-
公开(公告)号:US20100247562A1
公开(公告)日:2010-09-30
申请号:US12438685
申请日:2007-08-24
申请人: Jianlin Gong , Stuart K Calderwood
发明人: Jianlin Gong , Stuart K Calderwood
IPC分类号: A61K39/385 , C07K14/435 , A61P35/00 , A61K39/00 , A61K38/17
CPC分类号: A61K39/0011 , A61K38/00 , A61K2039/5152 , A61K2039/5154 , A61K2039/6043 , C07K16/18
摘要: The present invention relates, generally, to pharmaceutical compositions comprising Heat Shock Proteins (HSPs) and HSP complexes recovered from heterohybrid cells that are generated from the fusion of a first type of cell (Type I) with a second type of cell (Type II). In further embodiments, the present invention relates to preparing HSPs and/or HSP complexes recovered from heterohybrid, and to methods to treat and/or prevent diseases, such as cancer and infectious diseases by administering a pharmaceutical composition comprising a HSP and/or HSP complex recovered from heterohybrid cells that are generated from the fusion of a first type of cell (Type I) with a second type of cell (Type II).
摘要翻译: 本发明通常涉及包含从第一类型细胞(I型)与第二类型细胞(II型)的融合产生的从异源杂交细胞中回收的热休克蛋白(HSP)和HSP复合物的药物组合物, 。 在进一步的实施方案中,本发明涉及制备从杂合杂交体回收的HSP和/或HSP复合物,以及通过施用包含HSP和/或HSP复合物的药物组合物来治疗和/或预防疾病如癌症和感染性疾病的方法 从由第一类型细胞(I型)与第二类型细胞(II型)的融合产生的杂合杂交细胞中回收。
-
公开(公告)号:US06652848B1
公开(公告)日:2003-11-25
申请号:US09618917
申请日:2000-07-18
申请人: Jianlin Gong , Donald Kufe
发明人: Jianlin Gong , Donald Kufe
IPC分类号: A01N6500
CPC分类号: C12N5/16 , A61K38/00 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N2501/22 , C12N2501/23 , C12N2510/00
摘要: Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic cell hybrids.
摘要翻译: 含有通过树突状细胞和非树突细胞融合形成的融合细胞的免疫刺激组合物,使用这些组合物的方法,以及产生树突状细胞杂交体的方法。
-
公开(公告)号:US07601342B2
公开(公告)日:2009-10-13
申请号:US11657882
申请日:2007-01-24
申请人: Jianlin Gong , Donald Kufe
发明人: Jianlin Gong , Donald Kufe
CPC分类号: C12N5/16 , A61K38/00 , A61K39/0011 , A61K2035/122 , A61K2035/124 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N2501/22 , C12N2501/23 , C12N2510/00 , G01N33/5047
摘要: The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive immunotherapy. The fusions according to the invention can also be used in methods for antigen discovery.
-
公开(公告)号:US20050169898A1
公开(公告)日:2005-08-04
申请号:US11053321
申请日:2005-02-07
申请人: Jianlin Gong , Donald Kufe
发明人: Jianlin Gong , Donald Kufe
CPC分类号: C12N5/16 , A61K38/00 , A61K39/0011 , A61K2035/122 , A61K2035/124 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N2501/22 , C12N2501/23 , C12N2510/00 , G01N33/5047
摘要: The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive immunotherapy. The fusions according to the invention can also be used in methods for antigen discovery.
摘要翻译: 本发明涉及树突状细胞和抗原呈递细胞的融合。 还提供了制造和使用这些细胞融合物的方法,包括过继免疫治疗的方法。 根据本发明的融合体也可用于抗原发现的方法中。
-
公开(公告)号:US20070141704A1
公开(公告)日:2007-06-21
申请号:US11657882
申请日:2007-01-24
申请人: Charles Nicolette , Bruce Roberts , Jianlin Gong , Donald Kufe
发明人: Charles Nicolette , Bruce Roberts , Jianlin Gong , Donald Kufe
CPC分类号: C12N5/16 , A61K38/00 , A61K39/0011 , A61K2035/122 , A61K2035/124 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N2501/22 , C12N2501/23 , C12N2510/00 , G01N33/5047
摘要: The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive immunotherapy. The fusions according to the invention can also be used in methods for antigen discovery.
摘要翻译: 本发明涉及树突状细胞和抗原呈递细胞的融合。 还提供了制造和使用这些细胞融合物的方法,包括过继免疫治疗的方法。 根据本发明的融合体也可用于抗原发现的方法中。
-
-
-
-