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1.发明申请Composition for treating cancer containing n,n-dimethylphytosphingosine 审中-公开用于治疗含有n，n-二甲基苯并孕酮的癌症的组合物公开(公告)号：US20050143346A1
公开(公告)日：2005-06-30
申请号：US10512126
申请日：2003-05-01
申请人： Jin-Hee Choi , Chang-Seo Park , Jin-Wook Kim , Chang-Yeol Park , You-A Hwang , Eun-Ju Kim , Ui-Chan Koh
发明人： Jin-Hee Choi , Chang-Seo Park , Jin-Wook Kim , Chang-Yeol Park , You-A Hwang , Eun-Ju Kim , Ui-Chan Koh
IPC分类号： A61K45/00 , A61K31/133 , A61K45/06 , A61P17/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07C213/02 , C07C213/08 , C07C215/10 , C07F9/02 , A61K31/685
CPC分类号： A61K45/06 , A61K31/133 , C07C213/08 , C07C215/10
摘要： A composition and a kit for treating cancer comprising N,N-dimethylphytosphingosine. The composition represses the activity of sphingosine kinase, and therefore, intercepts various mechanisms which sphingosine kinase induces. For example, the composition blocks the phosphorylation of ceramide and sphingosine, thereby maintaining high concentration of ceramide and sphingosine. The ceramide and sphingosine induce apoptosis in cancer cells. Therefore, the composition according to the present invention induces apoptosis in cancer cells and accordingly kills the cancer cells.
摘要翻译： 用于治疗癌症的组合物和试剂盒，其包含N，N-二甲基苯并卟吩苷。 组合物抑制鞘氨醇激酶的活性，因此拦截鞘氨醇激酶诱导的各种机制。 例如，组合物阻断神经酰胺和鞘氨醇的磷酸化，从而保持高浓度的神经酰胺和鞘氨醇。 神经酰胺和鞘氨醇诱导癌细胞凋亡。 因此，根据本发明的组合物诱导癌细胞凋亡，因此杀死癌细胞。
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2.发明申请Composition for Protection and Improvement of Skin, or Reinforcing Skin Barrier Function Comprising Phosphatidylserine 有权用于保护和改善皮肤或增强包含磷脂酰丝氨酸的皮肤屏障功能的组合物公开(公告)号：US20080193394A1
公开(公告)日：2008-08-14
申请号：US11665868
申请日：2005-10-20
申请人： Sang-June Nam , So-Young Chung , Jeong-Jun Han , Wang-Keun Choi , Chang-Seo Park , Yun-Sik Kim , Sang-Woo Cho , Young-Ho Lee , Jin-Wook Kim , Ui-Chan Koh
发明人： Sang-June Nam , So-Young Chung , Jeong-Jun Han , Wang-Keun Choi , Chang-Seo Park , Yun-Sik Kim , Sang-Woo Cho , Young-Ho Lee , Jin-Wook Kim , Ui-Chan Koh
IPC分类号： A61K8/55 , A61K31/685 , A61Q17/04 , A61Q17/00
CPC分类号： A61K31/685
摘要： Disclosed is a composition containing phosphatidylserine as an effective ingredient, and more particularly to a composition containing phosphatidylserine as an effective ingredient for protecting and improving a skin, reinforcing a skin barrier function, suppressing and alleviating an inflammatory response, treating and improving an atopic skin, activating PPAR-a promoting a differentiation of the skin, protecting the skin and preventing and improving skin aging and wrinkle. Accordingly, it is possible to protect and improve the skin from the injury due to the ultraviolet or the external stimulating material such as chemical material and to reinforce and strengthen the skin barrier function using the composition, thereby improving a general skin state.
