯受体的特异性激动剂和拮抗剂的筛选方法。

    Leukotriene receptor
    7.
    发明授权
    Leukotriene receptor 失效

    公开(公告)号：US06465212B1

    公开(公告)日：2002-10-15

    申请号：US09400622

    申请日：1999-09-20

    申请人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

    发明人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

    IPC分类号： C12N1512

    CPC分类号： C07K14/705

    摘要： The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

    HISTAMINE RECEPTOR
    8.
    发明申请
    HISTAMINE RECEPTOR 失效
    组胺受体

    公开(公告)号：US20070117155A1

    公开(公告)日：2007-05-24

    申请号：US11620337

    申请日：2007-01-05

    申请人： Jiang Behan ,  Joseph Hedrick ,  Thomas Laz ,  Frederick Monsma ,  Kelley Morse ,  Shelby Umland ,  Suke Wang

    发明人： Jiang Behan ,  Joseph Hedrick ,  Thomas Laz ,  Frederick Monsma ,  Kelley Morse ,  Shelby Umland ,  Suke Wang

    IPC分类号： G01N33/53

    CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

    摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

    摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

    Mammalian galanin receptors
    9.
    发明授权
    Mammalian galanin receptors 失效
    哺乳动物甘丙肽受体

    公开(公告)号：US07250163B2

    公开(公告)日：2007-07-31

    申请号：US10946767

    申请日：2004-09-22

    申请人： Marvin Bayne ,  Tanaz Hashemi ,  Chaogang He ,  Suke Wang

    发明人： Marvin Bayne ,  Tanaz Hashemi ,  Chaogang He ,  Suke Wang

    IPC分类号： A61K39/395 ,  C07K14/00

    CPC分类号： C07K14/72 ,  A61K38/00

    摘要： The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptors and are useful for treating medical conditions caused or mediated by galanin. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian GalR3 receptors.

    摘要翻译： 本发明提供分离的哺乳动物GalR3受体，分离的或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由甘丙肽引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物GalR3受体的特异性激动剂和拮抗剂的筛选方法。

    Mammalian galanin receptors
    10.
    发明授权
    Mammalian galanin receptors 失效
    哺乳动物甘丙肽受体

    公开(公告)号：US06693182B1

    公开(公告)日：2004-02-17

    申请号：US08916247

    申请日：1997-08-22

    申请人： Marvin Bayne ,  Tanaz Hashemi ,  Chaogang He ,  Suke Wang

    发明人： Marvin Bayne ,  Tanaz Hashemi ,  Chaogang He ,  Suke Wang

    IPC分类号： C12N1512

    CPC分类号： C07K14/72 ,  A61K38/00

    摘要： The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptors and are useful for treating medical conditions caused or mediated by galanin. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian GalR3 receptors.

    摘要翻译： 本发明提供分离的哺乳动物GalR3受体，分离的或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由甘丙肽引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物GalR3受体的特异性激动剂和拮抗剂的筛选方法。