摘要:
A GPCR142/relaxin3 and GPCR142/INSL5 complexes are described. The complexes are useful as assay reagents for screening for modulators of GPCR142 receptor activity.
摘要:
Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.
摘要:
The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor protein. This method combines and utilizes known methods and cell lines selected for their natural expression of orexin-2 receptors to carry out the methods of the present invention. Exemplary methods of the present invention utilize PFSK-1 cells to produce non-recombinant human orexin-2 receptor protein.
摘要:
An article hanger including a body having at least one clamp. The clamp has first and second jaw members with opposed first and second gripping pads, respectively. The first gripping pad includes a first gripping surface that has a relief structure formed by projections that have a depth between 0.01 mm and 0.5 mm (and most preferably between 0.01 mm and 0.25 mm). The second gripping pad includes a second gripping surface that is substantially smooth. The projections of the relief structure may have pointed ends or planar end surfaces, and may be part of a texture or pattern (e.g., a pattern of cross-hatched grooves) that is imparted to the first gripping surface. The gripping pads of the jaw members are integrally formed therewith preferably with the same thermoplastic material or other suitable material. In the preferred embodiment, the hanger body is integrally formed together with at least one jaw member of the clamp(s) and its gripping pad.
摘要:
The apparatus for creating and editing a nuclear reactor core template includes a graphical user interface and a processor controlling the graphical user interface to allow a user to selectively populate a loading map with fuel bundles residing in at least one fuel pool.
摘要:
A top indicating means for a hanger having a metal hook includes two mounting portions and an indicator. Each of the mounting portions includes a base defining a curved channel, engagement structure to couple the mounting portions together, and preferably alignment structure for aligning the mounting portions relative to each other. Each of the mounting portions also includes an indicator support having a web and locking structure for locking the indicator on the web. In use, the mounting portions are positioned on either side of the upper portion of the metal hook of the hanger and locked together. The indicator is then pushed over the top of the adjacent web portions and locked thereon.
摘要:
A hanger according to the invention includes a cross member with a centrally located hook. A web is formed between the hook and the cross member and is adapted to receive a conventional indicator. The web includes a rib, followed by a valley, followed by a ramp, followed by a plateau. According to the invention, the rib is beveled at the one end and a notch is provided in the web adjacent the beveled end of the rib, the notch extending from the rib to the ramp or to the plateau. The indicator is easily removed from the rib by pressing it into the notch, then sliding it off the web.