摘要翻译： 公开了含有磷脂酰丝氨酸作为有效成分的组合物，更具体地，涉及含有磷脂酰丝氨酸作为保护和改善皮肤，增强皮肤屏障功能，抑制和减轻炎症反应，治疗和改善特应性皮肤的有效成分的组合物， 激活PPAR-a促进皮肤分化，保护皮肤，预防和改善皮肤老化和皱纹。 因此，可以保护和改善由于紫外线或外部刺激材料如化学材料造成的伤害的皮肤，并且可以使用该组合物增强和增强皮肤屏障功能，从而改善一般的皮肤状态。
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3.发明授权Composition for protection and improvement of skin, or reinforcing skin barrier function comprising phosphatidylserine 有权用于保护和改善皮肤或包含磷脂酰丝氨酸的增强皮肤屏障功能的组合物公开(公告)号：US08022051B2
公开(公告)日：2011-09-20
申请号：US11665868
申请日：2005-10-20
申请人： Sang-June Nam , So-Young Chung , Jeong-Jun Han , Wang-Keun Choi , Chang-Seo Park , Yun-Sik Kim , Sang-Woo Cho , Young-Ho Lee , Jin-Wook Kim , Ui-Chan Koh
发明人： Sang-June Nam , So-Young Chung , Jeong-Jun Han , Wang-Keun Choi , Chang-Seo Park , Yun-Sik Kim , Sang-Woo Cho , Young-Ho Lee , Jin-Wook Kim , Ui-Chan Koh
IPC分类号： A61K31/685 , A61P17/00 , A61P17/16
CPC分类号： A61K31/685
摘要： Disclosed is a composition containing phosphatidylserine as an effective ingredient, and more particularly to a composition containing phosphatidylserine as an effective ingredient for protecting and improving a skin, reinforcing a skin barrier function, suppressing and alleviating an inflammatory response, treating and improving an atopic skin, activating PPAR-a promoting a differentiation of the skin, protecting the skin and preventing and improving skin aging and wrinkle. Accordingly, it is possible to protect and improve the skin from the injury due to the ultraviolet or the external stimulating material such as chemical material and to reinforce and strengthen the skin barrier function using the composition, thereby improving a general skin state.
摘要翻译： 公开了含有磷脂酰丝氨酸作为有效成分的组合物，更具体地，涉及含有磷脂酰丝氨酸作为保护和改善皮肤，增强皮肤屏障功能，抑制和减轻炎症反应，治疗和改善特应性皮肤的有效成分的组合物， 激活PPAR-a促进皮肤分化，保护皮肤，预防和改善皮肤老化和皱纹。 因此，可以保护和改善由于紫外线或外部刺激材料如化学材料造成的伤害的皮肤，并且可以使用该组合物增强和增强皮肤屏障功能，从而改善一般的皮肤状态。
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4.发明申请ACID TOLERANT LEUCONOSTOC MESENTEROIDES WITH EXCELLENT MANNITOL PRODUCTIVITY AND METHOD FOR PRODUCING A KIMCHI USING THE SAME 审中-公开具有优异的人造丝生产能力的耐酸的紫杉醇麦芽糖和使用它的KIMCHI生产方法公开(公告)号：US20090022850A1
公开(公告)日：2009-01-22
申请号：US12087161
申请日：2005-12-29
申请人： Ji-Young Oh , Si-Young Yang , Min-Soo Kwon , Jiyoung Oh , Jin-Hyuk Lee , Gyeong-Ho Han , Ui-Chan Koh
发明人： Ji-Young Oh , Si-Young Yang , Min-Soo Kwon , Jiyoung Oh , Jin-Hyuk Lee , Gyeong-Ho Han , Ui-Chan Koh
摘要： The present invention relates to acid tolerant Leuconostoc mesenteroides with excellent mannitol productivity and the use thereof. The inventive lactic acid bacteria is useful as a food additive composition and a Kimchi starter. Kimchi prepared with the addition of the inventive lactic acid bacteria is maintained at a suitable ripening degree over an extended period of time than to the prior Kimchis, and has excellent sensory properties, including excellent refreshing taste, weak sour odor and a very soft quality of sour taste.
摘要翻译： 本发明涉及具有优异的甘露醇生产力的耐酸性明串珠菌肠炎菌及其用途。 本发明的乳酸菌可用作食品添加剂组合物和泡菜起子。 通过添加本发明的乳酸菌制备的泡菜在延长的时间段内保持在合适的成熟度上，而不是以前的Kimchis，并且具有优异的感官特性，包括优异的清爽味道，弱酸味和非常柔软的质量 酸味。
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