公开(公告)号：US07547523B2

公开(公告)日：2009-06-16

申请号：US11620337

申请日：2007-01-05

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： G01N33/567 ,  C07K14/705

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

公开(公告)号：US06613533B2

公开(公告)日：2003-09-02

申请号：US09812216

申请日：2001-03-19

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： G01N33566

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

公开(公告)号：US06204017B1

公开(公告)日：2001-03-20

申请号：US09414010

申请日：1999-10-07

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： C12N1512

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

公开(公告)号：US07166705B2

公开(公告)日：2007-01-23

申请号：US10616088

申请日：2003-07-08

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： C07K16/28

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

公开(公告)号：US06939953B2

公开(公告)日：2005-09-06

申请号：US10104340

申请日：2002-03-22

申请人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

发明人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/567

CPC分类号： C07K14/705

摘要： The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

摘要翻译： 本发明提供分离的哺乳动物白三烯受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供与受体特异性结合并可用于治疗由白三烯引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物白三烯受体的特异性激动剂和拮抗剂的筛选方法。

公开(公告)号：US06465212B1

公开(公告)日：2002-10-15

申请号：US09400622

申请日：1999-09-20

申请人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

发明人： Suke Wang ,  Ling Pang ,  Thomas M. Laz

IPC分类号： C12N1512

CPC分类号： C07K14/705

摘要： The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

公开(公告)号：US06221616B1

公开(公告)日：2001-04-24

申请号：US09478601

申请日：2000-01-06

申请人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

发明人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

IPC分类号： G01N3353

CPC分类号： A61M1/3621 ,  C07K14/72

摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

公开(公告)号：US06291195B1

公开(公告)日：2001-09-18

申请号：US09478602

申请日：2000-01-06

申请人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

发明人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

IPC分类号： G01N3353

CPC分类号： A61M1/3621 ,  C07K14/72

摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

公开(公告)号：US06221613B1

公开(公告)日：2001-04-24

申请号：US09224426

申请日：1998-12-31

申请人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

发明人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy E. Wilson

IPC分类号： G01N3353

CPC分类号： A61M1/3621 ,  C07K14/72

摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

摘要翻译： 本发明提供编码人MCH1受体的纯化的人MCH1受体的核酸，纯化的人MCH1受体，包含分离的编码人MCH1受体的核酸的载体，包含该载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针 编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常的方法 与人MCH1受体的活性相关，以及确定化合物与哺乳动物MCH1受体结合的方法。

公开(公告)号：US07393655B2

公开(公告)日：2008-07-01

申请号：US10825581

申请日：2004-04-15

申请人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy F. Wilson

发明人： John A. Salon ,  Thomas M. Laz ,  Raisa Nagorny ,  Amy F. Wilson

IPC分类号： G01N33/53 ,  C12N15/00 ,  C07K14/00

CPC分类号： A61M1/3621 ,  C07K14/72

摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

摘要翻译： 本发明提供编码人MCH1受体的纯化的人MCH1受体的核酸，纯化的人MCH1受体，包含分离的编码人MCH1受体的核酸的载体，包含该载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针 编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常的方法 与人MCH1受体的活性相关，以及确定化合物与哺乳动物MCH1受体结合的方法。